A Modified Corona Score Using Lung Ultrasound to Identify COVID-19 Patients DOI Creative Commons
Costantino Caroselli, Michael Blaivas, Yale Tung‐Chen

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 14(1), P. 51 - 51

Published: Dec. 26, 2023

Background: COVID-19 continues to circulate around the world with multiple different strains being active at once. While diagnosis antigen and molecular testing is more readily available, there still room for alternative methods of diagnosis, particularly in out-of-hospital settings, e.g., home or nursing homes, low–medium income countries, where may not be available. Study Objectives: To evaluate performance two modified corona score compared a traditional approach identify patients COVID-19. Methods: This was retrospective multicenter study performed compare ability predict SARS-CoV-2 test results on nasopharyngeal swab between scores novel (modified 1 (M1CS) 2 (M2CS)). The M1CS included lung ultrasound (LUS) chest X-ray (CXR) results, while M2SC only utilized LUS findings without CXRs. Emergency physicians point-of-care physical examination upon admission emergency department. Results: Subjects positive were older had higher ferritin levels temperature lower diastolic blood pressure oxygen saturation. groups differed (p < 0.001 all). SARS-CoV-2-positive fewer pleural line irregularities = 0.025) but presented frequently an interstitial pattern CXRs 0.001). Conclusions: In our study, alone provided valuable contribution improved its than when CXR included. These suggest that resource-limited areas unavailable prohibitively expensive can utilize as sole imaging modality loss diagnostic pneumonia diagnosis.

Language: Английский

COVID-19 Lung Ultrasound Scores and Lessons from the Pandemic: A Narrative Review DOI Creative Commons
Luigi Maggi, Giulia De Fazio,

Riccardo Guglielmi

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(11), P. 1972 - 1972

Published: June 5, 2023

The WHO recently declared that COVID-19 no longer constitutes a public health emergency of international concern; however, lessons learned through the pandemic should not be left behind. Lung ultrasound was largely utilized as diagnostic tool thanks to its feasibility, easy application, and possibility reduce source infection for personnel. scores consist grading systems used guide diagnosis medical decisions, owning good prognostic value. In context pandemic, several lung emerged either new or modifications pre-existing ones. Our aim is clarify key aspects standardize their clinical use in non-pandemic context. authors searched on PubMed articles related “COVID-19”, “ultrasound”, “Score” until 5 May 2023; other keywords were “thoracic”, “lung”, “echography”, “diaphragm”. A narrative summary results made. are demonstrated an important triage, prediction severity, aid decisions. Ultimately, existence numerous leads lack clarity, confusion, absence standardization.

Language: Английский

Citations

3
Analysis of Chest X-ray for COVID-19 Diagnosis as a Use Case for an HPC-Enabled Data Analysis and Machine Learning Platform for Medical Diagnosis Support DOI Creative Commons
Chadi Barakat, Marcel Aach, Andreas Schuppert

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(3), P. 391 - 391

Published: Jan. 20, 2023

The COVID-19 pandemic shed light on the need for quick diagnosis tools in healthcare, leading to development of several algorithmic models disease detection. Though these are relatively easy build, their training requires a lot data, storage, and resources, which may not be available use by medical institutions or could beyond skillset people who most tools. This paper describes data analysis machine learning platform that takes advantage high-performance computing infrastructure support applications. is validated re-training previously published deep model (COVID-Net) new where it shown performance improved through large-scale hyperparameter optimisation uncovered optimal parameter combinations. per-class accuracy model, especially pneumonia, higher when using tuned hyperparameters (healthy: 96.5%; pneumonia: 61.5%; COVID-19: 78.9%) as opposed parameters chosen traditional methods 93.6%; 46.1%; 76.3%). Furthermore, speed-up shows major decrease time resources increase, from 207 min 1 node 54 distributed over 32 nodes, but highlights presence cut-off point communication overhead begins affect performance. developed intended provide field with technical environment developing novel portable artificial-intelligence-based support.

Language: Английский

Citations

2
B-Lines Lung Ultrasonography Simulation Using Finite Element Method DOI Creative Commons
Fellipe Allevato Martins da Silva, Eduardo Moreno Hernández, Wagner Coelho de Albuquerque Pereira

et al.

Diagnostics, Journal Year: 2022, Volume and Issue: 12(11), P. 2751 - 2751

Published: Nov. 10, 2022

Introduction: Lung Ultrasonography (LUS) is a fast technique for the diagnosis of patients with respiratory syndromes. B-lines are seen in response to signal reverberations and amplifications into sites peripheral lung fluid concentration or septal thickening. Mathematical models commonly applied biomedicine predict biological responses specific parameters. Objective: This study proposes Finite-Element numerical model simulate radio frequency ultrasonic lines propagated from normal infiltrated structures. For tissue medium, randomized inhomogeneous data method was used. The simulation implemented COMSOL® used Acoustic Pressure Time-Explicit models, which based on discontinuous Galerkin (dG). Results: RF signals, processed MATLAB®, resulted images horizontal A-lines vertical B-lines, were reasonably similar real images. Discussion: use materials good enough scattering response, others literature. useful impact infiltration characteristics appearance LUS

Language: Английский

Citations

3
Application of advanced bioimaging technologies in viral infections DOI Creative Commons
Yu Sun,

Can Cao,

Yilin Peng

et al.

Materials Today Physics, Journal Year: 2024, Volume and Issue: 46, P. 101488 - 101488

Published: June 24, 2024

Viruses are major pathogens responsible for a wide range of infectious diseases that may lead to global pandemics. The understanding structural underpinnings virions, molecular mechanisms infection and the pathogenesis viral is crucial exploring prophylactic therapeutic approaches disorders. Though latest developments in imaging techniques have equipped scientists with tools investigate infections unprecedented detail multiple spatial temporal resolutions, unveiling how particles dynamically interact host cells requires integrations strategies connecting complexity functional properties. Here, we aim delineate (1) diversity devices been applied investigation morphology structure, (2) contribution current revealing features life-cycle associated reactions, (3) potential systems diagnosis prognosis diseases. This review provides an essential overview bioimaging scenarios comes up instructions select appropriate methods virological studies based on specific objectives investigations. Additionally, discuss challenges opportunities microscopy promoting more insightful comprehension complexities between viruses hosts nano-scale range.

Language: Английский

Citations

0
Lung Ultrasound Efficacy in Monitoring Post-SARS-CoV-2 Pneumonia and Inflammatory Biomarkers in Pediatric Patients DOI Creative Commons
R. Chelcea, Mihaela Dediu,

Diana Dabica

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1296 - 1296

Published: Aug. 11, 2024

Background and Objectives: Recognizing the crucial gaps in our understanding of pediatric pneumonia post-SARS-CoV-2 infection, this study aimed to assess relationship between Pediatric Pneumonia Ultrasound Scores (PedPne) inflammatory biomarkers. The primary objective is evaluate predictive value PedPne comparison with biomarkers (IL-6 dNLR) for development patients following SARS-CoV-2 infection. Materials Methods: This longitudinal observational collected data from diagnosed after an acute SARS-CoV2 focused on analyzing changes scores markers such as IL-6 dNLR initial admission follow-up at 7 days. Statistical analysis involved calculating sensitivity, specificity, Area Under Curve (AUC) each biomarker, alongside regression determine their hazard ratios predicting development. Results: identified significant cutoff values 1.88 (sensitivity 77.0%, specificity 85.7%, AUC 0.802, p < 0.001), 6.1 pg/mL 70.3%, 92.9%, 0.869, score 3.3 75.7%, 78.6%, 0.794, 0.001). Conversely, NLR showed lower diagnostic performance (AUC 0.485, = 0.327). Regression further highlighted strong power these markers, showing a fourfold increase risk (HR 4.25, CI: 2.07–9.53, indicating more than twofold 2.53, 1.19–6.97, 0.006), associated doubling 2.60, 1.33–5.18, Conclusions: conclusively demonstrated that both ultrasound specific are predictors post-COVID-19 These findings advocate integration routine clinical assessments enhance accuracy management children

Language: Английский

Citations

0
Ten Questions on Using Lung Ultrasonography to Diagnose and Manage Pneumonia in the Hospital-at-Home Model: Part I—Techniques and Patterns DOI Creative Commons
Nin‐Chieh Hsu, Yu‐Feng Lin, Hung‐Bin Tsai

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2799 - 2799

Published: Dec. 13, 2024

The hospital-at-home (HaH) model delivers hospital-level acute care, including diagnostics, monitoring, and treatments, in a patient’s home. It is particularly effective for managing conditions such as pneumonia. Point-of-care ultrasonography (PoCUS) key diagnostic tool the HaH model, it often serves substitute imaging-based diagnosis setting. Both standard handheld ultrasound equipment are suitable lung (LUS) evaluation. Curvelinear linear probes typically used. Patient positioning depends on their clinical condition specific protocols. To enhance sensitivity, we recommend using at least 10-point protocols supported by studies Five essential LUS patterns should be identified, A-line, multiple B-lines (alveolar-interstitial syndrome), confluent B-lines, subpleural consolidation, consolidation with air bronchogram. Pleural effusion common, its internal echogenicity can indicate severity need invasive procedures. current evidence various etiologies types of pneumonia limited, but demonstrates good sensitivity detecting abnormal sonographic atypical pneumonia, tuberculosis, ventilator-associated Further setting required to validate generalize findings.

Language: Английский

Citations

0
Lung Ultrasound: A Leading Diagnostic Tool DOI Creative Commons
M. Demi,

Gino Soldati

Diagnostics, Journal Year: 2023, Volume and Issue: 13(10), P. 1710 - 1710

Published: May 12, 2023

Thoracic ultrasound is an important diagnostic tool employed by many clinicians in well-defined applications [...].

Language: Английский

Citations

0
Efficacy of low-intensity pulsed ultrasound in the treatment of COVID-19 pneumonia DOI Creative Commons
Li Wen, Xiao Li,

Zhibin Kong

et al.

Ultraschall in der Medizin - European Journal of Ultrasound, Journal Year: 2023, Volume and Issue: 44(06), P. e274 - e283

Published: July 19, 2023

As a public health emergency of international concern, coronavirus disease 2019 (COVID-19) still lacks specific antiviral drugs, and symptomatic treatment is currently the mainstay. The overactivated inflammatory response in COVID-19 patients associated with high risk critical illness or even death. Low-intensity pulsed ultrasound (LIPUS) can mitigate inflammation inhibit edema formation. We aimed to investigate efficacy LIPUS therapy for pneumonia.62 were randomly assigned group (LIPUS area - Group 1; self-control 2) an external control (Group 3). primary outcomes volume absorption rate (VAR) (AAR) lung CT images.After average duration 7.2 days, there significant differences AAR VAR between 1 2 (AAR 0.25 vs 0.12, p=0.013; 0.35 0.11, p=0.005), 3 p=0.047; 0.19, p=0.042). Neither nor was statistically different 3. After treatment, C-reactive protein, interleukin-6, leukocyte, fingertip arterial oxygen saturation (SaO2) improved 1, while only SaO2 increased.LIPUS reduced serum factor levels hospitalized patients, which might be major advancement pneumonia therapy.ZIEL: Für die Coronavirus-Erkrankung (COVID-19), einen internationalen Gesundheitsnotstand darstellt, gibt es immer noch keine spezifischen antiviralen Medikamente, und Hauptstütze ist derzeit symptomatische Behandlung. Die überaktivierte Entzündungsreaktion bei COVID-19-Patienten mit einem hohen Risiko für schweren Erkrankungsverlauf Mortalität verbunden. Niedrigenergetischer gepulster Ultraschall kann Entzündung lindern Ödembildung hemmen. Unser Ziel war es, Wirksamkeit der LIPUS-Therapie COVID-19-Pneumonie zu untersuchen.62 Patienten wurden nach dem Zufallsprinzip einer Behandlungsgruppe (LIPUS-Bereich – Gruppe Selbstkontroll-Bereich externen Kontrollgruppe (Gruppe 3) zugewiesen. Das primäre Outcome waren Volumenabsorptionsrate Flächenabsorptionsrate Pneumonie CT-Aufnahmen.Nach durchschnittlichen Behandlungsdauer von 7,2 Tagen gab signifikante Unterschiede zwischen 0,25 vs. 0,12, p=0,013; 0,35 0,11, p=0,005) sowie p=0,047; 0,19, p=0,042). Weder unterschieden sich statistisch Nach Behandlung verbesserten Werte C-reaktives Protein, Interleukin-6, Leukozyten arterielle Sauerstoffsättigung Fingerspitze, während nur Fingerspitze anstieg.Die verringerte Konzentration Entzündungsfaktoren im Serum hospitalisierten COVID-19-Patienten, wichtigen Fortschritt Therapie darstellen könnte.

Language: Английский

Citations

0
Lung ultrasound scan score can identify pulmonary embolism high risk in patients with COVID-19: a retrospective analysis from a single center DOI Creative Commons
Maria Coppola, Giuseppe Cardillo,

Marina Lugarà

et al.

Italian Journal of Medicine, Journal Year: 2023, Volume and Issue: 17(1)

Published: July 19, 2023

Background. Since the European Society of Cardiology (ESC) published guidelines to stratify risk pulmonary embolism (PE), main goal several physicians has been find a biomarker able identify patients with venous thromboembolism at high die. Increased levels pro-B-type natriuretic peptide (BNP) were suggested as useful biomarkers in ESC (i.e., 2014) PE death, but its role was not confirmed other guidelines. Lung Ultrasound Scan (LUS) diagnostic and prognostic test mortality for lung failure. The aim this study is evaluate pro- BNP together LUS evaluation COVID-19 particular regarding overall death. Patients Methods. We retrospectively analyzed records from 178 COVID-19, admitted our ward COVID Medicine Unit Ospedale del Mare town Napoli) between March 2020 May 2021. For study, we data all available on pro-BNP 120 patients. selected patients, deaths recorded. Results. Propensity Score Matching used minimize erase confounding factors. Data showed that an association serum thrombotic events neither present before nor after matching adverse outcomes found increased values LUS. Discussion. During first waves pandemic, severe failure frequently clinical acute complication inducing life-threatening evolution. Conclusions. An score and/or hospitalized while similar pro-BNP.

Language: Английский

Citations

0
A Modified Corona Score Using Lung Ultrasound to Identify COVID-19 Patients DOI Creative Commons
Costantino Caroselli, Michael Blaivas, Yale Tung‐Chen

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 14(1), P. 51 - 51

Published: Dec. 26, 2023

Background: COVID-19 continues to circulate around the world with multiple different strains being active at once. While diagnosis antigen and molecular testing is more readily available, there still room for alternative methods of diagnosis, particularly in out-of-hospital settings, e.g., home or nursing homes, low–medium income countries, where may not be available. Study Objectives: To evaluate performance two modified corona score compared a traditional approach identify patients COVID-19. Methods: This was retrospective multicenter study performed compare ability predict SARS-CoV-2 test results on nasopharyngeal swab between scores novel (modified 1 (M1CS) 2 (M2CS)). The M1CS included lung ultrasound (LUS) chest X-ray (CXR) results, while M2SC only utilized LUS findings without CXRs. Emergency physicians point-of-care physical examination upon admission emergency department. Results: Subjects positive were older had higher ferritin levels temperature lower diastolic blood pressure oxygen saturation. groups differed (p < 0.001 all). SARS-CoV-2-positive fewer pleural line irregularities = 0.025) but presented frequently an interstitial pattern CXRs 0.001). Conclusions: In our study, alone provided valuable contribution improved its than when CXR included. These suggest that resource-limited areas unavailable prohibitively expensive can utilize as sole imaging modality loss diagnostic pneumonia diagnosis.

Language: Английский

Citations

0