Assessment of the Diaphragm Thickness Decrease in Critically Ill COVID-19 Patients: Could Computed Tomography Be of Aid Regarding Diaphragm Muscle Mass?

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 17, 2023

Introduction: The diaphragm has a significant clinical value on respiratory performance. There is little literature the use of thorax computed tomography for purpose identifying alterations in thickness critically ill patients diagnosed with COVID-19. present study aims to investigate dynamic changes muscle and its association outcomes. Methods: A single-center retrospective observational was conducted tertiary intensive care unit (ICU). comprised adult severe COVID-19 who were admitted ICU underwent two CT scans. We measured diaphragmatic at level celiac truncus. Results: average reduction found be -0.58 mm right -0.54 left diaphragm. exhibited substantial decrease both sides scans (p=0.02). negative correlation coefficient observed criterion indicating poor prognosis greater than -0.175, whereas it more -0.435. cut-off values indicated high risk prolonged mechanical ventilation an increased mortality. Conclusion: evaluation mechanically ventilated possibility becoming reliable tool predicting modifications.

Language: Английский

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Biopharmaceutical Assessment of Mesh Aerosolised Plasminogen, a Step towards ARDS Treatment

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(6), P. 1618 - 1618

Published: May 30, 2023

Acute respiratory distress syndrome (ARDS) is a severe complication of lung injuries, commonly associated with bacterial, fungal and viral infections, including SARS-CoV-2 infections. ARDS strongly correlated patient mortality its clinical management very complex, no effective treatment presently available. involves failure, fibrin deposition in both airways parenchyma, the development an obstructing hyaline membrane drastically limiting gas exchange. Moreover, hypercoagulation related to deep inflammation, pharmacological action toward aspects expected be beneficial. Plasminogen (PLG) main component fibrinolytic system playing key roles various inflammation regulatory processes. The inhalation PLG has been proposed form off-label administration eyedrop solution, namely, plasminogen-based orphan medicinal product (PLG-OMP), by means jet nebulisation. Being protein, susceptible partial inactivation under aim present work demonstrate efficacy mesh nebulisation PLG-OMP vitro simulation administration, considering enzymatic immunomodulating activities PLG. Biopharmaceutical are also investigated corroborate feasibility inhalation. solution was performed using Aerogen

Language: Английский

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Using cardiovascular risk indices to predict mortality in Covid-19 patients with acute respiratory distress syndrome: a cross sectional study

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: July 15, 2023

Covid-19 patients who require admission to an intensive care unit (ICU) have a higher risk of mortality. Several factors for severe infection been identified, including cardiovascular factors. Therefore, the aim was investigate association between (CV) and major adverse events (MACE) mortality ARDS admitted ICU. A prospective cross-sectional study conducted in university hospital Graz, Austria. were ICU with paO2/fiO2 ratio < 300 included this study. Standard lipid profile measured at determine CV risk. 31 mean age 68 years recruited, stratified using Framingham-, Procam- Charlson Comorbidity Index (CCI) score. total 10 (32.3%) died within 30 days, 8 (25.8%) suffered from MACE during stay. represented by or CCI score not associated rates MACE. Nevertheless, Procam significantly 30- day (13.1 vs. 6.8, p = 0.034). These findings suggest that might be useful estimate prognosis patients.

Language: Английский

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Integrated Transcriptomics and Network Analysis of Potential Mechanisms and Health Effects of Convalescent COVID-19 Patients

Bioinformatics and Biology Insights, Journal Year: 2023, Volume and Issue: 17

Published: Jan. 1, 2023

Coronaviral disease 2019 (COVID-19) is a recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, there are still cases of COVID-19 around the world that can develop into persistent symptoms after discharge. The constellation symptoms, termed long COVID, persists for months and lead to various diseases such as lung inflammation cardiovascular disease, which may considerable financial burden possible risk human health. Moreover, molecular mechanisms underlying post-pandemic remain unclear. In this study, we aimed explore mechanism, association, health risks in convalescent patients. Gene expression data from set was compared with healthy normal individuals order identify differentially expressed genes (DEGs). To determine biological function potential pathway alterations, GO KEGG databases were used analyze DEGs. Disease tissue, organ-specific analyses effects. A total 250 DEGs identified between subjects. alterations revealed cytokine interactions increased through NF-κB1, RELA, JUN, STAT3, SP1. Interestingly, most significant pathways cytokine-cytokine receptor interaction, altered lipid metabolism, atherosclerosis play crucial role COVID-19. addition, also found pneumonitis, dermatitis, autoimmune diseases. Based on our associated variety organs could inflammatory diseases, well atherosclerosis. These findings first step toward fully exploring depth understand relationship post-COVID-19 infection risks. This necessary development appropriate strategies prevention treatment COVID.

Language: Английский

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Factors associated with death due to severe acute respiratory syndrome caused by influenza: Brazilian population study

Journal of Infection and Public Health, Journal Year: 2022, Volume and Issue: 15(12), P. 1388 - 1393

Published: Oct. 26, 2022

Language: Английский

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