Imaging Recommendations for Diagnosis, Staging, and Management of Primary Central Nervous System Neoplasms in Adults DOI Creative Commons
Kajari Bhattacharya, Abhishek Mahajan

Neuroglia, Journal Year: 2024, Volume and Issue: 5(4), P. 370 - 390

Published: Oct. 1, 2024

Central nervous system (CNS) neoplasms are a vast and diverse group of tumors in adults with variable prognoses depending on histology increasingly understood molecular features. There has been major paradigm shift the approach towards these ever since implications features have recognized. Gliomas primary CNS adults, glioblastomas significant cause morbidity mortality, especially older patients. Apart from gliomas, meningiomas pituitary other groups. This review aims to elucidate role imaging screening, diagnosis, management, follow-up neoplasms, an elaborate discussion artificial intelligence advanced techniques future directions likely play pivotal this ever-evolving subspecialty oncology.

Language: Английский

Potential of TSPO radioligands: Bridging brain tumor diagnostics to the peripheries DOI Creative Commons
François Avry, Clément Rousseau, Françoise Kraeber‐Bodéré

et al.

Biochimie, Journal Year: 2024, Volume and Issue: 224, P. 114 - 119

Published: May 9, 2024

Translocator protein (TSPO) is involved in several cellular mechanisms such as steroidogenesis, immunomodulation, cell proliferation and differentiation. Overexpressed neurodegenerative diseases brain cancer, TSPO radioligands have been developed over the last 20 years positron emission tomography (PET) imaging. Recently, extended beyond their initial application due to specific binding activated macrophages, making them a compelling biomarker for deciphering intricacies of tumor microenvironment (TME). In this review, we synthesized recent progress from evaluation TSPO-specific PET tracers various peripheral models highlighted hurdles limitations associated with heterogeneous uptake healthy tissue regions achieve clinical development radiotracer.

Language: Английский

Citations

4
Assessing diagnostic accuracy and monitoring of caries progression using Optical Coherence Tomography (OCT): A Systematic Review DOI
Abdulrahman A. Balhaddad,

Faisal Alharamlah,

Hassan F Albrahim

et al.

Journal of Dentistry, Journal Year: 2025, Volume and Issue: unknown, P. 105628 - 105628

Published: Feb. 1, 2025

Language: Английский

Citations

0
Translocator protein (TSPO) in glioma: implications for diagnosis, disease progression monitoring, and targeted therapies DOI Creative Commons

Julius Mulumba,

Bo Luo, Jiang Wu

et al.

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: 4

Published: April 1, 2025

Glioma is a highly aggressive brain cancer associated with significant mortality. Despite advances in diagnostic and therapeutic strategies, the prognosis for glioma patients remains poor due to limited accuracy monitoring capabilities. Translocator protein (TSPO) mitochondrial implicated various cancers, including glioma, where it plays role cell survival, proliferation, chemo-resistance. This review article aimed comprehensively analyze of TSPO particularly its potential applications enhancing methods strategies. Molecular imaging techniques have emerged as promising tools non-invasive diagnosis, disease progression monitoring, treatment selection gliomas. A comprehensive literature was conducted explore TSPO’s expression patterns, biological functions, molecular imaging. Studies utilizing positron emission tomography (PET), single photon computed (SPECT), magnetic resonance (MRI), other modalities were included. overexpressed cells, high-grade tumors, correlating tumor aggressiveness patient prognosis. TSPO-targeted agents demonstrate high specificity sensitivity detection, positioning marker accurate diagnosis monitoring. Future studies should focus on optimizing protocols, validating their clinical utility, exploring combined improve precision.

Language: Английский

Citations

0
Advances in liquid biopsy and virtual biopsy for care of patients with glioma: a narrative review DOI
Muhammad Awais, Abdul Rehman,

Syed Sarmad Bukhari

et al.

Expert Review of Anticancer Therapy, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 22

Published: April 5, 2025

The World Health Organization's 2021 classification of central nervous system neoplasms incorporated molecular and genetic features for classifying gliomas. Classification gliomas located in deep-seated structures became a clinical conundrum given the absence crucial pathological data. Advances noninvasive imaging modalities offered virtual biopsy as novel solution to this problem by identifying surrogate radiomic signatures. Liquid biopsies blood or cerebrospinal fluid provided another enormous opportunity genomic, metabolomic proteomic We summarize appraise current state evidence with regards liquid care patients PubMed, Embase Google Scholar were searched on 7/30/2024 relevant articles published after year 2013 English language. A large body preclinical preliminary suggests that is possible combined use multiple conjunction machine learning radiomics. Likewise, focused ultrasound may be valuable tool obtain genomic data regarding glioma minimally invasive manner. These will likely become an integral part future.

Language: Английский

Citations

0
Gliomagenesis, Epileptogenesis, and Remodeling of Neural Circuits: Relevance for Novel Treatment Strategies in Low- and High-Grade Gliomas DOI Open Access

Alessandro Grimi,

Beatrice Bono,

Serena Marita Lazzarin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8953 - 8953

Published: Aug. 16, 2024

Gliomas present a complex challenge in neuro-oncology, often accompanied by the debilitating complication of epilepsy. Understanding biological interaction and common pathways between gliomagenesis epileptogenesis is crucial for improving current understanding tumorigenesis also developing effective management strategies. Shared genetic molecular mechanisms, such as IDH mutations dysregulated glutamate signaling, contribute to both tumor progression seizure development. Targeting these pathways, through direct inhibition mutant enzymes or modulation receptors, holds promise patient outcomes. Additionally, advancements surgical techniques, like supratotal resection guided connectomics, offer opportunities maximally safe enhanced control. Advanced imaging modalities further aid identifying epileptogenic foci tailoring treatment approaches based on tumor's metabolic characteristics. This review aims explore interplay gliomagenesis, epileptogenesis, neural circuit remodeling, offering insights into shared innovative strategies improve outcomes patients with gliomas associated

Language: Английский

Citations

3
Immuno-PET for Glioma Imaging: An Update DOI Creative Commons
Maria Silvia De Feo,

Giorgia Maria Granese,

Miriam Conte

et al.

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(4), P. 1391 - 1391

Published: Feb. 8, 2024

Despite significant advances in glioma diagnosis and treatment, overall outcomes remain suboptimal. Exploring novel therapeutic avenues show promise advancing the field. Theranostics, an evolving discipline integrating therapy, emerges as a particularly auspicious approach. However, unmet need exists for glioma-associated biomarkers theranostic targets. Immuno-positron emission tomography (Immuno-PET), pioneering method uniting PET diagnostic precision with antibody specificity, holds potential identifying cancer-associated biomarkers. This review aims to provide updated overview of immuno-PET applications gliomas. Notably, [44Sc]-CHX-A″-DTPA-Cetuximab-Fab targeting Epidermal Growth Factor Receptor (EGFR) has displayed xenografts, enabling imaging at 4 h post-injection. Similarly, [89Zr]-bevacizumab vascular endothelial growth factor (VEGF) yielded encouraging results preclinical models clinical trial pediatric patients diffuse intrinsic pontine (DIPG). Several cell differentiation markers, including CD146, indicative tumor aggressiveness, CD11b, reflecting tumor-associated myeloid cells (TAMCs), proved effective targets immuno-PET. Additionally, directed prostate-specific antigen (PSMA) demonstrated efficacy neovasculature. While holding precise treatment guidance, challenges persist achieving target specificity selecting suitable radionuclides. Further studies are imperative advance field bridge translational gap from bench bedside.

Language: Английский

Citations

1
Neuro-Oncology and Positron Emission Tomography: “Just Can’t Get Enough” DOI Open Access
Barbara Muoio, Vittoria Espeli, Giorgio Treglia

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(19), P. 4739 - 4739

Published: Sept. 27, 2023

Imaging has a pivotal role in neuro-oncology for the management of primary and secondary brain tumors [...].

Language: Английский

Citations

3
[18F]Fluorocholine PET/CT false positive: foreign body reaction mimicking anaplastic glioma progression. A case report DOI Creative Commons
Teodoro Rudolphi‐Solero, Eva María Triviño Ibáñez, José Pablo Martínez Barbero

et al.

The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Journal Year: 2023, Volume and Issue: 59(1)

Published: Sept. 28, 2023

Abstract Background Foreign body reaction in brain tissue is a very rare immune response that has not been well studied. Hemostatic material reported as possible trigger of this other organs and could be detected by [ 18 F]fluorodeoxyglucose positron emission tomography/computerized tomography ([ F]FDG PET/CT), but there no experience about the role F]fluorocholine finding. F]Fluorocholine potential to differentiate viable central nervous system tumors from entities, so it frequently used follow-up neurosurgery patients. Case presentation A right frontoparietal neoplastic lesion was found young-aged patient with analgesic refractory headache. Surgical resection postsurgical radiotherapy were performed, pathologist analysis turned out cellular ependymoma signs anaplasia. In follow-up, an magnetic resonance imaging (MRI) showed suspicious lesion, PET/CT performed. Increased uptake described parietal region on margin residual cystic lesion. The got complete which confirmed later MRI. pathology analysis, focally congestive cerebral parenchyma histiocytic foreign area described. Conclusions Following current case report, also show false positive related reaction. This entity should considered avoid unnecessary major surgery our

Language: Английский

Citations

1
Translocator protein expression and localization in human endometrium and endometriosis: A potential target for a noninvasive diagnosis? DOI
Maíra Casalechi, Cynthia Dela Cruz, Wiviane A. Assis

et al.

Cell Biology International, Journal Year: 2024, Volume and Issue: 48(6), P. 898 - 906

Published: March 21, 2024

Abstract The limitations of current imaging methods to detect small or superficial endometriotic lesions prompt the search for new molecular targets. TSPO is an 18 KDa protein located in outer mitochondrial membrane, which can be traced by positron emission tomography (PET) using specific ligands. mostly neurons and inflammatory sites outside brain. We hypothesized that it might also expressed human endometrium endometrial‐like tissue, being a target endometriosis. This prospective cross‐sectional study included 28 women with endometriosis 11 endometriosis‐free controls. Endometriotic ( n = 49) normal peritoneum 13) from patients were obtained during laparoscopy, while samples eutopic 28) control 11) collected operating room flexible device. mRNA expression was evaluated quantitative reverse‐transcription real‐time PCR immunohistochemistry monoclonal antibody antihuman TSPO. detected invariable fashion all tissue types evaluated; however, found more abundant glandular epithelium than stroma, both lesions. Interestingly, hormone therapies did not alter TSPO, its presence negative tissues adjacent implants. As proof concept, pattern along areas suggests TSPO‐based used noninvasive detection.

Language: Английский

Citations

0
Imaging Recommendations for Diagnosis, Staging, and Management of Primary Central Nervous System Neoplasms in Adults DOI Creative Commons
Kajari Bhattacharya, Abhishek Mahajan

Neuroglia, Journal Year: 2024, Volume and Issue: 5(4), P. 370 - 390

Published: Oct. 1, 2024

Central nervous system (CNS) neoplasms are a vast and diverse group of tumors in adults with variable prognoses depending on histology increasingly understood molecular features. There has been major paradigm shift the approach towards these ever since implications features have recognized. Gliomas primary CNS adults, glioblastomas significant cause morbidity mortality, especially older patients. Apart from gliomas, meningiomas pituitary other groups. This review aims to elucidate role imaging screening, diagnosis, management, follow-up neoplasms, an elaborate discussion artificial intelligence advanced techniques future directions likely play pivotal this ever-evolving subspecialty oncology.

Language: Английский

Citations

0