Effect of Adding Gold Nanoparticles on the Anti-Candidal Activity and Release Profile of Itraconazole from Hydrogels DOI Creative Commons
Radosław Balwierz, Paweł Biernat, Dawid Bursy

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 11125 - 11125

Published: Nov. 29, 2024

Gold nanoparticles have been identified as a promising avenue for the development of drug carriers, particularly in context antimicrobial delivery, where limited solubility represents significant challenge. The ability gold to penetrate biofilms and disrupt fungal cell membranes makes them an effective tool support antifungal therapy, especially against resistant strains. also demonstrate synergistic effects with chemotherapeutics can influence release profile active substances. This study aimed develop topical hydrogel formulation containing itraconazole (ITZ), addition nanoparticles, enhance its therapeutic properties. Due ITZ’s poor water solubility, three types (AuNPs) different sizes were synthesized subsequently coated itraconazole. resulting formulations incorporated into carbopol gels their diffuse through semipermeable was assessed. findings demonstrated that combination elevated diffusion coefficient twice level observed without nanoparticles. Furthermore, combined effect reference Candida albicans strain investigated. growth-inhibitory on this strain, indicating could potentially be employed treatment infections. confirms hydrogels obtained, offering enhanced diffusion.

Language: Английский

Synthesis of Silver Nanoparticles from Pseudophegopteris microstegia (Hook.) Ching and Their Biological Activities against Tomato Gray Mold DOI Creative Commons

Iraj Mushtaq,

Sadaf Kayani, Tijen Demiral

et al.

Journal of Agriculture and Food Research, Journal Year: 2025, Volume and Issue: unknown, P. 101871 - 101871

Published: March 1, 2025

Language: Английский

Citations

0
Synergistic Antifungal Efficacy of Eugenol‐Loaded Nanocapsules Combined With Itraconazole Against Trichophyton mentagrophytes DOI Creative Commons
Javad Malakootikhah, Aghil Sharifzadeh,

Majid Faal Rastegar

et al.

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(3)

Published: May 1, 2025

ABSTRACT Background and Objectives The increasing prevalence of dermatophyte infections the emergence antifungal resistance highlight urgent need for novel treatment approaches. Trichophyton mentagrophytes , a common dermatophyte, often resists standard therapies, necessitating alternative solutions. Eugenol, natural compound with potent properties, has gained attention its synergistic effects conventional agents. However, clinical application is limited by poor bioavailability stability. Nanoencapsulation eugenol offers promising strategy to enhance efficacy address these limitations. This study aims evaluate nanoencapsulated in combination Itraconazole against T. isolates. Methods Eugenol‐loaded nanocapsules were fabricated using nanoprecipitation method subsequently evaluated. activity eugenol, nano‐eugenol Itraconazole—individually combination—was assessed isolates derived from animal human sources, minimum inhibitory concentration (MIC) fungicidal (MFC) determinations. chequerboard assay evaluated effects. Results Scanning electron microscopy (SEM) dynamic light scattering (DLS) analyses showed that have uniform, spherical morphology an average size 150.9 nm moderate polydispersity (polydispersity index [PDI] = 0.531), whereas slight negative zeta potential (−0.1 mV) contributes suspension stability minimizing aggregation. geometric mean MIC was 119.3 µg/mL, significantly lower than (477.4 µg/mL), had lowest at 11 µg/mL. Eugenol demonstrated more effect form, though nanoencapsulation improved bioavailability. Combining synergy 73.3% isolates, reducing Itraconazole's up 1/2 or 1/4. Both forms exhibited effective anti‐dermatophytic activity. Conclusion findings suggest Itraconazole, provides approach potentially dosage risks associated Itraconazole. These results underscore nano‐enhanced plant extracts developing effective, sustainable therapies.

Language: Английский

Citations

0
Pomegranate extract-mediated synthesis of silver nanoparticles: A potential dual-anticancer and antimicrobial agent DOI
Mervat G. Hassan,

Hanaa S. Farouk,

Dina M. Baraka

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112853 - 112853

Published: July 14, 2024

Language: Английский

Citations

3
Naringenin-Capped Silver Nanoparticles Amalgamated Gel for the Treatment of Cutaneous Candidiasis DOI

Chantibabu Katta,

Arbaz Sujat Shaikh,

Nagesh A. Bhale

et al.

AAPS PharmSciTech, Journal Year: 2023, Volume and Issue: 24(5)

Published: May 24, 2023

Language: Английский

Citations

5
Synergistic Antifungal Efficiency of Eco-Friendly Synthesized Zinc Oxide Nanoparticles in Combination with Fluconazole against Drug-Resistant Candidal Strains DOI Open Access
Mohamed Taha Yassin,

Fatimah Olyan Al-Otibi,

Khalid Maniah

et al.

Polish Journal of Environmental Studies, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 5, 2024

The resistance of fungal pathogens to traditional antifungal medications presents a significant public health concern, particularly for immunocompromised patients, leading elevated rates illness and death.This study aimed explore the properties zinc oxide nanoparticles (ZnO NPs) produced using natural approach involving aqueous seed extract Trigonella foenumgracium (Fenugreek).Additionally, assessed combined effectiveness these biologically synthesized ZnO NPs with fluconazole against pathogens.The were observed have hexagonal shape an average diameter 27 nm surface charge -18.3 mV.Notably, exhibited most potent activity Candida tropicalis, relative inhibition zone 18.67±0.56mm.The minimum inhibitory concentration C. tropicalis was determined be 100 µg/mL, while fungicidal found 200 µg/mL.The greatest synergistic effect between glabrata, followed by parapsilosis.In summary, underscores potential combining formulate effective treatment drug-resistant pathogens, thereby enhancing therapeutic efficacy conventional drugs.

Language: Английский

Citations

1
Exploring the potential of eco-friendly silver nanoparticles to inhibit azole-resistant clinical isolates of Candida spp. DOI
Martha V. Roa-Cordero,

María Fernanda Romero Pineda,

Julián Mauricio Guerrero Rodríguez

et al.

Journal of Environmental Science and Health Part A, Journal Year: 2023, Volume and Issue: 58(1), P. 31 - 38

Published: Jan. 2, 2023

The antimicrobial activity and biological efficiency of silver nanoparticles (AgNps) have been widely described can be modeled through stabilizing reducing agents, especially if they exhibit biocidal properties, which enhance bioactivity against pathogens. selective action AgNps remains a major concern. In this regard, the use plant extracts for green synthesis offers advantages because it improves toxicity Nps microorganisms is harmless to normal cells. However, evaluations synthesized using different agents are determined independently, comparisons frequently overlooked. Thus, we investigated compared antifungal cytotoxic effects two ecological from Moringa oleifera aqueous leaf extract (AgNp-M) glucose (AgNp-G) azole-resistant clinical isolates Candida spp. nontumor mammalian Synthesized exhibited an effect on planktonic cells drug-resistant C. albicans tropicalis (MIC 0.21-52.6 µg/mL). was influenced by size. M. allows us obtain that highly nongenotoxic Vero due modifications shape surface. Therefore, these results suggest AgNp-M has potential deserves further investigation biomedical applications.

Language: Английский

Citations

2
Phytomediated synthesis of silver nanoparticles using Lepidium Sativum L. and their antifungal and cytotoxic potential DOI Open Access

El-Haggar Miran A,

El-Hosseiny Lobna S,

Ghazy Nabila M

et al.

Journal of Clinical Microbiology and Biochemical Technology, Journal Year: 2024, Volume and Issue: 10(1), P. 001 - 008

Published: May 13, 2024

Bio-inspired synthesis of nanoparticles has received immense attention recently due to their vast applications in the biomedical field. Herein, a facile process using aqueous extracts Lepidium sativum was used for nanosilver. The phytosynthesized silver showed characteristic surface plasmon absorption peaks at 420 and 440 nm synthesized by seeds leaves, respectively. Moreover, spherical, non-aggregated exhibited particle size 150 zetapotential -15.2 mv countering 111 zeta potential -20 those leave extract correspondingly. Both phytofabricated antifungal effect against Candida albicans with minimum inhibitory concentration 1.75 2.08 ppm promising cytotoxic MCF-7 breast cancer cell line an IC­50 20.1 9.3 nanosilver leaves current work provided simple, environmentally friendly approach green anticandidal action line. However, more investigation is required clarify safety precise mode action.

Language: Английский

Citations

0
Exploration of New Plant-Based Nanoparticles with Potential Antifungal Activity and their Mode of Action DOI
Hardeep Kaur,

Khushbu Wadhwa

Published: Jan. 1, 2024

Language: Английский

Citations

0
Nanopartículas metálicas: una alternativa para combatir la resistencia de especies causantes de la candidiasis DOI Open Access
Luis E. Garcia-Marin, Ernestina Castro‐Longoria

Mundo Nano Revista Interdisciplinaria en Nanociencia y Nanotecnología, Journal Year: 2023, Volume and Issue: 16(31), P. 1e - 14e

Published: May 23, 2023

La candidiasis es provocada por diferentes especies del género Candida, siendo C. albicans la más común en los aislados clínicos a nivel mundial. Esta enfermedad un problema para el sector salud, debido multirresistencia que algunas de Candida presentan antifúngicos tradicionalmente utilizados controlar enfermedad. Tal caso glabrata y recientemente auris, las cuales son resistentes azoles, equinocandinas polienos; lo cual, búsqueda nuevos una prioridad. nanotecnología ofrece nuevas alternativas, como uso nanopartículas (NPs) metálicas, particular, plata cobre han mostrado ser eficientes inhibición albicans. En este trabajo se estudios relevantes evaluado efecto NPs metálicas así resultados prometedores.

Citations

1
Plant Biogenic Nanoparticles as Antifungal Agents DOI

Anand Roy,

Sucheta Sharma,

Joydeb Dey

et al.

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 217 - 242

Published: Nov. 1, 2024

Fungal infections, causing over 1.5 million annual deaths, are a significant global health threat prioritized by the World Health Organization. Plant-based nanoparticle synthesis provides an eco-friendly, rapid, and stable alternative to traditional methods. This chapter reviews synthesis, characterization, antifungal applications, mechanisms, clinical potential of biogenic nanoparticles, which interact with fungal cell walls, disrupt cellular processes, modulate immune responses. Synergistic effects conventional drugs incorporation into new formulations delivery systems enhance their therapeutic potential. However, translation faces challenges related toxicity, pharmacokinetics, regulatory issues. offers valuable insights advancing therapeutics using nanoparticles combat infections globally.

Language: Английский

Citations

0