Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: July 15, 2024

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is known to infect people all ages and both sexes. Senior populations have greatest risk severe sexual dimorphism in clinical outcomes has been reported. Neurological symptoms are widely observed COVID-19 patients, with many survivors exhibiting persistent neurological cognitive impairment. The present study aims investigate impact age sex on neuroinflammatory response SARS-CoV-2 infection using a mouse model. Wild-type C57BL/6J mice were intranasally inoculated lineage B.1.351, variant mice. Older male exhibited significantly greater weight loss higher viral loads lung at 3 days post infection. Notably, no RNA was detected brains infected Nevertheless, expression IL-6, TNF-α, CCL-2 brain increased RNA-seq transcriptomic analysis showed that caused significant changes gene profiles, implicating innate immunity, defense virus, cerebrovascular neuronal functions. These findings demonstrate triggers response, despite lack detectable virus brain. Aberrant activation immune disruption blood-brain barrier endothelial cell integrity, suppression activity axonogenesis underlie Understanding role these affected pathways pathogenesis helps identify appropriate points therapeutic interventions alleviate dysfunction during COVID-19.

Language: Английский

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Cardiac symptoms in patients 3–6 months after contracting COVID-19– data from the polish STOP-COVID registry

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Abstract Background Common complaints of long COVID patients are cardiac symptoms such as fatigue, weakness, and a feeling palpitations. The study aimed to investigate the clinical features with persistent cardiological occurring within 3 6 months after COVID-19. Differences in ambulatory blood pressure monitoring (ABPM), Holter ECG (electrocardiogram) Echocardiography between people without were evaluated. We also assessed whether anxiety depression may be implicated outcomes. Materials methods This was retrospective affiliated STOP-COVID registry who attended follow-up visit 3–6 undergoing present performed tests: ABPM, Echocardiography. 504 additionally had GAD-2 (Generalized Anxiety Disorder 2-item) PHQ-2 (Patient Health Questionnaire-2) tests performed. Results analysis included 1080 patients. At least 1 analyzed 586 (54.3%). most common symptom fatigue (38.9%). Comparing or palpitations showed that mean value ventricular extrasystole higher former group ( p = 0.011). symptoms, there differences values 0.022) < 0.001) scales, well percentage responses related risk depression. Conclusion Cardiological among health issues must face contracting People more excessive extrasystoles than these symptoms. Trial registration Our based on medical data COVID-19 treated out-patient basis Polish Long-Covid Cardiovascular (PoLoCOV-CVD) (ClinicalTrials.gov identifier– NCT05018052, date 29.05.2020). Consent conduct obtained from Bioethics Committee District Medical Chamber Lodz (no. KB-0115/2021).

Language: Английский

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Lactoferrin Binds through Its N-Terminus to the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1021 - 1021

Published: Aug. 4, 2024

Since Coronavirus disease 2019 (COVID-19) still presents a considerable threat, it is beneficial to provide therapeutic supplements against it. In this respect, glycoprotein lactoferrin (LF) and lactoferricin (LFC), natural bioactive peptide yielded upon digestion from the N-terminus of LF, are utmost interest, since both have been shown reduce infections severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), virus responsible for COVID-19, in particular via blockade priming binding. Here, we, by means biochemical biophysical methods, reveal that LF directly binds S-protein SARS-CoV-2. We determined thermodynamic kinetic characteristics complex formation mapped mutual binding sites involved interaction, namely N-terminal region receptor-binding domain (RBD). These results may not only explain many observed protective effects LFC SARS-CoV-2 infection but also be instrumental proposing potent cost-effective supplemental tools management COVID-19.

Language: Английский

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Important Repercussions of the COVID-19 Pandemic Lifestyle Avoided by Researchers? Face Masks and Temporomandibular Disorders: A Systematic Search and Review

Published: May 20, 2024

Since December 2019, the COVID-19 virus has rapidly spread worldwide, prompting World Health Organization (WHO) to declare it a pandemic and advocate for widespread use of face masks mitigate transmission. In this review, we delve into potential impact prolonged mask on temporomandibular joint (TMJ) health, an area that garnered limited attention amidst research. Research revealed improper fit, constant readjustment can lead TMJ abnormalities. Similarly, there is demonstrated correlation between continuous usage increased incidence headaches, pain, diminished quality life. Many studies have highlighted discomfort in preauricular area, noises, headache, jaw muscle fatigue, as well dermatological disorders been attributed wear its TMJ. Our study catalyzes future research endeavors, urging deeper exploration implications long-term wear, not only context but also among occupational groups regularly exposed extended use. By unraveling complexities health evolving preventive measures, aim enhance our understanding safeguard well-being mask-wearers worldwide.

Language: Английский

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Could We Designate Long COVID a Syndrome?

Science Insights, Journal Year: 2024, Volume and Issue: 44(6), P. 1389 - 1391

Published: June 29, 2024

Long COVID has been subject to growing examination as researchers and healthcare professionals strive gain a deeper comprehension of its fundamental mechanisms consequences. While syndromes often consist group symptoms without distinct underlying cause, seems be more intricate. Studies indicate that it could affect several organ systems cause cellular-level harm, prompting specialists propose categorized syndrome rather than simple lingering consequences the virus. However, further study needs conducted for determining whether there are distinctive characteristics differentiate clinical entity from other post-viral conditions. Accurate identification will essential in guiding treatment approaches delivering appropriate therapy patients who suffer persistent after being infected with COVID-19.

Language: Английский

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Lights and Shadows of Long COVID: Are Latent Infections the Real Hidden Enemy?

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7124 - 7124

Published: Nov. 25, 2024

Long COVID-19 (LC) is a poorly understood, multifactorial condition that persists for at least three months following SARS-CoV-2 infection. The underlying pathophysiological mechanisms responsible the wide range of associated symptoms-including fatigue, brain fog, and respiratory issues-remain unclear. However, emerging evidence suggests reactivation latent viral infections, such as Epstein-Barr virus, cytomegalovirus, varicella-zoster may significantly contribute to complexity LC. These viruses can be reactivated by SARS-CoV-2, contributing chronic inflammatory state prolongs symptomatology. This review confirms potential involvement infections in LC examines whether these play an independent role or act synergistically with other factors. In addition, recent studies have highlighted persistence immune dysregulation key elements Our findings suggest preventative strategies, including vaccination antiviral treatments during acute phase COVID-19, show reducing risk preventing reactivation. tailored diagnostic therapeutic strategies targeting are urgently needed. Identifying biomarkers reactivation, particularly high-risk populations, could considered another effective strategy mitigate severity. Further research crucial better understand interactions between improve prevention treatment

Language: Английский

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The Correlation between Cardiac Magnetic Resonance Findings and Post-COVID-19: The Impact of Myocardial Injury on Quality of Life

Diagnostics, Journal Year: 2024, Volume and Issue: 14(17), P. 1937 - 1937

Published: Sept. 2, 2024

Background: In the post-COVID-19 era, there is growing concern regarding its impact on cardiovascular health and following effects overall quality of life affected individuals. This research seeks to investigate cardiac magnetic resonance (CMR) findings COVID-19 their Methods: An observational, cross-sectional study was conducted in consecutive patients with persistent symptoms after who were referred CMR due suspected myocardial injury. addition, completed a questionnaire about during period. Results: this study, 85 included. The population consisted mean age 42.5 ± 13.4 years, predominantly women, made up 69.4% population, while men 30.6%. showed non-ischemic injury 78.8% edema 14.1% patients. Late pericardial enhancement present 40% effusion 51.8% Pericardial (p = 0.001) more prevalent reported pronounced period compared acute infection phase. Predictors lower presence irregular heartbeat 0.039), problems that last longer than 12 weeks 0.018), 0.037). Conclusion: Acute myocarditis observed minority COVID-19, LGE pattern majority. Quality worse abnormalities, primarily effusion. Also, heartbeat, weeks, as well independent predictors

Language: Английский

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Potential Impacts of Prolonged Face Mask Use on Temporomandibular Joint Health as Neglected Lifestyle Repercussions of COVID-19 Pandemic—A Narrative Review

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1468 - 1468

Published: Sept. 8, 2024

Since December 2019, COVID-19 has rapidly spread worldwide, prompting the World Health Organization (WHO) to declare it a pandemic and advocate for widespread use of face masks mitigate transmission. In this review, we delve into potential impact prolonged mask on temporomandibular joint (TMJ) health, an area that garnered limited attention amidst research. Research revealed improper fit constant readjustment can lead TMJ abnormalities. Similarly, there is demonstrated correlation between continuous usage increased incidence headaches, pain, diminished quality life. Many studies have highlighted discomfort in preauricular area, noises, headache, jaw muscle fatigue, as well dermatological disorders, which been attributed wear its health. Our study catalyzes future research endeavors, urging deeper exploration implications long-term wear, not only context but also among occupational groups regularly exposed extended use. By unraveling complexities health evolving preventive measures, aim enhance our understanding issue safeguard well-being mask-wearers worldwide.

Language: Английский

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Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome?

European Archives of Psychiatry and Clinical Neuroscience, Journal Year: 2024, Volume and Issue: 274(8), P. 1797 - 1817

Published: Nov. 15, 2024

The SARS-CoV-2 pandemic has resulted in 762 million infections worldwide from 2020 to date, of which approximately ten percent are suffering the effects after infection 2019 (COVID-19) [1, 40]. In Germany, it is now assumed that at least one people suffer post-COVID condition with long-term consequences. These have been previously reported diseases like Myalgic Encephalomyelitis (ME) and Chronic Fatigue Syndrome (CFS). Symptoms show a changing variability recent surveys COVID context indicate 10-30 % outpatients, 50 70% hospitalised patients sequelae. Recent data suggest only 13% all ill were completely free symptoms recovery [3, 9]. Current hypotheses consider chronic inflammation, mitochondrial dysfunction, latent viral persistence, autoimmunity, changes human microbiome or multilocular sequelae various organ system infection. Hyperbaric oxygen therapy (HBOT) applied since 1957 for heart surgery, scuba dive accidents, CO intoxication, air embolisms anaerobic pathogens. Under hyperbaric pressure, physically dissolved blood higher concentrations reaches levels four times than under normobaric application. Moreover, alternation hyperoxia normoxia induces variety processes cellular level, improves supply areas locoregional hypoxia. Numerous target gene on new vessel formation, anti-inflammatory anti-oedematous demonstrated [74]. provision intermittently high, local increases repair regeneration normalises predominance hyperinflammation. At present time prospective, randomized placebo-controlled study exists positive global cognitive function, attention executive psychiatric pain interference. conclusion, up this date HBO scientifically proven treatment prospective controlled trial be effective improvement, brain network improvement cardiac function. HBOT may not theoretical but also potential impact targets current pathophysiology Post condition, warrants further scientific studies patients.

Language: Английский

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The Past and Future of Sleep Medicine

Sleep Medicine Clinics, Journal Year: 2024, Volume and Issue: 20(1), P. 1 - 17

Published: Dec. 9, 2024

Language: Английский

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