Effect of Adding Gold Nanoparticles on the Anti-Candidal Activity and Release Profile of Itraconazole from Hydrogels DOI Creative Commons
Radosław Balwierz, Paweł Biernat, Dawid Bursy

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 11125 - 11125

Published: Nov. 29, 2024

Gold nanoparticles have been identified as a promising avenue for the development of drug carriers, particularly in context antimicrobial delivery, where limited solubility represents significant challenge. The ability gold to penetrate biofilms and disrupt fungal cell membranes makes them an effective tool support antifungal therapy, especially against resistant strains. also demonstrate synergistic effects with chemotherapeutics can influence release profile active substances. This study aimed develop topical hydrogel formulation containing itraconazole (ITZ), addition nanoparticles, enhance its therapeutic properties. Due ITZ’s poor water solubility, three types (AuNPs) different sizes were synthesized subsequently coated itraconazole. resulting formulations incorporated into carbopol gels their diffuse through semipermeable was assessed. findings demonstrated that combination elevated diffusion coefficient twice level observed without nanoparticles. Furthermore, combined effect reference Candida albicans strain investigated. growth-inhibitory on this strain, indicating could potentially be employed treatment infections. confirms hydrogels obtained, offering enhanced diffusion.

Language: Английский

Effect of Adding Gold Nanoparticles on the Anti-Candidal Activity and Release Profile of Itraconazole from Hydrogels DOI Creative Commons
Radosław Balwierz, Paweł Biernat, Dawid Bursy

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(23), P. 11125 - 11125

Published: Nov. 29, 2024

Gold nanoparticles have been identified as a promising avenue for the development of drug carriers, particularly in context antimicrobial delivery, where limited solubility represents significant challenge. The ability gold to penetrate biofilms and disrupt fungal cell membranes makes them an effective tool support antifungal therapy, especially against resistant strains. also demonstrate synergistic effects with chemotherapeutics can influence release profile active substances. This study aimed develop topical hydrogel formulation containing itraconazole (ITZ), addition nanoparticles, enhance its therapeutic properties. Due ITZ’s poor water solubility, three types (AuNPs) different sizes were synthesized subsequently coated itraconazole. resulting formulations incorporated into carbopol gels their diffuse through semipermeable was assessed. findings demonstrated that combination elevated diffusion coefficient twice level observed without nanoparticles. Furthermore, combined effect reference Candida albicans strain investigated. growth-inhibitory on this strain, indicating could potentially be employed treatment infections. confirms hydrogels obtained, offering enhanced diffusion.

Language: Английский

Citations

0