Is There a Role for FAPI PET in Urological Cancers? DOI Creative Commons
Naima Ortolan, Luca Urso,

Ilaria Zamberlan

et al.

Molecular Diagnosis & Therapy, Journal Year: 2024, Volume and Issue: 28(6), P. 721 - 725

Published: Aug. 24, 2024

This work aims to investigate the utility of positron emission tomography/computed tomography (PET/CT) with fibroblast activation protein inhibitors (FAPI) in urological neoplasms, including prostate cancer, urothelial carcinoma, and renal cell carcinoma. Although available data are very preliminary, FAPI PET showed potential for detecting primary cancer low prostate-specific membrane antigen expression, while PET/CT outperformed biochemical recurrence. In demonstrated increased detection rates compared deoxy-2-[18F]fluoro-d-glucose PET/CT, particular small lymph node metastases, whose identification is still an unmet clinical need. Limited conclusion, emerges as a promising imaging modality bladder cancer. Further research warranted establish its role guiding therapeutic decisions novel theranostic agent.

Language: Английский

Radiomolecular Theranostics With Fibroblast-Activation-Protein Inhibitors and Peptides DOI
Richard P. Baum, Emil Novruzov, Tianzhi Zhao

et al.

Seminars in Nuclear Medicine, Journal Year: 2024, Volume and Issue: 54(4), P. 537 - 556

Published: July 1, 2024

Language: Английский

Citations

10
Imaging of pleural disease DOI Open Access
Maged Hassan, Abdelfattah Touman, Elżbieta M. Grabczak

et al.

Breathe, Journal Year: 2024, Volume and Issue: 20(1), P. 230172 - 230172

Published: March 1, 2024

The pleural space is a “potential” anatomical which formed of two layers: visceral and parietal. It normally contains trace fluid (∼10 mL in each hemithorax). Diseases the pleura can manifest with thickening membranes or by abnormal accumulation air liquid. Chest radiographs are often first imaging tests to point pathology. With exception pneumothorax, due inherent limitations chest radiographs, ultrasound and/or computed tomography usually required further characterise pathology guide management. This review summarises utility different tools management disease discusses new evolving pleura.

Language: Английский

Citations

9
First Clinical Experience of 68Ga-FAPI PET/CT in Tertiary Cancer Center: Identifying Pearls and Pitfalls DOI Creative Commons
Akram Al‐Ibraheem, Ahmed Saad Abdlkadir,

Ula Al-Rasheed

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 218 - 218

Published: Jan. 19, 2025

Background/Objectives: Over the past four years, 68Ga-fibroblast activation protein inhibitor (FAPI) positron emission tomography/computed tomography (PET/CT) has been established at a tertiary cancer care facility in Jordan. This retrospective study aims to explore tracer uptake metrics across various epithelial neoplasms, identify diagnostic pitfalls associated with 68Ga-FAPI PET/CT, and evaluate influence of PET/CT staging results on changes therapeutic intent compared gold standard molecular imaging modalities. Methods: A total 48 patients biopsy-confirmed solid tumors underwent 77 examinations for assessment, encompassing neoplasms originating from gastrointestinal tract, head neck, hepatobiliary system, pancreas, breast, lung. Results: Notably, pancreaticobiliary exhibited highest uptake, mean maximum standardized values (SUVmax) tumor-to-background ratios (TBR) surpassing 10. comparative sub-analysis PET 20 treatment-naïve revealed significant correlation between tumor grade (Spearman’s rho 0.83; p = 0.00001). Importantly, influenced treatment decisions 35.5% cases, primarily resulting an escalation management plans. 220 challenges were identified 88.3% scans, predominantly within musculoskeletal attributed degenerative (99 observations). Conclusions: comprehensive analysis highlights potential significance oncological strategy, while also emphasizing necessity meticulous interpretation mitigate challenges.

Language: Английский

Citations

1
Clinical applications of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET) DOI Creative Commons
Yuriko Mori, Emil Novruzov, Dominik Schmitt

et al.

npj Imaging, Journal Year: 2024, Volume and Issue: 2(1)

Published: Nov. 13, 2024

Abstract The discovery of fibroblast activation protein inhibitor positron emission tomography (FAPI-PET) has paved the way for a new class PET tracers that target tumor microenvironment (TME) rather than itself. Although 18 F-fluorodeoxyglucose (FDG) is most common tracer used in clinical imaging cancer, multiple studies have now shown family FAP ligands commonly outperform FDG detecting cancers, especially those known to lower uptake on FDG-PET. Moreover, FAPI-PET will applications benign fibrotic or inflammatory conditions. Thus, even while are development and yet enter guidelines, significant body literature emerged FAPI-PET, suggesting it important roles. This article summarizes current state as well potential uses theranostic agent.

Language: Английский

Citations

8
Cancer-associated fibroblasts: protagonists of the tumor microenvironment in gastric cancer DOI Creative Commons

Ece Ozmen,

Tevriz Dilan Demir, Gülnihal Özcan

et al.

Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11

Published: March 18, 2024

Enhanced knowledge of the interaction cancer cells with their environment elucidated critical role tumor microenvironment in progression and chemoresistance. Cancer-associated fibroblasts act as protagonists microenvironment, fostering metastasis, stemness, chemoresistance attenuating anti-cancer immune responses. Gastric is one most aggressive cancers clinic, refractory to therapies. Growing evidence indicates that cancer-associated are prominent risk factors for a poor dismal prognosis gastric cancer. Therefore, targeting may be central surpassing resistance conventional chemotherapeutics, molecular-targeted agents, immunotherapies, improving survival However, heterogeneity complicate development fibroblast approaches. Although single-cell sequencing studies started dissecting fibroblasts, research community should still answer these questions: “What makes protumorigenic?”; “How do intracellular signaling secretome different subpopulations differ from each other?”; “Which subtypes predominate specific types?”. Unveiling questions can pave way discovering efficient strategies. Here, we review current perspectives on questions, focusing how CAFs induce aggressiveness therapy We also potential therapeutic approaches prevent activation via inhibition CAF inducers markers

Language: Английский

Citations

5
Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy DOI

Shreya Bendre,

Helen Merkens,

Hsiou‐Ting Kuo

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 268, P. 116238 - 116238

Published: Feb. 13, 2024

Language: Английский

Citations

4
Investigating the diffuse pancreatic expression of [68Ga]Ga-DOTA-FAPI: location, timing, and molecular imaging approaches DOI
Akram Al‐Ibraheem,

Mohannad Badarneh,

Ahmed Saad Abdlkadir

et al.

Clinical and Translational Imaging, Journal Year: 2024, Volume and Issue: 12(5), P. 451 - 455

Published: April 23, 2024

Language: Английский

Citations

4
A FAPα-activated MRI nanoprobe for precise grading diagnosis of clinical liver fibrosis DOI Creative Commons

Jiahao Gao,

Ya Wang,

Xianfu Meng

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Sept. 13, 2024

Molecular imaging holds the potential for noninvasive and accurate grading of liver fibrosis. It is limited by lack biomarkers that strongly correlate with fibrosis grade. Here, we discover fibroblast activation protein alpha (FAPα) through transcriptional analysis biological assays on clinical samples. The mRNA expression FAPα are linearly correlated grade (R

Language: Английский

Citations

4
Monomeric or Homodimer Conjugates of Fibroblast Activation Protein Inhibitor and Cyanine 7 Bearing a Meso-Chloride as Near-Infrared Fluorescence Probes: Design, Synthesis, and Comparative In Vivo Imaging of Distinct Breast Cancer Subtypes DOI
Panpan Chen,

Zhipeng Lu,

Xiaowei Feng

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Intraoperative fluorescence navigation can illuminate the tumor, directing surgeons to accurately achieve negative margins, which not only reduces recurrence but also minimizes incidence of complications. Herein, we developed two near-infrared fluorescent probes FAPI-Cy7-Cl (Emmax = 820 nm) and (FAPI)2-Cy7-Cl 823 with prolonged tumor retention (>72 h) high target-to-background ratios (up 4.5) based on conjugation pan-cancer targeted fibroblast activation protein inhibitor (FAPI) "tumor-seeking" Cyanine 7 bearing a meso-chloride cyclohexenyl skeleton (Cy7-Cl). Specifically, exhibited superior imaging performance in both estrogen receptor α positive breast cancer (MCF-7) triple-negative (TNBC) (MDA-MB-231) subtypes mouse models. Notably, MDA-MB-231 tumor-bearing model, tumor-to-liver ratio (T/L) increased rapidly after 2 h postinjection, reaching nearly 4.5 at 48 h, making it an optimal probe for guiding TNBC surgery resection.

Language: Английский

Citations

0
Autoradiography of Intracerebral Tumours in the Chick Embryo Model: A Feasibility Study Using Different PET Tracers DOI Creative Commons
Sandra Krause, Alexandru Florea, Chang‐Hoon Choi

et al.

Molecular Imaging and Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Purpose In addition to rodent models, the chick embryo model has gained attention for radiotracer evaluation. Previous studies have investigated tumours on chorioallantoic membrane (CAM), but its value imaging of intracerebral yet be demonstrated. Procedures Human U87 glioblastoma cells and U87-IDH1 mutant glioma were implanted into brains embryos at developmental day 5. After 12–14 days tumour growth, blood–brain-barrier integrity was evaluated in vivo using MRI contrast enhancement or ex with Evans blue dye. The tracers O-(2-[ 18 F]fluoroethyl)-L-tyrosine ([ F]FET) ( n = 5), 3,4-dihydroxy-6-[ F]-fluoro-L-phenylalanine F]FDOPA) 3), [ 68 Ga] labelled quinoline-based small molecule fibroblast activation protein inhibitor Ga]FAPI-46) 4) injected intravenously if solid detected MRI. For time-activity curves F]FET, additional micro PET (µPET) performed. sacrificed 60 min post-injection, cryosections tumour-bearing produced autoradiography immunohistochemistry. Results Intracerebral a 100% success rate viable experimental endpoint. However, 52% 85) did not survive procedure embryonic development 20. radiotracers, tumour-to-brain ratios (TBR) derived from autoradiography, as well tracer kinetics µPET tumours, comparable those previously reported rodents patients: TBRmean F]FET 1.69 ± 0.54 3.8 one hypermetabolic < 2.0 two isometabolic tumors F]FDOPA, 1.92 1,11 3). Ga]FAPI-46 19.13 0.64 4). An intact blood-tumour barrier observed U87-MG 5). Conclusions Radiotracer offers fast evaluation uptake, accumulation, kinetics. Our results indicate high comparability between xenograft models brain patients.

Language: Английский

Citations

0