The Importance of Vaccination, Variants and Time Point of SARS-CoV-2 Infection in Pregnancy for Stillbirth and Preterm Birth Risk: An Analysis of the CRONOS Register Study

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1522 - 1522

Published: March 7, 2024

Background: The risk of preterm birth (PTB) and stillbirth increases after a SARS-CoV-2 infection during gestation. We aimed to estimate the depending on gestational age at (early <28 + 0 late ≥28 weeks gestation, WoG), virus variants, severity infection, vaccination. Methods: PTB was divided into early (<32 0) (32 0–36 6 WoG). prospective register COVID-19 Related Obstetrics Neonatal Outcome Study (CRONOS) included 8032 pregnant women with confirmed from 3 April 2020 31 December 2022, in Germany Austria. Results: Stillbirth births rates were higher Alpha (1.56% 3.13%) Delta 3.44%) waves than Omicron wave (0.53% 1.39%). Early increased for (aRR 5.76, 95% CI 3.07–10.83) before 32 (aRR, 6.07, 3.65–10.09). Hospital admission risks further, especially case ICU admission. Vaccination against significantly reduced 0.32, 0.16–0.83). Conclusions: This multicentric study shows an pregnancy therefore importance obstetrical surveillance thereafter. offers effective protection.

Language: Английский

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Chorioamnionitis: An Update on Diagnostic Evaluation

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2922 - 2922

Published: Oct. 28, 2023

Chorioamnionitis remains a major cause of preterm birth and maternal neonatal morbidity. We reviewed the current evidence for diagnostic tests chorioamnionitis how this relates to clinical practice today. A comprehensive literature search review was conducted on intra-uterine inflammation. Data from randomized control trials systematic reviews were prioritized. This highlights that sterile inflammation plays an important role in including criteria, plasma vaginal biomarkers lack accuracy. Concerningly, these often rely detecting inflammatory response after damage has occurred fetus. Care should be taken when interpreting investigations diagnosis they guide obstetric/neonatal management. There is urgent need further validation development novel, accurate, minimally invasive detect subclinical

Language: Английский

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SARS-CoV-2 Infection and Its Association with Maternal and Fetal Redox Status and Outcomes: A Prospective Clinical Study

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(5), P. 1555 - 1555

Published: Feb. 26, 2025

Background: The impact of the SARS-CoV-2 viral infection during pregnancy on fetus can be direct—transmitted through placenta—and indirect—creating unfavorable conditions for development because inflammation, micro-thrombosis, and hypercoagulation. Our study aimed to determine types frequency pathohistological changes in placental tissue SARS-CoV-2-positive pregnant women examine possible role oxidative stress prognosis delivery its maternal fetal complications. Methods: This prospective clinical included 50 divided into two groups, positive (COVID-19 group) negative (control group), from who we collected demographic, clinical, obstetric, biochemical pathologic data. Data about newborn characteristics were also collected, which anamnestic, Results: values superoxide anion radical index lipid peroxidation significantly different mothers concerning presence infection, while levels nitric oxide, peroxidation, reduced glutathione, dismutase newborns depending infection. Newborn similar between groups except concentrations IgM antibody. incidence FVM type COVID-19 group was 46%, control group, 18%. Conclusions: confirmed significant parameters stress-mediated dysfunction. Future studies should performed with more participants follow-up neonatal development.

Language: Английский

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Expression of Estrogen Receptors in Main Immune Organs in Sheep During Early Pregnancy

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3528 - 3528

Published: April 9, 2025

Estrogen exerts its action via estrogen receptors (ERs), including ERα and ERβ, has effects on immunomodulation during pregnancy. It is known that there are changes in the function of maternal immune organs However, it not clear if early pregnancy expression ERβ ovine thymus, lymph nodes, spleen, liver. In this study, these were harvested at day 16 estrous cycle days 13, 16, 25 (n = 6 for each group) after ewes euthanized. The mRNA protein analyzed using real-time PCR Western blot immunohistochemical analyses. results reveal both upregulated spleen liver was modulated conclusion, modulates a tissue-specific manner, which related to regulation ewes.

Language: Английский

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Long-Term Effects of COVID-19 on Women’s Reproductive Health and Its Association with Autoimmune Diseases, Including Multiple Sclerosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(9), P. 3057 - 3057

Published: April 29, 2025

Concern over COVID-19’s long-term influence on women’s reproductive health is growing, with emerging research suggesting potential links to ovarian dysfunction, menstrual irregularities, fertility challenges, and adverse pregnancy outcomes. Post-viral immune dysregulation linked both the development exacerbation of autoimmune diseases, including multiple sclerosis (MS). Long COVID has been associated immunological hormonal imbalances, chronic inflammation, all which may worsen disorders issues. characterized by symptoms persisting for weeks or months beyond acute infection phase. There are indications that prolonged contribute disease through mechanisms such as hyperactivation, molecular mimicry, dysregulated cytokine responses. Although this field still emerging, growing evidence suggests SARS-CoV-2 have lasting effects health, highlighting need further studies into its underlying clinical This review compiles recent findings impact COVID-19 association disorders, particularly MS.

Language: Английский

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Effects of the combination of exercise and education in the treatment of low back and/or pelvic pain in pregnant women: Systematic review and meta‐analysis

International Journal of Gynecology & Obstetrics, Journal Year: 2023, Volume and Issue: 164(3), P. 811 - 822

Published: July 21, 2023

Abstract Background Lumbopelvic pain is considered the most frequent complication during pregnancy. Objective To compare whether combination of exercise with education more effective for treatment low back and/or pelvic (PP) than each these interventions separately in pregnant women. Search Strategy A systematic review was performed WOS, PEDro, PubMed, Cochrane, and ClinicalTrials.gov . The terms used were pain, PP, pregnancy, woman, exercise, therapy, health education, prenatal education. Selection Criteria PICO question then chosen as follows: P—population: women nonspecific or PP; I—intervention: therapy plus education; C—control: only O—outcome: characteristics disability, kinesophobia; S—study designs: randomized controlled trial. Data Collection Analysis Two reviewers independently screened articles eligibility. following inclusion criteria applied selection studies: (i) published past 10 years; (ii) administered compared a group receiving either alone; (iii) sample consisted PP. This excluded: nonrandomized trials; whose full text not available. meta‐analysis using random‐effects model, due to observed heterogeneity. Main Results total 13 selected. There significant decrease alone (standardized mean difference, −0.29 [95% confidence interval, −0.47 −0.11]). With respect there that addressed −0.37 CI, −0.60 −0.14]). One article analyzed kinesophobia, reporting no changes. Conclusion seems be reducing disability PP use alone. In results found are significant.

Language: Английский

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Comparison of Maternal and Neonatal Outcomes between SARS-CoV-2 Variants: A Retrospective, Monocentric Study

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(19), P. 6329 - 6329

Published: Oct. 1, 2023

The impact of SARS-CoV-2 variants on maternal and neonatal outcomes during pregnancy is still poorly understood, the emergence different has further complicated our understanding virus’s effects. This retrospective, monocentric study aimed to fill this knowledge gap by analyzing pregnant women with acute infection caused Alpha, Delta, Omicron variants. study, conducted between December 2020 March 2022 at San Marco Hospital, included 313 confirmed infection. results showed that Delta variant was associated a significantly higher incidence adverse outcomes, such as premature births, intensive care unit admission, intrauterine growth restriction, small for gestational age infants. Additionally, linked lower Apgar scores, fetal mortality rates, increased levels various biomarkers indicating more severe illness. Finally, also presented greater possibility vertical transmission. These findings underscore complexity especially considering distinctive characteristics By better specific impacts each variant, appropriate preventive measures management strategies can be implemented optimize outcomes.

Language: Английский

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Maternal and Fetal Outcomes of COVID-19 According to the Trimester of Diagnosis: A Cross-Sectional Prospective Study in a Tertiary University Hospital

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(17), P. 5262 - 5262

Published: Sept. 5, 2024

Pregnant women are considered a high-risk group because they may be particularly susceptible to COVID-19. Our study tried relate fetomaternal outcomes and trimester-specific infection.

Language: Английский

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Risk Factors for Severe–Critical COVID-19 in Pregnant Women

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(18), P. 5812 - 5812

Published: Sept. 7, 2023

Risk factors associated with severe-critical COVID-19 (coronavirus disease 2019) are based on findings in the general population. Pregnant women at increased risk of infection, and few reports these women. A multicentric case-control study was conducted Mexican Institute Social Security, State Mexico, during pandemic. We included pregnant who were consecutively admitted to respiratory care units followed until 30 days after resolution pregnancy. total 758 a positive RT-PCR test for SARS-CoV-2 enrolled from June 2020 July 2021. defined groups using World Health Organization Severity Classification; cases (n = 123), controls subjects non-severe 635). Data gathered clinical files. multivariate logistic regression analysis used adjust odds ratios their 95% confidence intervals COVID-19. pregnancy non-vaccination (OR 10.18), blood type other than O 6.29), maternal age > 35 years 5.76), history chronic hypertension 5.12), gestational infection ≥ 31 weeks 3.28), multiparity 2.80).

Language: Английский

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Obstetric and Gynecological Admissions and Hospitalizations in an Italian Tertiary-Care Hospital during COVID-19 Pandemic: A Retrospective Analysis According to Restrictive Measures

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(22), P. 7097 - 7097

Published: Nov. 15, 2023

Background: The national lockdown and the different restrictions applied in 2020 during COVID-19 pandemic brought several changes to hospitalization procedures. aim of this study was evaluate patterns access emergency services a tertiary-care obstetric gynecological department (OG-ED) throughout 2020. Methods: A single-center retrospective comparative on data from January December carried out following timeframes: February (before pandemic), March June (nationwide period), July September (removal restrictive measures), October (regional lockdown) compared same periods 2019. All patients with complete medical admitted OG-ED were included. Results: Overall, 4233 accesses for 2019 3652 reported, decreasing trend −13.7%. Between 2019, overall number attending decreased July–September October–December differences (Δ −23.5% vs. −3.1% −5.9%; p = 0.001 respectively) 2020–2019, but reduction not statistically significant when January–February −18.5%; 0.356). No −1.8% −1.0% −2.3% +1.9% respectively; 0.883) noted. Hospitalizations showed stable an increase between +4.6%; (+2.4%) March–June (+2.6%) 2019–2020), mainly related regional lockdowns. Conclusions: In contrast available studies, our institution, rate admissions slightly reduced similar decrease even before COVID-19, serious issues, despite expectations that suspension elective outpatient would have led non-urgent hospitalizations period.

Language: Английский

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