Assessment of the effect of hypothermia after simulated hypoxic ischemic encephalopathy based on blood metabolome DOI Creative Commons

CM El'darov,

Natalia Starodubtseva,

Yulia A. Shevtsova

et al.

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(6)

Published: Dec. 1, 2024

Hypoxic ischemic encephalopathy (HIE) is a severe neonatal condition causing various neurological disorders and one of the main causes mortality among full-term babies. Therapeutic hypothermia (TH), i.e. newborn’s body temperature decrease that significantly reduces risk fatality contributes to improvement long-term outcomes in infants with HIE key treatment method for moderate-to-severe HIE. However, timely diagnosis disease severity determination are crucial this be used, has number limitations requirements. Assessment mechanism underlying effects TH search major metabolic pathways potential targets therapy relevant. The study aimed assess metabolome dried blood spots by HPLC-MS, since it least invasive patients test markers most active likely mediate its positive effects. As result, alterations class phosphoglycerolipids were found, which suggests an important role endocannabinoid metabolism protection against Furthermore, ubiquinone, certain fatty acids, bile acids altered. targeted quantitative studies these metabolites will make possible optimize based on identified.

Language: Английский

Research on the Innovation of Ideological and Political Education Methods for College Students under the Background of “Internet+” DOI Open Access
Taohong Zhang

Applied Mathematics and Nonlinear Sciences, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract The network data in the era of “Internet +” brings a new growth space for ideological and political education, combination big education promotes practice colleges universities to go deeper deeper. This paper establishes an innovative application model college students context analysis early warning methods “Internet+” era. After normalizing learning behavior online platform, XGBOOST algorithm is used realize prediction accurate educational intervention carried out according results. It found that performance this much better than other comparative models, which supports education. Educational shows students’ class (1) improved significantly after implementation precise policy model, number with low motivation decreased from 12 2. Moreover, grade course (86.52 points) was higher (2) under traditional (78.05 points), indicating has achieved significant method proposed study can improve path promoting function data, fully utilize universities, adapt development times, constantly deliver talents country.

Language: Английский

Citations

0

Assessment of the effect of hypothermia after simulated hypoxic ischemic encephalopathy based on blood metabolome DOI Creative Commons

CM El'darov,

Natalia Starodubtseva,

Yulia A. Shevtsova

et al.

Bulletin of Russian State Medical University, Journal Year: 2024, Volume and Issue: 2024(6)

Published: Dec. 1, 2024

Hypoxic ischemic encephalopathy (HIE) is a severe neonatal condition causing various neurological disorders and one of the main causes mortality among full-term babies. Therapeutic hypothermia (TH), i.e. newborn’s body temperature decrease that significantly reduces risk fatality contributes to improvement long-term outcomes in infants with HIE key treatment method for moderate-to-severe HIE. However, timely diagnosis disease severity determination are crucial this be used, has number limitations requirements. Assessment mechanism underlying effects TH search major metabolic pathways potential targets therapy relevant. The study aimed assess metabolome dried blood spots by HPLC-MS, since it least invasive patients test markers most active likely mediate its positive effects. As result, alterations class phosphoglycerolipids were found, which suggests an important role endocannabinoid metabolism protection against Furthermore, ubiquinone, certain fatty acids, bile acids altered. targeted quantitative studies these metabolites will make possible optimize based on identified.

Language: Английский

Citations

0