Identifying potential biomarkers and molecular mechanisms related to arachidonic acid metabolism in vitiligo

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 26, 2025

Background Numerous studies have reported that dysregulation of fatty acid metabolic pathways is associated with the pathogenesis vitiligo, in which arachidonic metabolism (AAM) plays an important role. However, molecular mechanisms AAM vitiligo not been clarified. Therefore, we aimed to identify biomarkers and using bioinformatics methods. Methods The GSE75819 GSE65127 datasets were used this study as training validation sets, respectively, along 58 AAM-related genes (AAM-RGs). differentially expressed (DEGs) between lesional control groups set identified through differential expression analysis. A biomarker-based nomogram was constructed predict risk vitiligo. Results 15 overlapping candidate obtained DEGs AAM-RGs. Machine-learning algorithms six key PTGDS , PNPLA8 FAAH ABHD12 PTGS1 MGLL . In both regarded biomarkers. based on these showed potential for predicting Functional enrichment, immune cell infiltration, regulatory network analyses elucidate mechanisms. Conclusion conclusion, implicated influence These findings offer insights into treatment, although further research needed a comprehensive understanding.

Language: Английский

---

Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(2)

Published: April 16, 2025

Language: Английский

---

The Effect of Fatty Acid Desaturase on Cardiovascular Lipid Biomarkers Depends on Circulating ω-3 and ω-6 Polyunsaturated Fatty Acids in the UK Biobank

Nutrients, Journal Year: 2025, Volume and Issue: 17(6), P. 1089 - 1089

Published: March 20, 2025

Objectives: The objective of this study is to outline a framework for how fatty acids may be acting as mediators/suppressors and/or moderators an individual’s genetic predisposition cardiovascular lipid biomarkers. Methods: All UK Biobank participants with demographic and lifestyle variables, circulating lipids, NMR-measured acid data collected at the baseline visit (N = 229,859) were included in analyses. We fit four separate linear regression models, one each following common measures lipids: total cholesterol, HDL-c, LDL-c, triglycerides. Each model predicted lipids by FADS (a well-known desaturase gene complex) haplotype, addition individual ω-3 (DHA, non-DHA, total), ω-6 (LA, non-LA, or SFA factors additive (mediation/suppression) using interaction term (with FADS) (moderation). models adjusted wide range medical history variables evaluated against Bonferroni-adjusted significance level (p < 8.9 × 10−4). Results: Across 56 (four seven FAs two conceptual (mediation/suppression moderation)), we found evidence 19 moderation, 12 mediation, 16 suppression effects FADS–lipid relationship. For example, adjusting DHA levels mediator, association genotype HDL-c substantially lessened both minor genotypes reflecting >122% mediation DHA. Additionally, that LDL-c moderated, some extent, all measures. Conclusions: This analysis demonstrates profile can act mediator/suppressor moderator various Future work necessary expand cross-sectional examination determine directionality temporality moderation presented. research has been conducted Resource under Application Number 85092.

Language: Английский

---

Effect of daily avocado consumption for 6 mo compared with habitual diet on red blood cell fatty acid profiles and association with cardiometabolic risk factors in individuals with abdominal obesity: a randomized trial

American Journal of Clinical Nutrition, Journal Year: 2024, Volume and Issue: 120(4), P. 794 - 803

Published: Aug. 10, 2024

Avocado intake improves dietary fat quality, but the subsequent impact on red blood cell (RBC) saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA), and trans-fatty acid (TFA) composition association with cardiometabolic health, has not been elucidated. To compare effect of consuming 1 avocado/d relative to habitual diet (HAB) RBC-FA profiles, their visceral adiposity risk factors (CMRFs) in individuals abdominal obesity. profiling at baseline, 3- 6 mo was conducted participants (n = 994) from Habitual Diet Trial (HAT). HAT a multisite, free-living, parallel-arm intervention study which were randomly assigned either avocado-supplemented group (AVO, usual avocado/d) or HAB (usual limited avocado intake) for mo. Changes secondary outcome measure, determined within between groups using linear regression mixed models, adjusting age, sex, BMI, clinical site, smoking status, percentage energy baseline. The changes RBC-FAs CMRFs assessed after covariate FDR (<0.05) adjustment. No major differences profiles observed groups, exception MUFA cis-vaccenic [18:1n−7c], significantly higher AVO (β: 0.11 [0.05, 0.17]) compared 0.03 [−0.03, 0.08]) participants. In group, increases cis (18:1n−7c, oleic [18;1n−9c], erucic [22:1n−9c]) trans (palmitelaidic [16:1n−7t], vaccenic [18:1n−7t], elaidic [18:1n−9t], petroselaidic [18;1n−10-12t), as well PUFA γ-linolenic [18:3n−6], dihomo-γ-linolenic [20:3n−6], arachidonic [20:4n−6], α-linolenic [18:3n−3] associated unfavorable measures, lipid glucose, insulin high sensitivity C-reactive protein concentrations. Daily over 6-mo modified RBC–MUFA composition, notably 18:1n−7c, potentially mitigated some individual RBC-FA–CMRF associations time group. This trial registered https://clinicaltrials.gov/study NCT03528031.

Language: Английский

---

The Cardioprotective Effects of Polyunsaturated Fatty Acids Depends on the Balance Between Their Anti- and Pro-Oxidative Properties

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3937 - 3937

Published: Nov. 18, 2024

Polyunsaturated fatty acids (PUFAs) are not only structural components of membrane phospholipids and energy storage molecules in cells. PUFAs important factors that regulate various biological functions, including inflammation, oxidation, immunity. Both

Language: Английский

---

Genetic predisposition to metabolic dysfunction-associated fatty liver disease

CHILD`S HEALTH, Journal Year: 2024, Volume and Issue: 19(3), P. 162 - 174

Published: May 26, 2024

The literature review highlights the issue of genetic risk factors associated with development metabolic dysfunction-associated fatty liver disease. Human examinations revealed 132 genes among which 32 loci are strongly pathogenesis It has been found that developing disease is carried by single-nucleotide variants various whose products involved in lipid and carbohydrate metabolism, maintenance redox state, inflammation fibrosis tissue, components reactome. authors presented a detailed list singling out those influence directly steatohepatitis fibrosis. Also, they emphasized it protein 3 containing patatin-like phospholipase domain, transmembrane 6 superfamily member 2, 17b-hydroxysteroid dehydrogenase type 13 characte­rized highest degree association (odds ratio > 1.6) compared to other identified gene studies. combination several polymorphisms increases severity additive steatogenic effect domain 2 probably due an increased expression de novo lipogenesis. emphasize need for assessment disease, should include molecular testing at early stage examination.

Language: Английский

---

Saturated Fats: Time to Assess Their Beneficial Role in a Healthful Diet

Published: July 2, 2024

Saturated fats are widely seen as undesirable components of a healthy diet, result their illusive association with elevated serum cholesterol. The regulation cholesterol is now better understood and polyunsaturated fatty acids rather than saturated responsible. Palmitic acid received further specious allegations inciting inflammation when in fact it was found to play an auxiliary role precursor ceramide biosynthesis. Studies arthritic lab animals showed dietary anti-inflammatory, whereas oils pro-inflammatory. Inflammation plays numerous metabolic diseases, including insulin resistance, liver disease syndrome among others. Fat, triglycerides adipose tissue, efficient way for living organisms store energy reduce toxicity other macronutrients. However, tissue lipolysis releases into the blood provide many organs supply spare glucose brain tissue. Some disorders nonesterified blood, leading hepatic lipid accumulation, resistance. This paper will attempt clarify acids, palmitic particular, regard certain adverse health conditions.

Language: Английский

---

Identification of genes related to fatty acid metabolism in type 2 diabetes mellitus

Biochemistry and Biophysics Reports, Journal Year: 2024, Volume and Issue: 40, P. 101849 - 101849

Published: Oct. 22, 2024

Language: Английский

---

Saturated Fats: Time to Assess Their Beneficial Role in a Healthful Diet

Dietetics, Journal Year: 2024, Volume and Issue: 3(4), P. 452 - 462

Published: Oct. 29, 2024

Saturated fats are widely seen as undesirable components of a healthy diet, result their illusory association with elevated serum cholesterol. The regulation cholesterol is now better understood and lack polyunsaturated fatty acids, rather than an abundance saturated responsible. Palmitic acid was shown to incite inflammation at unnaturally high concentrations in tissue culture, but later found play auxiliary role precursor ceramide biosynthesis possibly the palmitoylation membrane receptors involved initiation inflammation. Studies arthritic lab animals showed that dietary anti-inflammatory, whereas oils pro-inflammatory. Inflammation plays numerous metabolic diseases, including insulin resistance, liver disease syndrome, among others. Fat, triglycerides adipose tissue, efficient way for living organisms store energy reduce toxicity other macronutrients. Macronutrients, such excess carbohydrates converted monounsaturated acids storage tissue. Fatty released from during fasting some disorders, where levels nonesterified blood can lead hepatic lipid accumulation, resistance. Although most may be they not necessarily derived diet. This paper will attempt clarify palmitic particular, regard certain adverse health conditions.

Language: Английский

---

Modern Views about the Association of Non-Alcoholic Fatty Liver Disease and Cardiovascular Pathology

Doctor Ru, Journal Year: 2024, Volume and Issue: 23(4), P. 27 - 31

Published: Jan. 1, 2024

Aim. Based on current literature data, to evaluate the association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD), consider pathophysiological mechanisms underlying this relationship, indicate methods for reducing cardiometabolic risk in patients with NAFLD. Key points. NAFLD occupies a leading position structure of chronic diseases, is one manifestations metabolic syndrome closely associated CVD. The relationship prevalence CVD has been established numerous studies. significantly more severe A number meta-analyses have documented direct mortality. Many development these two coincide. Some molecular changes that play an important role are also involved formation Patients often atherosclerosis, which underlies Conclusion. All modern international Russian recommendations management pay significant attention advisability screening need reduce through lifestyle modification (optimizing diet, weight loss, increasing physical activity), using statin medications, ursodeoxycholic acid ademetionine. Keywords: disease, steatosis, steatohepatitis, prevalence, factors.

Language: Английский

---