Oncologic Outcomes after Percutaneous Ablation for Colorectal Liver Metastases: An Updated Comprehensive Review DOI Creative Commons

David‐Dimitris Chlorogiannis,

Vlasios S. Sotirchos, Constantinos T. Sofocleous

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1536 - 1536

Published: Sept. 20, 2024

Colorectal cancer is a major cause of cancer-related mortality, with liver metastases occurring in over third patients, and correlated poor prognosis. Despite surgical resection being the primary treatment option, only about 20% patients qualify for surgery. Current guidelines recommend thermal ablation either alone or combined surgery to treat limited hepatic metastases, provided that all visible disease can be effectively eradicated. Several modalities, including radiofrequency ablation, microwave cryoablation, irreversible electroporation histotripsy, are part percutaneous armamentarium. Thermal radiofrequency, offer local tumor control rates comparable selected tumors ablated margins. This review aims encapsulate current clinical evidence regarding efficacy oncologic outcomes after colorectal metastatic disease.

Language: Английский

Prognostic Comparison of Complete vs. Incomplete Radiofrequency Ablation for Colorectal Liver Metastases: A Multicenter Prospective Study DOI Creative Commons

Huilin Lu,

Xuancheng Xie,

Yulan Zeng

et al.

Cancer Medicine, Journal Year: 2025, Volume and Issue: 14(8)

Published: April 1, 2025

ABSTRACT Background Radiofrequency ablation (RFA) is a curative treatment for colorectal liver metastases (CLMs) in selected patients. NCCN guidelines recommend RFA both unresectable and select resectable CLMs when complete with adequate margins feasible. While can achieve oncologic outcomes comparable to surgery well‐selected patients, residual tumors are associated poorer prognosis. Objectives To identify predictors of tumor after percutaneous evaluate their impact on overall survival (OS) new intrahepatic (NIHM). Methods We prospectively included patients who underwent from November 2019 2022. Dynamic contrast‐enhanced computed tomography assessed before RFA. Residual was defined as active visible immediately post‐ablation or within 4–8 weeks, 1 cm the zone. Data three centers formed developmental cohort, validated fourth center. Cox regression Kaplan–Meier analysis local progression‐free (LTPFS), NIHM, OS. Results Among 200 (mean age 61 years, 126 men) 410 tumors, independent perivascular location (odds ratio [OR] = 6.673), size ≥ 20 mm (OR 3.925), minimal ablative margin 0.599). These factors also predicted LTPFS. NIHM more frequent group than (cRFA) ( p 0.002). Median OS 45 months, shorter (30 vs. 48 0.009). Patients received transarterial chemoembolization combined hepatic arterial infusion chemotherapy had median 43 compared 34 months alone 0.039). Conclusions A non‐perivascular location, < mm, sufficient essential achieving increased

Language: Английский

Citations

0
PET/CT-guided Tumor Ablation DOI

David‐Dimitris Chlorogiannis,

Constantinos T. Sofocleous, Liwei Jiang

et al.

PET Clinics, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Evaluation of the Ki-67 labeling index on immediate pre-ablation biopsies as a predictive biomarker of local recurrence of colorectal cancer liver metastases DOI
Vlasios S. Sotirchos, Efsevia Vakiani, Carlie Sigel

et al.

Cytotechnology, Journal Year: 2024, Volume and Issue: 77(1)

Published: Dec. 30, 2024

Language: Английский

Citations

1
Oncologic Outcomes after Percutaneous Ablation for Colorectal Liver Metastases: An Updated Comprehensive Review DOI Creative Commons

David‐Dimitris Chlorogiannis,

Vlasios S. Sotirchos, Constantinos T. Sofocleous

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1536 - 1536

Published: Sept. 20, 2024

Colorectal cancer is a major cause of cancer-related mortality, with liver metastases occurring in over third patients, and correlated poor prognosis. Despite surgical resection being the primary treatment option, only about 20% patients qualify for surgery. Current guidelines recommend thermal ablation either alone or combined surgery to treat limited hepatic metastases, provided that all visible disease can be effectively eradicated. Several modalities, including radiofrequency ablation, microwave cryoablation, irreversible electroporation histotripsy, are part percutaneous armamentarium. Thermal radiofrequency, offer local tumor control rates comparable selected tumors ablated margins. This review aims encapsulate current clinical evidence regarding efficacy oncologic outcomes after colorectal metastatic disease.

Language: Английский

Citations

0