Infection-Free and Enhanced Wound Healing Potential of Alginate Gels Incorporating Silver and Tannylated Calcium Peroxide Nanoparticles

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5196 - 5196

Published: May 10, 2024

The treatment of chronic wounds involves precise requirements and complex challenges, as the healing process cannot go beyond inflammatory phase, therefore increasing time implying a higher risk opportunistic infection. Following better understanding process, oxygen supply has been validated therapeutic approach to improve speed up wound healing. Moreover, local implications antimicrobial agents (such silver-based nano-compounds) significantly support normal by combating bacterial contamination colonization. In this study, silver (S) tannylated calcium peroxide (CaO2@TA) nanoparticles were obtained adapted microfluidic precipitation synthesis methods, respectively. After complementary physicochemical evaluation, both types loaded in (Alg) alginate-based gels that further evaluated possible dressings for composites showed porous structure uniform distribution through polymeric matrix (evidenced spectrophotometric analysis electron microscopy studies), together with good swelling capacity. as-proposed gel exhibited constant suitable concentration released oxygen, shown eight hours (UV-Vis investigation). biofilm modulation data indicated synergistic effect between nanoparticles, prominent inhibitory action against Gram-positive after 48 h. Beneficial effects human keratinocytes cultured contact materials demonstrated performed tests, such MTT, LDH, NO.

Language: Английский

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An interdisciplinary approach to assessing the toxicity reduction of cerium oxide nanoparticles coated with polyethylene glycol and polyvinylpyrrolidone polymers: An in vitro study

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: unknown, P. 106022 - 106022

Published: Feb. 1, 2025

Language: Английский

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Eco-friendly green synthesis of silver nanoparticles utilizing olive oil waste by-product and their incorporation into a chitosan-aloe vera gel composite for enhanced wound healing in acid burn injuries

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 165, P. 112587 - 112587

Published: May 21, 2024

Language: Английский

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Hybrid silver nanoparticles: Modes of synthesis and various biomedical applications

Electron, Journal Year: 2024, Volume and Issue: 2(2)

Published: May 1, 2024

Abstract In the present day, there is a growing trend of employing new strategies to synthesize hybrid nanoparticles, which involve combining various functionalities into single nanocomposite system. These modern methods differ significantly from traditional classical approaches and have emerged at forefront materials science. The fabrication nanomaterials presents an unparalleled opportunity for applications in wide range areas, including therapy diagnosis. focus this review article shed light on different modalities providing concise description silver exploring modes synthesis classification highlighting their advantages. Additionally, we discussed core‐shell nanoparticles types core shell combinations based material category, such as dielectric, metal, or semiconductor. two primary classes were also reviewed. Furthermore, but emphasize silica suitable candidate hybridization alongside metal nanoparticles. This choice due its hydrophilic surface qualities high charge, provide desired repulsive forces minimize aggregation between liquid solution. Silica encapsulation provides chemical inertness, robustness adaptability nanoparticle. Therefore, among all used coat nanoparticles; highly approved.

Language: Английский

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Functionalization of Polyvinylpyrrolidone Films by Grafting Maleic Acid from PVP Gels for Loading Studies of Naringin and Silver Nanoparticles as Potential Wound Dressings

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 147 - 147

Published: Feb. 19, 2025

Wound healing is a complex process involving stages such as hemostasis, inflammation, proliferation, and remodeling. In this context, polymers are useful materials for wound treatment. This research used the Casting method to prepare films from 2% polyvinylpyrrolidone (PVP) gels. Subsequently, PVP were grafted with maleic acid (MA) (PVP-g-PAM) load naringin (NA) silver nanoparticles (AgNPs) in order obtain material pH responsiveness antibacterial properties. The modified PVP-g-PAM prepared using gamma-ray irradiation through pre-irradiation oxidative at dose rate of 13.7 kGy h-1, doses ranging 10 25 kGy, reaction times 50 80 min bath water, all samples °C, fixed monomer concentration 15% (w/v) MA THF. conditions that yielded highest percentage grafting 20 60 min. NA was loaded 5%. Data release showed follow Korsmeyer-Peppas kinetic model. Synthesis AgNPs performed by γ-ray irradiation-reduction (10 30 kGy), stabilizer. vitro effectiveness against E. coli S. aureus. Films characterized FTIR-ATR, TGA, DSC, mechanical properties, swelling index, contact angle. Further studies must be implemented; however, results up now suggest can potential dressing.

Language: Английский

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Characterization of the fate of primary and re-precipitated silver nanoparticles in lake water model systems

Frontiers in Environmental Chemistry, Journal Year: 2025, Volume and Issue: 6

Published: Feb. 27, 2025

The increasing use of silver nanoparticles (nAg) in products and associated releases to the environment necessitates a thorough understanding environmental fate transformations these potentially toxic nanomaterials inform risk assessments. Herein, physical chemical nAg natural lake water samples were investigated. Lake systems containing filtered unfiltered (FLW UFLW) spiked with 80 nm polyvinylpyrrolidone-coated (nAg pristine ) at 6 μg/L maintained under quiescent or mixed conditions dark for up 44 days. Aliquots withdrawn from column contained smaller re-precipitated (r-nAg, diameter ∼26 nm) formed by precipitation Ag + released oxidative dissolution . number concentrations r-nAg comparable. In FLW, agglomerates partially dissolved their settling accelerated after 14 days, but no occurred systems. UFLW, heteroagglomerates colloids induced sedimentation both A fraction larger (>40 primary n-Ag (comprised its itself) persistent several weeks. Under conditions, more p-nAg remained suspended FLW (15.7%, relative dosed) than UFLW (5.9%), whereas persisted (2.6%) (0.6%). Thus, size distributions fractions persisting can change significantly depending on chemistry mixing conditions.

Language: Английский

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Citric acid-optimized green synthesis of AgNPs: A sustainable approach for effective antimicrobial agents

Biocatalysis and Biotransformation, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 22, 2025

Language: Английский

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Microbial Routes for Nanoparticle Synthesis

Published: Jan. 1, 2025

Language: Английский

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Synergistic Cancer Therapies Enhanced by Nanoparticles: Advancing Nanomedicine Through Multimodal Strategies

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(6), P. 682 - 682

Published: May 22, 2025

Cancer remains a formidable global health challenge due to its complex pathophysiology and resistance conventional treatments. In recent years, the convergence of nanotechnology oncology has paved way for innovative therapeutic platforms that address limitations traditional modalities. This review examines how nanoparticle (NP)-based strategies enhance efficacy chemotherapy, radiotherapy, phototherapy, immunotherapy, gene therapy by enabling targeted delivery, controlled drug release, tumor-specific accumulation via enhanced permeability retention (EPR) effect. We discuss design functionalization various organic, inorganic, hybrid NPs, highlighting their roles in improving pharmacokinetics, overcoming multidrug resistance, modulating tumor microenvironment. Particular emphasis is placed on dual multimodal therapies, such as chemo-phototherapy, chemo-immunotherapy, gene-radiotherapy, leverage carriers amplify synergistic effects, minimize systemic toxicity, improve clinical outcomes. also explore cutting-edge advances editing personalized nanomedicine, well emerging biological barriers immunosuppressive mechanisms niche. Despite undeniable promise nanoparticle-based cancer challenges related scalable manufacturing, regulatory oversight, long-term biocompatibility must be overcome before they can fully enter practice. By synthesizing findings identifying key opportunities innovation, this provides insight into nanoscale are propelling next generation precision oncology.

Language: Английский

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Anti-Methicillin-Resistant Staphylococcus aureus Efficacy of Layer-by-Layer Silver Nanoparticle/Polyacrylic Acid-Coated Titanium Using an In-House Dip Coater

Polymers, Journal Year: 2025, Volume and Issue: 17(3), P. 333 - 333

Published: Jan. 25, 2025

The emergence of methicillin-resistant Staphylococcus aureus (MRSA) is still posing a global challenge in healthcare settings. This bacterial strain cause severe periprosthetic infection, thereby impairing the success implant insertion. To address this issue, surface modification required. Herein, we developed novel multilayered silver nanoparticle/polyacrylic acid-coated Ti plate (AgNPs/PAA/Ti) using an in-house dip coater. AgNPs were synthesized and characterized. dip-coating process was optimized based on dipping rate, evaporation time, coating cycle number. Uniform reproducible coatings achieved surfaces, with consistency verified through SEM analysis. average size approximately 36.50 ± 0.80 nm PDI 0.443 0.025, zeta potential measured at around –23.3 2.0 mV. maximum thickness 83.5 1.3 µm observed 15 cycles coating. Moreover, our AgNPs/PAA/Ti showed both antimicrobial biofilm-resistant performance, while also exhibiting enhanced biocompatibility cultured MG63 osteosarcoma cells, maintaining cell viability greater than 70%. We envisage that material holds significant promise as candidate for medical devices, offering protection against MRSA-associated infection insertion sites low vascularity future.

Language: Английский

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