Synergistic Anticandidal Activities of Greenly Synthesized ZnO Nanomaterials with Commercial Antifungal Agents against Candidal Infections

Micromachines, Journal Year: 2023, Volume and Issue: 14(1), P. 209 - 209

Published: Jan. 14, 2023

The high occurrence of mycological resistance to conventional antifungal agents results in significant illness and death rates among immunodeficient patients. In addition, the underprivileged therapeutic agents, besides potential toxicity resulting from long term therapy necessitate fabrication efficient antimicrobial combinations. Hence, objective present investigation is synthesize, characterize investigate anticandidal action green zinc oxide nanoparticles (ZnO-NPs) formulated using Camellia sinensis leaf extract against three candidal pathogens. eco-friendly synthesized ZnO-NPs were characterized utilizing different physicochemical methods their potency was tested a disk diffusion assay. this setting, size biofabricated detected transmission electron microscope (TEM) micrographs, recording an average particle 19.380 ± 2.14 nm. zeta analysis revealed that surface charge −4.72 mV. biogenic reveal highest activity C. tropicalis strain, demonstrating relative suppressive zones measured at 35.16 0.13 37.87 0.24 mm diameter for concentrations 50 100 μg/disk, respectively. Excitingly, Candida glabrata showed susceptibility ZnO nanomaterials both ZnO-NPs’ (50 μg/disk) compared control. Moreover, biosynthesized synergistic effectiveness with nystatin terbinafine concerned strains. maximum efficiency noticed percentages 23.02 45.9%, no hemolytic human erythrocytes revealing biosafety hemocompatibility. Finally, pathogens, as well patterns such terbinafine, emphasize prospective application these combinations biocompatible highly agents.

Language: Английский

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Green Biofabrication of Silver Nanoparticles of Potential Synergistic Activity with Antibacterial and Antifungal Agents against Some Nosocomial Pathogens

Microorganisms, Journal Year: 2023, Volume and Issue: 11(4), P. 945 - 945

Published: April 4, 2023

Nosocomial bacterial and fungal infections are one of the main causes high morbidity mortality worldwide, owing to prevalence multidrug-resistant microbial strains. Hence, study aims synthesize, characterize, investigate antifungal antibacterial activity silver nanoparticles (AgNPs) fabricated using Camellia sinensis leaves against nosocomial pathogens. The biogenic AgNPs revealed a small particle diameter 35.761 ± 3.18 nm based on transmission electron microscope (TEM) graphs negative surface charge -14.1 mV, revealing repulsive forces between nanoparticles, which in turn indicated their colloidal stability. disk diffusion assay confirmed that Escherichia coli was most susceptible strain (200 g/disk), while lowest sensitive found be Acinetobacter baumannii with relative inhibition zones 36.14 0.67 21.04 0.19 mm, respectively. On other hand, µg/disk) exposed efficacy Candida albicans zone 18.16 0.14 mm diameter. synergistic both tigecycline clotrimazole A. C. albicans, In conclusion, demonstrated distinct physicochemical properties potential bioactivity tigecycline, linezolid, gram-negative, gram-positive, strains, This is paving way for development effective antimicrobial combinations management pathogens intensive care units (ICUs) health settings.

Language: Английский

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Breaking Barriers in Eco-Friendly Synthesis of Plant-Mediated Metal/Metal Oxide/Bimetallic Nanoparticles: Antibacterial, Anticancer, Mechanism Elucidation, and Versatile Utilizations

Journal of Nanomaterials, Journal Year: 2024, Volume and Issue: 2024, P. 1 - 48

Published: April 12, 2024

Nanotechnology has emerged as a promising field in pharmaceutical research, involving producing unique nanoscale materials with sizes up to 100 nm via physiochemical and biological approaches. Nowadays more emphasis been given eco-friendly techniques for developing nanomaterials enhance their applications minimize health environmental risks. With the help of green nanotechnology, wide range metal, metal oxide, bimetallic nanoparticles distinct chemical compositions, sizes, morphologies have manufactured which are safe, economical, environment friendly. Due biocompatibility vast potential biomedical (antibacterial, anticancer, antiviral, analgesic, anticoagulant, biofilm inhibitory activity) other fields such (nanofertilizers, fermentative, food, bioethanol production, construction field), garnered significant interest worldwide. The precursors combined natural extracts plants, algae, fungi, bacteria get potent novel Ag, Au, Co, Cu, Fe, Zr, Zn, Ni, Pt, Mg, Ti, Pd, Cd, Bi2O3, CeO2, Co3O4, CoFe2O4, CuO, Fe2O3, MgO, NiO, TiO2, ZnO, ZrO2, Ag-Au, Ag-Cr, Ag-Cu, Ag-Zn, Ag-CeO2, Ag-CuO, Ag-SeO2, Ag-TiO2, Ag-ZnO, Cu-Ag, Cu-Mg, Cu-Ni, Pd-Pt, Pt-Ag, ZnO-CuO, ZnO-SeO, ZnO-Se, Se-Zr, Co-Bi2O3. These plant-mediated possess excellent antibacterial anticancer activity when tested against several microorganisms cancer cell lines. Plants contain essential phytoconstituents (polyphenols, flavonoids, terpenoids, glycosides, alkaloids, etc.) compared sources (bacteria, algae) higher concentration that play vital role development because these plant-phytoconstituents act reducing, stabilizing, capping agent helps nanoparticles. After concluding all findings, this review designed first time way it imparts satisfactory knowledge about together, along mechanisms. Additionally, provides information characterization (UV–vis, FT-IR, DLS, XRD, SEM, TEM, BET, AFM) employed nanoparticles, applications, industries. Hence, various types versatile application diverse is not covered pieces literature.

Language: Английский

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Phytosynthesis via wasted onion peel extract of samarium oxide/silver core/shell nanoparticles for excellent inhibition of microbes

Heliyon, Journal Year: 2024, Volume and Issue: 10(3), P. e24815 - e24815

Published: Jan. 20, 2024

The aqueous onion peel extract (OPE) was used to synthesize silver nanoparticles (Ag-onion), samarium oxide (Sm2O3-onion), and silver/samarium core/shell (Ag@Sm2O3-onion). produced were characterized by thermal gravimetric analysis (TGA), infrared spectra (FT-IR), absorption (UV–Vis), energy band gap, X-ray photoelectron spectroscopy (XPS), diffraction (XRD), zeta potential, transmission electron microscopy (TEM). OPE NPs tested for the disinfection of some water microbes. XRD exhibited an amorphous structure in both Sm2O3-onion Ag@ Sm2O3-onion. isolated bacteria from sample Bacillus subtilis (OQ073500) Escherichia coli (MW534699), while fungi Alternaria brassicae (MZ266540), Aspergillus flavus (MT550030), penicillioides (MW957971), Pythium ultimum (MW830915), Verticillium dahlia (MW830379), Fusarium acuminatum (MZ266538), Candida albicans (MW534712), parapsilosis (MW960416). High levels antimicrobial activity seen extract. Based on experimental results, Ag@Sm2O3 demonstrated highest as effective disinfectant, indicating effectiveness modification process.

Language: Английский

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Green fabrication of ZnO nanoparticles via spirulina platensis and its efficiency against biofilm forming pathogens

Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)

Published: March 27, 2024

Abstract Excessive consumption of antibiotics is considered one the top public health threats, this necessitates development new compounds that can hamper spread infections. A facile green technology for biosynthesis Zinc oxide nanoparticles (ZnO NPs) using methanol extract Spirulina platensis as a reducing and stabilizing agent has been developed. bunch spectroscopic microscopic investigations confirmed biogenic generation nano-scaled ZnO with mean size 19.103 ± 5.66 nm. The prepared NPs were scrutinized their antibacterial antibiofilm potentiality, inhibition zone diameters ranged from 12.57 0.006 mm to 17.33 (at 20 µg/mL) variety Gram-positive Gram-negative pathogens, also significant eradication biofilms formed by Staphylococcus aureus Klebsiella pneumoniae 96.7% 94.8% respectively was detected. free radical scavenging test showed promising antioxidant capacity (IC 50= 78.35 µg/mL). Furthermore, anti-inflammatory role detected HRBCs-MSM technique revealed an efficient stabilization red blood cells in concentration-dependent manner. In addition, have anticoagulant antitumor activities well minimal cytotoxicity against Vero cells. Thus, study offered act secure substitute synthetic antimicrobials could be applied numerous biomedical applications.

Language: Английский

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A Comprehensive Review on Exploring the Potential of Phytochemicals and Biogenic Nanoparticles for the Treatment of Antimicrobial-Resistant Pathogenic Bacteria

Current Microbiology, Journal Year: 2025, Volume and Issue: 82(2)

Published: Jan. 18, 2025

Language: Английский

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Green Synthesis and Characterization of Zinc Oxide Nanoparticles Mediated by Nyctanthes arbor-tristis Leaf Extract: Exploring Antidiabetic, Anticancer, and Antimicrobial Activities

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 20, 2025

Language: Английский

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Rhizospheric nano-remediation salvages arsenic genotoxicity: Zinc-oxide nanoparticles articulate better oxidative stress management, reduce arsenic uptake, and increase yield in Pisum sativum (L.)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 913, P. 169493 - 169493

Published: Dec. 25, 2023

Language: Английский

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Synergistic Antibacterial Proficiency of Green Bioformulated Zinc Oxide Nanoparticles with Potential Fosfomycin Synergism against Nosocomial Bacterial Pathogens

Microorganisms, Journal Year: 2023, Volume and Issue: 11(3), P. 645 - 645

Published: March 2, 2023

The drug resistance of bacterial pathogens causes considerable morbidity and death globally, hence there is a crucial necessity for the development effective antibacterial medicines to address issue. bioprepared zinc oxide nanoparticles (ZnO-NPs) were prepared utilizing flower extract Hibiscus sabdariffa then characterized using different physicochemical techniques. effectiveness ZnO-NPs their synergism with fosfomycin evaluated disk diffusion assay against concerned pathogens. Transmission electron microscopy (TEM) investigation showed that average particle size was 18.93 ± 2.65 nm. Escherichia coli expressed highest sensitivity bioinspired suppressive zone 22.54 1.26 nm at concentration 50 µg/disk, whereas maximum synergistic effect noticed Klebsiella pneumoniae strain ratio 100.29%. In conclusion, demonstrated significant efficacy nosocomial pathogens, highlighting potential ZnO NPs-fosfomycin combination control infections in intensive care units (ICUs) health settings. Furthermore, biogenic ZnO-NPs’ action food such as Salmonella typhimurium E. indicates usage packaging applications.

Language: Английский

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Effective removal of textile dye via synergy of adsorption and photocatalysis over ZnS nanoparticles: Synthesis, modeling, and mechanism

Heliyon, Journal Year: 2024, Volume and Issue: 10(17), P. e36949 - e36949

Published: Aug. 28, 2024

Language: Английский

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