The Causal Relationship between the Morning Chronotype and the Gut Microbiota: A Bidirectional Two-Sample Mendelian Randomization Study

Nutrients, Journal Year: 2023, Volume and Issue: 16(1), P. 46 - 46

Published: Dec. 22, 2023

Background: Numerous observational studies have documented an association between the circadian rhythm and composition of gut microbiota. However, bidirectional causal effect morning chronotype on microbiota is unknown. Methods: A two-sample Mendelian randomization study was performed, using summary statistics from European Consortium those largest available genome-wide meta-analysis, conducted by MiBioGen consortium. The inverse variance-weighted (IVW), weighted mode, median, MR-Egger regression, simple mode methods were used to examine reverse analysis microbiota, which identified as causally linked in initial analysis. Cochran’s Q employed assess heterogeneity instrumental variables. Results: Inverse estimates suggested that had a protective Family Bacteroidaceae (β = −0.072; 95% CI: −0.143, −0.001; p 0.047), Genus Parabacteroides −0.112; −0.184, −0.039; 0.002), Bacteroides 0.047). In addition, (Family (OR 0.925; 0.857, 0.999; 0.915; 0.858, 0.975; 0.007), 0.047)) demonstrated positive effects chronotype. No significant variables, or horizontal pleiotropy, found. Conclusion: This found Bacteroidaceae, Parabacteroides, associated with Further randomized controlled trials are needed clarify chronotype, well their specific mechanisms.

Language: Английский

Unraveling the interplay between chronobiology, circadian rhythm, and gut microbiome dynamics in human health

InterConf, Journal Year: 2024, Volume and Issue: 43(193), P. 291 - 303

Published: March 20, 2024

Background: This study investigates the intricate interplay between disrupted circadian rhythms, sleep variations, and gut microbiota dynamics, recognizing their bidirectional influences on human health. The relationships are explored through brain-gut-microbiota axis, emphasizing importance of maintaining a harmonious balance for overall well-being. Methods: A selection criteria was determined after thorough literature review across search engines databases. SANRA guidelines were followed to draft manuscript. Objectives: To elicit patterns, chronobiology, rhythm influence composition functionality microbiome in participants. Results: Disruptions rhythms impact composition, leading dysbiosis pathological mechanisms. Reciprocally, variations duration quality diversity function microbiome. Identified microbial patterns associated with different phases reveal nuanced connections, highlighting broader implications disruption

Language: Английский

Levilactobacillus brevis SG031 modulates mood-related behaviors and attenuates stress-related sleep disturbance and autonomic dysfunction via gut microbiota modulation in Wistar–Kyoto rats

Life Sciences, Journal Year: 2024, Volume and Issue: 351, P. 122804 - 122804

Published: June 7, 2024

Language: Английский