MCMC-Driven mathematical modeling of the impact of HPV vaccine uptake in reducing cervical cancer

Scientific African, Journal Year: 2025, Volume and Issue: unknown, P. e02633 - e02633

Published: March 1, 2025

Language: Английский

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Prognostic Significance of CDK1 in Ovarian and Cervical Cancers

Journal of Cancer, Journal Year: 2025, Volume and Issue: 16(5), P. 1656 - 1667

Published: Feb. 10, 2025

Background: Ovarian cancer (OC) and cervical (CC) are the leading causes of death among women. Therefore, identifying markers for early detection treatment is critical. CDK1 governs G2/M transition cell cycle a significant regulatory protein cycle. RO-3306 UBE2C related to expression might jointly facilitate development OC. CDK2 phosphorylate MLK3, which plays an important role in invasion proliferation OC cells. Furthermore, miR-490-3P targets restrains growth ovarian tumors. also crucial part progression CC. For instance, overexpression can rescue effect RCC1 knockdown, involved key processes, such as cytoplasmic transport, on G1 progression. Using bioinformatics analysis, we evaluated functional enrichment co-expressed gene these two cancers its impact their prognoses. Methods: First, screened public datasets OC- CC-associated DEGs identified intersecting genes. Enrichment analyses genes revealed biological pathways processes. We then generated protein-protein interaction networks identify central modules. Results: Additional that regulation germ maturation were primary processes regulated by core examined function CC, demonstrating association with particular immunological infiltration patterns. mutational burden, copy number variation, patient survival indicated may be useful prognostic marker. Finally, immunohistochemical examination confirmed some candidate clinical samples. Conclusion: These findings shed light molecular CC will aid identification novel future research regarding cancers, including diagnosis treatment.

Language: Английский

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Approach to P16 and Ki-67 in the Cervical Intraepithelial Neoplasia staging

Ukrainian Scientific Medical Youth Journal, Journal Year: 2025, Volume and Issue: 152(1)

Published: Feb. 25, 2025

cervical cancer is a tumor resulting from infection with high-risk human papillomavirus and develops precursors within the epithelium, which are now referred to as squamous intraepithelial lesions or neoplasias (SIL/CIN). CIN categorized into CIN1, CIN2, CIN3 depending on degree of epithelial involvement. The treatment patients pre-invasive relies determined histological classification. primary objective this study was thoroughly assess relevance immunohistochemical staining for biomarkers p16 Ki67 in evaluation (SIL). This research aimed elucidate relationship between levels expression these various stages neoplasia (CIN). By analyzing correlation severity lesions, seeks enhance understanding markers' diagnostic prognostic value clinical practices managing HPV-related pathology. Materials methods. We analyzed cases women suspected during cytology investigation. H&E-stained IHC slides all biopsy samples were reviewed classified according criteria outlined by LAST project. All processed routine procedures. Results. found, that divided three groups: negative, strong diffuse block-positive, focal patchy positive reaction. In histologically showed inconsistent positivity moderate intensity. glandular epithelium displayed clear signs atypia, revealed positivity. Ki-67 expressed cells nuclear basal parabasal layers stages. results significant differences among different groups CIN. P16 very helpful distinguishing CIN1 CIN2 CIN3. Conclusions. indicating consistent increase reflects progression. Utilizing both can help identify at higher risk Squamous Cell Carcinoma (SCC). applications have proven be important supplementary tools evaluating actual characteristics lesions. across grades underscore their usefulness validating diagnoses.

Language: Английский

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Immunohistochemical staining for cytology-based cervical cancer screening

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(3), P. 285 - 287

Published: May 1, 2024

Language: Английский

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New paradigms to break barriers in early cancer detection for improved prognosis and treatment outcomes

The Journal of Gene Medicine, Journal Year: 2024, Volume and Issue: 26(8)

Published: Aug. 1, 2024

The uncontrolled growth and spread of cancerous cells beyond their usual boundaries into surrounding tissues characterizes cancer. In developed countries, cancer is the leading cause death, while in underdeveloped nations, it ranks second. Using existing diagnostic tools has increased early detection rates, which crucial for effective treatment. recent decades, there been significant progress cancer-specific survival rates owing to advances ability accurately identify precursor lesions a aspect screening programs, as enables treatment initiation, lower long-term incidence invasive improved overall prognosis. However, these methods have limitations, such high costs technical challenges, can make accurate diagnosis certain deep-seated tumors difficult. To achieve prognosis, essential continue developing cutting-edge technologies molecular biology imaging.

Language: Английский

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Is it practical to add the p16/Ki67 immunohistochemical dual staining into liquid-based cytology for cervical cancer screening?

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2024, Volume and Issue: 63(3), P. 437 - 438

Published: May 1, 2024

Language: Английский

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