Modelling of Flavanoid Derivatives from Leucaena leucocephala as Anti-UV DOI Open Access
Rokiy Alfanaar,

Tety Wahyuningsih Manurung,

Mokhamat Ariefin

et al.

Stannum Jurnal Sains dan Terapan Kimia, Journal Year: 2024, Volume and Issue: 6(1), P. 21 - 27

Published: May 1, 2024

While UV light has benefits for life, excessive exposure to also negative effects on humans. Examples of the include cancer. Therefore, exploration materials that can be used as anti-UV continues grow. One them is extract from Leucaena leucocephala leaves. To study potential a compound anti-UV, one method use molecular modeling approach using semi-empirical method. Based this, 8 flavone-derived compounds contained in L. leaf were modeled with PM3 method, and electronic-transition was calculated ZINDO/S. The geometry optimization results showed bond length between carbon atoms flavonoid tururnans did not change significantly difference functional groups. However, there significant dihedral angle due repulsion electronic transition calculation all derivatives 1-8 are active A, B, C regions. So it said flavones have anti-UV. In addition, energy level HOMO-LUMO calculated. Flavonoid 1 smallest Eg while largest

Language: Английский

A Survey of UV Filters Used in Sunscreen Cosmetics DOI Creative Commons

Alicja Pniewska,

Urszula Kalinowska‐Lis

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(8), P. 3302 - 3302

Published: April 14, 2024

The aim of this study was to determine the types UV filters used in adult and children’s sunscreen products sold Poland (part EU market) their frequency use. INCI compositions were collected analyzed for presence filters. included 150 randomly selected preparations adults (from 71 brands) 50 children 33 brands). survey concerned listed Annex VI Regulation (EC) No 1223/2009 European Parliament Council 30 November 2009 on cosmetic products. most frequently child sunscreens triazine derivatives: bis-ethylhexyloxyphenol methoxyphenyl (60.0%) ethylhexyl triazone (52.0%), salicylate (46.0%), a derivative salicylic acid. common butyl methoxydibenzoylmethane (56.0%), dibenzoylmethane derivative, followed by acid (54.7%) derivatives (50.0%). Physical filters, including nano non-nano forms, more popular children, i.e., 50.0% (TiO2) 22.0% (ZnO), than adults: 21.3% 6.7% (ZnO). For both many contained four or five per preparation; however, often two To summarize, following dominate photoprotectors children: methoxydibenzoylmethane, triazine, triazone, salicylate, diethylamino hydroxybenzoyl hexyl benzoate.

Language: Английский

Citations

20

Stability and Properties of Ultraviolet Filter Avobenzone under Its Diketo/Enol Tautomerization Induced by Molecular Encapsulation with β-Cyclodextrin DOI Creative Commons
Chihiro Kuroda, Tomohiro Tsuchida,

Chihiro Tsunoda

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Inclusion complexation of the sunscreen ingredient avobenzone (AVB) with β-cyclodextrin (β-CD) was investigated to improve its aqueous solubility and photostability; another ultraviolet (UV) filter, oxybenzone (OXB), phytochemical antioxidant curcumin (CUR) served as a comparison. In this study, 1-octanol/water partition coefficients, acid dissociation constants, phase-solubility diagrams β-CD, ultraviolet–visible (UV–vis) spectral changes induced by UVA1 (365 nm) irradiation were evaluated. β-CD at concentrations 50–100 times that AVB most effectively protected photostability AVB. Additionally, an UVA1-insensitive species diketo tautomer, which has UVC-absorbing band potential cause photodegradation, stored in inclusion complex. Acetonitrile–water mixtures various volume ratios screened mimic internal cavity for tautomeric using nuclear magnetic resonance (NMR) integrals components. The results indicated provides hydrophobic environment similar 40–50% acetonitrile solution enhances However, excess hyperchromic effect on tautomer. Aggregation AVB/β-CD complexes ≥2 mM UVC absorption. To avoid molar ratio is recommended optimal composition. This study newly exhibited mitigates reactivity toward inducing tautomer form within cavity.

Language: Английский

Citations

1

The Potential of Natural Compounds in UV Protection Products DOI Creative Commons
Jovana Milutinov, Nebojša Pavlović, Dejan Ćirin

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5409 - 5409

Published: Nov. 16, 2024

Overexposure to ultraviolet radiation mainly leads skin disorders (erythema, burns, immunosuppression), aging, and cancer as the most serious side effect. It has been widely accepted that using sunscreen products is an important way protect against harmful effects of UV rays. Although commercial sunscreens have constantly changed improved over time, there are emerging concerns about safety conventional, organic, filters due adverse on humans (such photoallergic dermatitis, contact sensitivity, endocrine-disrupting effects, etc.) well accumulation in environment aquatic organisms. This why natural compounds increasingly being investigated used cosmetic pharmaceutical sunscreens. Some these available, non-toxic, safer for use, considerable protective properties less effects. Plant-based such flavonoids can absorb UVA UVB rays possess antioxidant, anticarcinogenic, anti-inflammatory contribute photoprotection. Apart from flavonoids, other certain vegetable oils, carotenoids, stilbenes, ferulic acid also UV-absorbing properties. vitamins might be beneficial protection their antioxidant activity. Therefore, aim this research was gain insight into potential replace or reduce amount conventional filters, based recent research.

Language: Английский

Citations

7

Melanin for Photoprotection and Hair Coloration in the Emerging Era of Nanocosmetics DOI Open Access
Arianna Menichetti, Dario Mordini,

Silvia Vicenzi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5862 - 5862

Published: May 28, 2024

Nanotechnology is revolutionizing fields of high social and economic impact. such as human health preservation, energy conversion storage, environmental decontamination, art restoration. However, the possible global-scale application nanomaterials raising increasing concerns, mostly related to toxicity materials at nanoscale. The possibility using in cosmetics, hence products aimed be applied directly body, even just externally, strongly debated. Preoccupation arises especially from consideration that are synthetic origin, often seen "artificial" their effects unpredictable. Melanin, this framework, a unique material since nature it plays important roles specific cosmetics cover, photoprotection hair skin coloration. Moreover, melanin present form nanoparticles, clearly observable ink some animals, like cuttlefish. artificial nanoparticles share same biocompatibility natural ones chemical photochemical properties. Melanin nanocosmetic agent, but its actual still under development, also because regulatory issues. Here, we critically discuss most recent examples biomimetic highlight requirements future steps would improve melanin-based view applications everyday market.

Language: Английский

Citations

5

Computed libraries of avobenzone derivatives with sulfur groups as enhanced UVA filters DOI

D. K. Sahoo,

Smriti Moi,

Konkallu Hanumae Gowd

et al.

Journal of Molecular Modeling, Journal Year: 2025, Volume and Issue: 31(3)

Published: Feb. 19, 2025

Language: Английский

Citations

0

Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters DOI Creative Commons

Pedro Ivo de Souza Macedo,

Claudinéia Aparecida Sales de Oliveira Pinto, Camila Faustino Hiraishi

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 274 - 274

Published: Feb. 26, 2025

Exposure to ultraviolet (UV) radiation is a major contributor skin injury, including sunburn, photoaging, and augmented risk of cancer, primarily through the generation reactive oxygen species (ROS) that induce oxidative stress. Rosmarinic acid (RA), natural phenolic compound with antioxidant several other biological properties, has shown promise in mitigating such damage when incorporated into sunscreens. We evaluated RA's possible interactions potential enhance efficacy three worldwide known UVB filters-ethylhexyl methoxycinnamate (EHMC), octocrylene (OCT), ethylhexyl salicylate (EHS). The performance sunscreens without RA (0.1% w/w) was analyzed vitro vivo photoprotective assessments. HPLC-TBARS-EVSC (high-performance liquid chromatography-thiobarbituric substances-ex stratum corneum) protocol, which quantified stress reduction human corneum, also used. assays showed had distinct levels filters. When associated EHMC, exclusively acted range (SPF-enhancing effect). Remarkably, for EHS, contributed higher profile total UV spectrum. OCT-RA sample reached highest critical wavelength value parallelly OCT, boosting SPF by more than 157% comparison OCT. However, its not affected addition, being comparable EHS-RA. Furthermore, protocol highlighted ability reduce lipid peroxidation, exhibiting most notable protective effect. These findings underscore as multifunctional additive sunscreen systems, enhancing both photoprotection mitigation.

Language: Английский

Citations

0

Potential of Natural-Based Sun Protection Factor (SPF): A Systematic Review of Curcumin as Sunscreen DOI Creative Commons

Ayunda Myela Shabrina,

Raden Siti Salma Azzahra,

Ivana Nathania Permata

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(1), P. 10 - 10

Published: Jan. 15, 2025

Exposure to ultraviolet (UV) radiation from the sun significantly damages skin, leading premature aging, hyperpigmentation, and oxidative stress that disrupts skin homeostasis. UV increases production of reactive oxygen species (ROS), accelerating deterioration. Although sunscreens remain primary method for protection, chemical-based formulations are often associated with side effects, such as allergic reactions acne. To address these concerns, inclusion natural ingredients in sunscreen has gained attention. Curcumin, an active compound found turmeric (Curcuma longa) Java xanthorrhiza), is well-known its antioxidant anti-inflammatory properties. This review explores potential curcumin a ingredient enhancing Sun Protection Factor (SPF) products. A systematic literature was conducted, analyzing 200 articles sourced Google Scholar PubMed using keywords “Curcumin”, “Curcuma”, “Antioxidant”, “Anti-Inflammatory”, “Sun Factor”. Studies unrelated protection were excluded. The findings, presented tabular form, indicate Curcuma exhibit significant enhance SPF values due their antioxidant, anti-inflammatory, UV-absorbing Additionally, may aid repair following UV-induced damage. However, specific concentration various remains unknown, further research necessary determine optimal use. Consideration additional excipients also required maximize efficacy. In conclusion, demonstrates considerable promise sustainable effective protecting radiation, offering safer alternative conventional sunscreens.

Language: Английский

Citations

0

Biotransformation of oxybenzone and 3-(4-methylbenzylidene)camphor in Cunninghamella species: potential for environmental clean-up of widely used sunscreen agents DOI

Aleksandra Murzyn,

Justyna Popiół, Agnieszka Gunia‐Krzyżak

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137544 - 137544

Published: Feb. 11, 2025

Language: Английский

Citations

0

Bioremediation of Persistent Organic Pollutant—Oxybenzone with Pleurotus djamor DOI Creative Commons
Agata Kryczyk‐Poprawa, Wojciech Baran, Katarzyna Sułkowska‐Ziaja

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(9), P. 4707 - 4707

Published: April 24, 2025

Oxybenzone, a common sunscreen ingredient, has been widely detected in various environmental matrices, posing significant ecological and health risks. The present study demonstrates, for the first time, capacity of Pleurotus djamor to degrade oxybenzone vitro cultures. After 14 days mycelial incubation, concentrations medium decreased from 25 mg 1.5394 ± 0.095 mg. final amount mycelium after lyophilization was 6.2067 0.2459 Furthermore, addition significantly reduced biomass growth 2.510 0.6230 g 1.4697 0.0465 g. transformation products dry were assessed identified using UPLC-Q-tof based on monoisotopic molecular mass fragmentation spectra. In processes initiated by P. djamor, mainly acylated derivatives formed. Additionally, compounds with thiol amino groups identified. Alterations antioxidant profiles (L-tryptophan, 6-methyl-D,L-tryptophan, p-hydroxybenzoic acid, ergosterol, lovastatin, phenylalanine, ergothioneine) response exposure observed. Our findings reveal changes levels inhibition, underscoring potential toxicological risks associated oxybenzone. observed reduction concentration highlights as an effective environmentally friendly strategy mitigating this pollutant.

Language: Английский

Citations

0

Impact of endocrine disruptors in cosmetics on reproductive function in males and females DOI

Ahmed Lasaneya,

Queen Saikia,

Sagarika Dutta

et al.

Journal of Environmental Science and Health Part C, Journal Year: 2025, Volume and Issue: 43(2), P. 184 - 207

Published: April 3, 2025

The cosmetic and personal care product (PCP) industries have bloomed in the last ten years. Many new brand names established themselves with various lucrative advertisements, luring youths into their primary customers. chemicals infused daily day-night creams or shampoo conditioners been as Endocrine Disrupting Chemicals (EDC). unseen side of coin has flipped this article an attempt to relate rising infertility issue these products. study aims explore potential adverse effects risk assessment EDCs cosmetics products, which highlights a thorough review indicate whether such parabens, phthalates, UV filters are safe for reproductive physiology. may cause severe negative impacts on systems both males females include problems polycystic ovarian syndrome, hypospadias, cryptorchidism, cancer, endometriosis, poor sperm quality. Despite widespread usage purchase products present world, little research conducted possible health. Consequently, further in-depth needs be performed field better understanding risks caused by EDCs.

Language: Английский

Citations

0