Reviewer #3 (Public Review): Regional response to light illuminance across the human hypothalamus DOI Open Access

Published: July 8, 2024

Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, subcortical circuitry underlying stimulating impact light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess variations illuminance regional activity hypothalamus while healthy young adults (N=26; 16 women; 24.3 ± 2.9y) were completing two auditory cognitive tasks. find that, during both executive emotional tasks, higher triggered an increase over posterior part hypothalamus, which includes tuberomamillary nucleus lateral hypothalamus. In contrast, increasing evoked a decrease anterior ventral parts encompassing notably suprachiasmatic another tuberomammillary nucleus. Critically, performance task was improved under negatively correlated with area. These findings reveal distinct local dynamics different regions that underlie

Language: Английский

A Study of the Emotional Impact of Interior Lighting Color in Rural Bed and Breakfast Space Design DOI Creative Commons
Yangyang Wei,

Yuan Zhang,

Yihan Wang

et al.

Buildings, Journal Year: 2023, Volume and Issue: 13(10), P. 2537 - 2537

Published: Oct. 7, 2023

In architectural spaces, the ambiance created by lighting plays a significant role in influencing people’s emotions, often relying on use of color and light. However, previous research has primarily focused urban with relatively less attention given to rural environments, especially interior spaces accommodation. The objective this study is investigate impact colored within accommodation interiors emotions visual perceptions. Additionally, aims establish an emotional dimension model map experimental results onto eight basic utilizing PAD for quantitative analysis. To achieve goal, researchers recruited 90 participants divided them into six groups, each experiencing different combinations indoor scenes varying colors. Participants evaluated their indicate that combination cool warm white light significantly influences arousal level but lower pleasure levels, dominance relaxation levels. comparing experienced after exposure followed light, elicited more positive emotions. Furthermore, following diminished sense warmth while yellow–blue enhanced comfort blue–red increased attraction. Overall, effect improving negative was weak. Conversely, blue–yellow or green–yellow had enhancing perceptions reducing participants’ anxiety. This provides valuable insights references designing design, potential enhance spatial experience accommodations.

Language: Английский

Citations

8

GABAergic Retinal Ganglion Cells Projecting to the Superior Colliculus Mediate the Looming-Evoked Flight Response DOI
Man Yuan,

Gao Tan,

Danrui Cai

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Language: Английский

Citations

2

Beyond Lux: Methods for Species and Photoreceptor-Specific Quantification of Ambient Light for Mammals DOI Creative Commons
Richard J. McDowell, Altuğ Didikoğlu, Tom Woelders

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 27, 2023

Abstract Background Light is a key environmental regulator of physiology and behaviour. Mistimed or insufficient light disrupts circadian rhythms associated with impaired health well-being across mammals. Appropriate lighting therefore crucial for indoor housed The most commonly used measurement lux. However, this employs spectral weighting function based on human perceived brightness not suitable ‘non-visual’ effects use species. In humans, photoreceptor-specific (α-opic) metrology system has been proposed as more appropriate way measuring light. Results Here we establish technology to allow α-opic approach be readily extended any mammalian species, accounting differences in photoreceptor types, photopigment sensitivities, eye anatomy. Since sensitivity can hard derive novel animals photoreceptors, developed high-throughput, easy-to-use, method sensitivities recombinantly expressed melanopsins it the melanopsin from 12 non-human We further address need simple strategies species-specific measures by developing an accessible online toolbox calculating these units validating open hardware, low-cost, multichannel sensor ‘point click’ measurement. finally demonstrate that measurements are superior photopic lux predictors physiological responses mice ecologically relevant comparisons photosensitivity between Conclusion Our study demonstrates accurately using existing unit holds promise improvements welfare animals, scientific research reproducibility, agricultural productivity, energy usage.

Language: Английский

Citations

5

Attentional Correlates of Colored Lights: Considerations for Cognitive Testing DOI

V Divya Vani,

Pooja Ojha,

Mahesh Arjundan Gadhvi

et al.

Neuroscience, Journal Year: 2024, Volume and Issue: 543, P. 83 - 89

Published: Feb. 23, 2024

Language: Английский

Citations

1

Regional response to light illuminance across the human hypothalamus DOI
Islay Campbell, Roya Sharifpour, Jose Fermin Balda Aizpurua

et al.

eLife, Journal Year: 2024, Volume and Issue: 13

Published: April 23, 2024

Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, subcortical circuitry underlying stimulating impact light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess variations illuminance regional activity hypothalamus while healthy young adults (N=26; 16 women; 24.3±2.9 y) were completing two auditory cognitive tasks. find that, during both executive emotional tasks, higher triggered an increase over posterior part hypothalamus, which includes tuberomamillary nucleus lateral hypothalamus. In contrast, increasing evoked a decrease anterior ventral parts encompassing notably suprachiasmatic another tuberomammillary nucleus. Critically, performance task was improved under negatively correlated with area. These findings reveal distinct local dynamics different regions that underlie

Language: Английский

Citations

1

Exposure to light supresses the activity of the medial and superior amygdala during emotional processing DOI
Islay Campbell, Jose Fermin Balda Aizpurua, Roya Sharifpour

et al.

Published: April 28, 2024

Abstract Background Light can influence several non-image-forming biological effects including the modulation of mood and emotional processing through neural circuitry that remains to be fully established. Rodent data showed nuclei amygdala, known important regulation processing, receive direct inputs from retina mediate part affective impact light. Here, we wanted assess whether these animal findings translate human beings. We determine dynamics light exposure on activity varied across its volume, during stimulation. Methods used 7 Tesla functional magnetic resonance imaging variations in illuminance regional amygdala healthy young adults (N = 29; 18 women; 24 ± 3.1y) an auditory task. Results find subregions medial nucleus receives retinal projection, a marked linear reduction with increasing when emotionally charged stimuli. Conclusion speculate it is affects state individuals. These shed more mechanisms underlie brain may contribute benefits therapy treatment disorders.

Language: Английский

Citations

1

Beyond Lux: methods for species and photoreceptor-specific quantification of ambient light for mammals DOI Creative Commons
Richard J. McDowell, Altuğ Didikoğlu, Tom Woelders

et al.

BMC Biology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 14, 2024

Abstract Background Light is a key environmental regulator of physiology and behaviour. Mistimed or insufficient light disrupts circadian rhythms associated with impaired health well-being across mammals. Appropriate lighting therefore crucial for indoor housed commonly measured in lux. However, this employs spectral weighting function human luminance not suitable ‘non-visual’ effects use species. In humans, photoreceptor-specific (α-opic) metrology system has been proposed as more appropriate way measuring light. Results Here we establish technology to allow α-opic measurement approach be readily extended mammalian species, accounting differences photoreceptor types, photopigment sensitivities, eye anatomy. We develop high-throughput method derive sensitivities recombinantly expressed opsins it the sensitivity melanopsin from 13 non-human further address need simple strategies species-specific measures by developing an accessible online toolbox calculating these units validating open hardware multichannel sensor ‘point click’ measurement. finally demonstrate that measurements are superior photopic lux predictors physiological responses mice ecologically relevant comparisons photosensitivity between Conclusions Our study presents methods existing unit holds promise improvements welfare animals, scientific research reproducibility, agricultural productivity, energy usage.

Language: Английский

Citations

1

A wrist worn Internet-of-Things sensor node for wearable equivalent daylight illuminance monitoring DOI Creative Commons
Alexander J. Casson

Published: May 15, 2023

<p>Light exposure is a vital regulator of physiology and behaviour in humans. However, monitoring light not included current wearable Internet-of-Things (IoT) devices, only recently have international standards defined <em>alpha-opic equivalent daylight illuminance</em> measures for how the eye responds to light. This paper reports sensor node that can be incorporated into IoT provide illuminance real-world settings. We present system design, electronic performance testing, accuracy measurements when compared calibrated spectral source. includes consideration directional response sensor, comparison placed on different parts body, demonstration practical use over 7 days. Our device operates 3.5 days between charges, with sampling period 30 s. It has 10 channels measurement, range 415-910 nm, balancing cost considerations. Measured alpha-opic Equivalent Daylight Illuminance results 13 devices show mean absolute error less than 0.07 log lx, minimum correlation 0.99. These findings demonstrate accurate sensing feasible, including at wrist worn locations. an experimental platform future investigations based lighting control.</p>

Language: Английский

Citations

2

Regional response to light illuminance across the human hypothalamus DOI
Islay Campbell, Roya Sharifpour, Jose Fermin Balda Aizpurua

et al.

Published: April 23, 2024

Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, subcortical circuitry underlying stimulating impact light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess variations illuminance regional activity hypothalamus while healthy young adults (N=26; 16 women; 24.3 ± 2.9y) were completing two auditory cognitive tasks. find that, during both executive emotional tasks, higher triggered an increase over posterior part hypothalamus, which includes tuberomamillary nucleus lateral hypothalamus. In contrast, increasing evoked a decrease anterior ventral parts encompassing notably suprachiasmatic another tuberomammillary nucleus. Critically, performance task was improved under negatively correlated with area. These findings reveal distinct local dynamics different regions that underlie They may suggest acts orexin histamine system affect quality wakefulness.

Language: Английский

Citations

0

Exploring Methodological Considerations: A Literature Review on How Lighting Affects the Sleep and Cognition in Healthy Older Adults DOI Creative Commons

Mahya Fani,

Nina Sharp

Journal of Daylighting, Journal Year: 2024, Volume and Issue: 11(1), P. 97 - 118

Published: June 6, 2024

The impacts of lighting conditions on human circadian rhythms, sleep quality, and cognitive performance have been extensively investigated in the past two decades; however, these studies yielded inconclusive variable outcomes. For older adults who are at a higher risk developing serious physiological mental illnesses, such as Alzheimer’s or dementia, light therapy has emerged low-risk intervention to improve quality function. Nevertheless, optimal methodology for evaluating efficacy remains unclear. This review conducted according Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines critically analyzes methodologies previous lighting's impact healthy adults, focusing how approaches affect findings. is structured into six domains: study setting type, participant characteristics, conditions, design, evaluation methods, methods. Diverse designs, population characteristics influenced Bright light, applied from early morning evening, shown enhance functions, notably working memory concentration. It also benefits dawn simulation throughout day, which regulates rhythms improves although ideal timing yet be determined. Intense short-wavelength lights strong placebo can counteract positive effects, using bright evening may impair indirectly worsen adults. Further real-world experimental this demographic, meticulous combination objective subjective comprehensive reporting interventions crucial identifying design approach population.

Language: Английский

Citations

0