AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Nov. 26, 2024

Chemical risk assessment plays a pivotal role in safeguarding public health and environmental safety by evaluating the potential hazards risks associated with chemical exposures. In recent years, convergence of artificial intelligence (AI), machine learning (ML), omics technologies has revolutionized field assessment, offering new insights into toxicity mechanisms, predictive modeling, management strategies. This perspective review explores synergistic AI/ML deciphering clastogen-induced genomic instability for carcinogenic prediction. We provide an overview key findings, challenges, opportunities integrating highlighting successful applications case studies across diverse sectors. From predicting genotoxicity mutagenicity to elucidating molecular pathways underlying carcinogenesis, integrative approaches offer comprehensive framework understanding exposures mitigating risks. Future perspectives advancing cancer prevention through data integration, advanced techniques, translational research, policy implementation are discussed. By implementing capabilities technologies, researchers policymakers can enhance protection, inform regulatory decisions, promote sustainable development healthier future.

Language: Английский

Mushroom-Derived Innovations: Sustainable Biomaterials for Biomedical Engineering

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 23, 2024

This study investigates the transformative potential of mushroom-derived biomaterials within biomedical engineering, presenting them as sustainable and eco-friendly alternatives to conventional materials. By examining distinct characteristics chemical compositions various mushroom species, we highlight their suitability for creating innovative biomaterials. The paper focuses on key components, such polysaccharides, fungal mycelium, chitin/chitosan, demonstrating applications in tissue antimicrobial treatments, drug delivery systems. biodegradability cultivation mushrooms underscore environmental advantages, aligning with global sustainability goals. Through detailed case studies, illustrate successful these medical devices, construction, packaging, showcasing versatility effectiveness. also addresses current challenges proposes future research directions, emphasizing need interdisciplinary collaboration ensure safety, biocompatibility, ethical use mushroom-based Our provides a comprehensive roadmap harnessing materials, paving way significant advancements devices contributing more future. We have demonstrated that are promising frontier material science, revolutionize field contribute environment.

Language: Английский