Optical Coherence Tomography Angiography (OCT-A): Emerging Landscapes in Neuro-Ophthalmology and Central Nervous System (CNS) Disorders DOI Creative Commons
Mobin Ibne Mokbul

IntechOpen eBooks, Journal Year: 2023, Volume and Issue: unknown

Published: June 29, 2023

Optical Coherence Tomography (OCT) is now being widely used in several branches of biomedical science ranging from ophthalmology to neurology. Emerging it, optical coherence tomography angiography (OCT-A) a noninvasive, depth-resolved imaging tool for the visualization retinal vascular changes. In field neuro-ophthalmology, OCT-A proves be superior than conventional Fluorescein (FA) or indocyanine green (ICGA). This chapter discussed role different neuro-ophthalmological and central nervous system (CNS) disorders including multiple sclerosis, non-arteritic anterior ischemic optic neuropathy (NAION), papilledema, papillitis, glaucoma, Parkinson’s disease, Alzheimer’s cerebral small vessel diseases, stroke. Since some neurologic conditions show consistent peripapillary macular capillary changes, can future useful physician’s armamentarium due its capability better delineation superficial deeper choroidal vasculatures. Furthermore, limitations, technical challenges, research directions are illustrated this chapter.

Language: Английский

Optical Coherence Tomography Angiography (OCTA) of the eye: A review on basic principles, advantages, disadvantages and device specifications DOI
Aristotle G. Koutsiaris, Vasilios Batis,

Georgia Liakopoulou

et al.

Clinical Hemorheology and Microcirculation, Journal Year: 2022, Volume and Issue: 83(3), P. 247 - 271

Published: Dec. 6, 2022

Optical Coherence Tomography Angiography (OCTA) is a relatively new imaging technique in ophthalmology for the visualization of retinal microcirculation and other tissues human eye. This review paper aims to describe basic definitions principles OCT OCTA most straightforward possible language without complex mathematical engineering analysis. done help health professionals various disciplines improve their understanding design further clinical research more efficiently. First, technical related terminology are described. Then, list advantages disadvantages, with special reference blood flow quantification limitations. Finally, an updated hardware software specifications some commercially available devices presented.

Language: Английский

Citations

24
Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review DOI Creative Commons
Devahuti R. Chaliha, Mauro Vaccarezza, Jason Charng

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 15, 2024

Migraine is one of the world's most debilitating disorders, and it has recently been shown that changes in retina can be a potential biomarker for disease. These detected by optical coherence tomography (OCT), which measures retinal thickness, angiography (OCTA), vessel density. We searched databases Google Scholar, ProQuest, Scopus, Web Science studies English using OCT OCTA migraineurs, search terms "optical tomography," "OCT," angiography," "OCTA" "migraine." found 73 primary studies, 11 reviews, 8 meta-analyses pertaining to findings migraineurs. They showed migraineurs had reduced thickness (via OCT), density, greater foveal avascular zone area OCTA) than controls. reflect perfusion compromise occurring as opposed healthy deficits were worse migraine-with-aura chronic migraine migraine-without-aura episodic migraine. Certain areas eye, such fovea, may more vulnerable these other parts. Direct comparison between study difficult because heterogeneity both methodology analysis. Moreover, almost all case-control cross-sectional, longitudinal cohort are needed determine cause effect pathophysiology OCT/OCTA findings. Current evidence suggests serve markers further research this field will hopefully enable us better understand vascular associated with migraine, perhaps also providing new diagnostic therapeutic biomarker.

Language: Английский

Citations

4
New marker for the detection of pre-retinopathy in patients with type 1 diabetes mellitus: systemic immuno-inflammation index DOI Creative Commons
Hazan Gül Kahraman, Yusuf Ziya Güven, Fahrettin Akay

et al.

BMC Ophthalmology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 19, 2025

Language: Английский

Citations

0
Optical coherence tomography angiography in patients with focal epilepsy DOI Creative Commons
Flora Rider, Alla Guekht, А. А. Шпак

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Purpose This study aims to compare optical coherence tomography angiography (OCTA) data in individuals with focal epilepsy and healthy investigate the effect of antiseizure medications (ASM) on OCTA data. Methods We examined 48 consecutive patients 46 controls. Area skeleton density superficial deep capillary plexuses macular area peripapillary radial plexus were measured. Results In general, no differences parameters found between groups individuals. A comparison without comorbid major depressive disorder revealed However, densities perfused retinal vascular bed region showed a negative association use valproates modifiers presynaptic release machinery, whereas only positive modulators voltage-gated sodium channels. Conclusion different effects various ASM bed. These findings suggest that could serve as potential biomarkers for assessing small vessels capillaries brain.

Language: Английский

Citations

0
Basic fibroblast growth factor gel preparation induces angiogenesis during wound healing DOI
Lanfang Li,

Qiuxiao Ma,

Junyu Mou

et al.

The International Journal of Artificial Organs, Journal Year: 2023, Volume and Issue: 46(3), P. 171 - 181

Published: Jan. 10, 2023

This study aimed to observe the effect of basic fibroblast growth factor (bFGF) gel preparation on wound repair in a full-thickness skin defect rat model and further explore its mechanism.The Wistar rats was created with circular wounds 20 mm or 10 diameter both sides spine. The animals were divided into normal, model, control gel, bFGF groups (300 IU/cm2). effects healing evaluated compared. Optical coherence tomography (OCT)-based angiography (OCTA) used investigate angiogenesis during healing. Western blotting, polymerase chain reaction (PCR), enzyme-linked immunosorbent assay (ELISA) kits detect levels vascular endothelial (VEGF) matrix metalloproteinases (MMP2 MMP9) surface significantly reduced area, promoted formation granulation tissue, accelerated group days 7 14, compared group. OCTA results showed that improved density, diameter, circumference. blot, PCR, ELISA could promote expression MMP2, MMP9, VEGF 14 after injury.bFGF promotes areas. Topical preparations can be developed for use repair.

Language: Английский

Citations

6
Associations between the retinal/choroidal microvasculature and carotid plaque in patients with CAD: An OCTA study DOI Creative Commons
Jing Jiang, Jin Wang,

Yucen Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e29107 - e29107

Published: April 1, 2024

To investigate the associations between retinal/choroidal microvasculature and carotid plaque in patients with CAD assessed by optical coherence tomography angiography (OCTA).

Language: Английский

Citations

2
Optical coherence tomography angiography in patients with bipolar disorder and major depressive disorder DOI
Mikhail Zinchuk, Sofya Popova, Alla Guekht

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 361, P. 409 - 414

Published: June 16, 2024

Language: Английский

Citations

2
Early Retinal Microvascular Changes Assessed with Swept-Source OCT Angiography in Type 1 Diabetes Patients without Retinopathy DOI Open Access
Pétra Eid, Catherine Creuzot‐Garcher, Serge Aho

et al.

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(7), P. 2687 - 2687

Published: April 4, 2023

Type 1 diabetes is a chronic disease that can lead to vision loss when diabetic retinopathy develops. Retinal microvascular alterations occur before the appearance of clinical signs on fundus examination. This study aimed analyze retinal vascular parameters optical coherence tomography angiography (OCT-A) in patients with type without comparison non-diabetic volunteers. cross-sectional was conducted at Dijon University Hospital from 2018 2020. Vascular densities were measured using macular OCT-A. In total, 98 and 71 volunteers enrolled. A statistically significant lower density inner circle found superficial capillary plexus (SCP) group (p < 0.01). There correlation between central deep (DCP) total daily insulin intake = 0.042); furthermore, use FreeStyle Libre (FSL) device associated higher both SCP 0.034 for outer density) DCP 0.01 p 0.023 density). microvascularization early-altered diabetes, FSL seemed preserve microvascularization.

Language: Английский

Citations

5
Retinal Microvascular Changes in Familial Hypercholesterolemia: Analysis with Swept-Source Optical Coherence Tomography Angiography DOI Open Access
Pétra Eid, Louis Arnould, Pierre‐Henry Gabrielle

et al.

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(6), P. 871 - 871

Published: May 26, 2022

Familial hypercholesterolemia (FH) is a common but underdiagnosed genetic disorder affecting cholesterol metabolism, leading to atherosclerotic disease. The relationship between retinal microvascular changes and the presence of atheroma in patients with FH (FH group), comparison volunteers without (CT needs further investigation. This cross-sectional study was conducted university hospital October 1, 2020 May 31, 2021. Cardiovascular data, including Coronary Artery Calcium (CAC) score, were recorded for patients. Macula angiograms acquired using swept-source optical coherence tomography angiography (SS OCT-A) analyze both superficial capillary plexus (SCP) deep (DCP). A total 162 eyes 83 enrolled group 121 78 CT group. statistically significant association found CAC score vessel density (β = −0.002 [95% CI, −0.004; −0.0005], p 0.010) length −0.00005 −0.00008; −0.00001], DCP. had significantly lower foveal avascular zone circularity index than multivariate analysis (0.67 ± 0.16 vs. 0.72 0.10 group, β 0.04 0.002; 0.07], 0.037). Retinal microvascularization altered vascular densities are modified according score.

Language: Английский

Citations

8
Reconstruction and Visualization of 5μm Sectional Coronal Views for Macula Vasculature in OptoVue OCTA DOI Creative Commons
Abdel-Razzak Al-Hinnawi, Ahmed BaniMustafa, Motasem Al-Latayfeh

et al.

IEEE Access, Journal Year: 2023, Volume and Issue: 11, P. 28280 - 28293

Published: Jan. 1, 2023

A Computerized Medical Image Processing (CMIP) method is proposed to address the current challenges of optical coherence tomography angiography (OCTA): (1) need for observing macula vasculature concerning natural curvature region; (2) generating OCTA frames at successive small depths in all layers; and (3) enhancing visibility blood vessels, particularly below outer retina region. The CMIP involves image preprocessing, reconstruction, enhancement stages. Twenty subjects were obtained from OCTA500 dataset, which was OptoVue machine. 20 comprise two fields view (FOV), right left eyes (OD OS), five common disorders. sequential enface images 5μm displayed. presentation enhanced depths. resulting new ophthalmic views enable: avoiding superimposition into a projection map; vessels; inspecting macula's 3D oval-shaped. can generate sectional coronal (MCV) every depth, clarifying way that has not been presented machines. Therefore, "tracking" propagation vessel network becomes possible. Furthermore, vessels' display depths, including deep choroid layers, enhanced. yields futuristic advantages would allow physician precisely inspect localization diffusion invariant OCTA's FOVs, disorder, OD or OS eye.

Language: Английский

Citations

4