Lipid Nanoparticles Carrying Essential Oils for Multiple Applications as Antimicrobials

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 178 - 178

Published: Jan. 31, 2025

Lipid nanoparticles (LNPs) are versatile delivery systems with high interest because they allow the release of hydrophobic and hydrophilic molecules, such as essential oils (EOs) plant extracts. This review covers published works between 2019 2024 that have reported use EO-based LNPs antimicrobial properties applications in human animal health, well biopesticides. In healthcare field, reports addressed effect encapsulating EOs lipid nanosystems antiviral, antibacterial, antiprotozoal antifungal activities. care, this still needs to be more deeply explored while looking for sustainable alternatives against different types parasites affect health. Overall, antibacterial activities carrying described synthetic antibiotics. field agriculture, studies showed these approaches control phytopathogens other pests food production. There is a growing demand innovative technologies. However, there some challenges overcome order innovations reach market.

Language: Английский

Optimized Hesperidin-Loaded Lipid Nanoparticles with Tea Tree Oil for Enhanced Wound Healing: Formulation, Characterization, and Evaluation

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(3), P. 290 - 290

Published: Feb. 20, 2025

Objectives: This study aimed to develop hesperidin solid lipid nanoparticles (HESP-SLNs) enhance their stability, solubility, and sustained release for wound healing; further enhancement was achieved through prepared nanostructured carriers (HESP-NLCs) using Tea Tree Oil (TTO) explore synergistic efficacy. Methods: A factorial design of 24 trials established evaluate the influence type (X1), conc (%) (X2), surfactant (X3), sonication amplitude (X4) HESP-SLNs on particle size (nm) (Y1), polydispersibility index (Y2), zeta potential (Y3), encapsulation efficiency (Y4). The optimized formula selected utilizing Design Expert® software version 13, which additionally enhanced by preparing TTO-loaded HESP-NLCs. In vitro release, Raman spectroscopy, transmission electron microscopy were carried out both nanoparticles. Cytotoxicity, in vivo wound-healing assessments, skin irritancy tests performed performance TTO-incorporated HESP-NLCs compared HESP-SLNs. Results: demonstrated PS (280 ± 1.35 nm), ZP (−39.4 0.92 mV), PDI (0.239 0.012), EE% (88.2 2.09%). NLCs Q6% (95.14%) vs. (79.69%), SLNs showed superior antimicrobial Both exhibited spherical morphology compatibility between HESP excipients. highest closure percentage, supported histological analysis inflammatory biomarker outcomes. Cytotoxicity evaluation 87% cell viability untreated HSF cells, test confirmed safety NLCs. Conclusions: are promising candidates exhibiting capabilities, making them a therapeutic option cutaneous management.

Language: Английский

Essential Oils in Cosmetics: Antioxidant Properties and Advancements Through Nanoformulations

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100192 - 100192

Published: Feb. 1, 2025

Language: Английский