Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: 42(22), P. 12077 - 12089
Published: Oct. 10, 2023
Crude or semi-purified extracts of plants can play a significant role as antitumor agents. They were used stabilizing and reducing agents in the preparation silver nanoparticles (AgNPs) that allows these particles to have more efficient cytotoxic activity. In current study, extract
Language: Английский
The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(41), P. 10086 - 10102
Published: Oct. 3, 2024
Organic dyes-based photothermal agents (OPTAs) have received increasing attention as alternative to inorganic materials due their higher biocompatibility and extensive diversification. Maximizing nonradiative deexcitation channels is crucial improve the conversion efficiency (PCE) of OPTAs. This typically achieved through individual molecular design or collective enhancement using supramolecular strategies. Furthermore, therapy (PTT) generally relies on linear one-photon absorption light source by OPTA, with less consideration given nonlinear two-photon (2PA) strategies, despite potential benefits. Here, a synergistic strategy, which combines intramolecular intermolecular quenching, employed maximize diphenylamino-substituted distyryl dicyanobenzene (DSB), an outstanding two-photon-absorbing chromophore. One three DSB units been introduced conic
Language: Английский
Citations
0
Reviews in Inorganic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 25, 2024
Abstract Lung cancer is the second leading cause of mortality related to cancer. So, it very necessary explore novel strategies eradicate it. Currently, gold based medicinal compounds have emerged as remarkable anticancer agents and expressed strong potential against lung cell lines. This review provides a comprehensive overview history, advancements, recent state complexes in treatment We discuss biological evaluation relation with chemical structures numerous complexes, including those featuring thiosemicarbazone, N -heterocyclic imine, carbenes, steroidyl NHC, CAACs, carbamates, diphosphanes ligands. Gold complexes’ cytotoxicity has been assessed contrasted that standard drugs such auranofin cisplatin, special focus on IC 50 values for evaluating potency. targets deliver detailed understanding therapies, paving way future research clinical applications.
Language: Английский
Citations
0
Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 5985 - 5985
Published: Dec. 19, 2024
The rapid development of nanotechnology during the last two decades has created new opportunities to design and generate more advanced nanotheranostics with diversified capabilities for diagnosis, drug delivery, treatment response monitoring in a single platform. To date, several approaches have been employed order develop nanotheranostics. purpose this review is briefly discuss key components nanotheranostic systems, present conventional upcoming imaging therapeutic modalities that employ evaluate recent progress field cancer systems past five years (2020–2024). Special attention focused on their composition, specificity, potential multimodal therapy, vitro vivo characterization.
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1627 - 1627
Published: Dec. 23, 2024
Background/Objectives: The aim was to study the possibilities of biomedical application gadolinium oxide nanoparticles (Gd2O3 NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological safety using different human cell lines. Methods: powder Gd2O3 NPs obtained by a process thermal decomposition carbonate precipitated from nitrate solution, studied transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, scanning (SEM) with energy dispersive analyzer (EDX). activity concentrations optical spectroscopy (OS) method in photochemical degradation methylene blue dye upon irradiation an source. Biological on lines (keratinocytes, fibroblasts, mesenchymal stem cells (MSCs)) evaluation effect wide range NP metabolic proliferative cellular (MTT test, direct counting, dead assessment, visual assessment cytoarchitectonics). test migration model wound performed MSC culture. Results: According TEM data, size 2–43 nm, average 20 nm. XRD analysis revealed that f had cubic structure (C-form) (Ia3)¯ lattice parameter = 10.79(9) Å. showed high degree crystallinity. By investigating photooxidative presence red light irradiation, it found weak antioxidant which depended particle content solution. At concentration 10−3 M, highest observed when reaction rate constant photodegradation decreased 5.5% 9.4 × min−1. When solution increased 10−2 M source, changed pro-oxidant accompanied 15% increase degradation. Studies level regenerative potential NPs, stimulated fibroblast metabolism at (27% enhancement), keratinocyte M–10−5 enhanced proliferation 35% 10−4 M. Furthermore, accelerated MSCs, enhancing proliferation, promoting healing wound. Conclusions: results demonstrated redox-active towards This may be basis for further research develop nanomaterials based skin medicine generally.
Language: Английский
Citations
0
Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: 42(22), P. 12077 - 12089
Published: Oct. 10, 2023
Crude or semi-purified extracts of plants can play a significant role as antitumor agents. They were used stabilizing and reducing agents in the preparation silver nanoparticles (AgNPs) that allows these particles to have more efficient cytotoxic activity. In current study, extract
Language: Английский
Citations
1