Sudden cardiac death, altitude & physical activity: A retrospective analysis from the highest Italian region (Aosta valley)

Legal Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 102608 - 102608

Published: March 1, 2025

Language: Английский

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VEGF Polymorphisms (VEGF-936 C/T, VEGF-634 G/C and VEGF-2578 C/A) and Cardiovascular Implications in Long COVID Patients

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8667 - 8667

Published: Aug. 8, 2024

The COVID-19 pandemic has raised awareness of the virus’s long-term non-pulmonary consequences. This study examined relationship between genetic polymorphisms VEGF and cardiac dysfunction subclinical atherosclerosis in patients recovering from COVID-19. included 67 previously diagnosed with VEGF-936C/T, VEGF-634G/C, VEGF-2578C/A statuses were determined. Conventional echocardiography arterial parameters assessments performed at inclusion six months after first assessment. For dominant over-dominant models showed a significant increase ejection fraction COVID (p = 0.044 0.048) was also predictive independent factor for augmentation index (β 3.07; p 0.024). model rise RV-RA gradient (3.702 mmHg) 0.028 95% CI: 0.040–7.363), indicating greater difference (4.254 0.025 0.624–7.884). findings VEGF-634G/C not statistically significant, except TAPSE during initial evaluation, using codominant model. VEGF-2578C/A, ventricular filling pressure (E/E’ratio) best described under recessive Our research suggests that VEG-936C/T genotype may impact baseline level subsequent changes function atherosclerosis. These offer valuable insights into complex correlation cardiovascular disfunction long patients.

Language: Английский

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Epithelial Antimicrobial Peptide/Protein and Cytokine Expression Profiles Obtained from Nasopharyngeal Swabs of SARS-CoV-2-Infected and Non-Infected Subjects

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1471 - 1471

Published: Sept. 15, 2024

Immune responses of the epithelia upper respiratory tract are likely crucial in early inhibition viral replication and finally clearance SARS-CoV-2. We aimed to compare expression profiles antimicrobial peptides/proteins (AMPs) related cytokines observed nasopharynx SARS-CoV-2-infected patients non-infected controls assess associations between these parameters COVID-19 patients’ outcomes. included 45 subjects who had tested positive for SARS-CoV-2 22 control negative Biomaterial detection, as well gene protein studies, was obtained from all using nasopharyngeal swabs which were performed a maximum 7 days before inclusion study. Univariable multivariable statistics performed. When compared controls, mRNA levels human β-defensin 1 (hBD-1), LL-37, trappin-2 significantly higher specimens patients. Protein hBD-1 also increased group. interferon-ɣ (IFN-ɣ), tumor necrosis factor- ɑ (TNF-ɑ), interleukin-6 (IL-6) measured than those could be confirmed IFN-ɣ IL-6. A significant correlation only analysis revealed that low associated with severe/fatal The occurrence pneumonia lower IL-6 mRNA, TNF-ɑ mRNA. Concerning outcomes, logistic regression model none aforementioned remained model. However, independent predictor absence [odds ratio: 0.35 (95% CI 0.14 0.88, p = 0.024)]. In conclusion, AMPs (hBD-1, trappin-2) (IL-6, IFN-ɣ, TNF-ɑ) is upregulated response infection, indicating play role local host defense against virus. Upregulated during phase infection pneumonia. Hence, high appears protective factor lung complications

Language: Английский

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Impact of the Coronavirus Disease 2019 [COVID-19] Pandemic on Post-Acute Care of Patients with Heart Failure and the Effectiveness of Vaccine Prevention

Healthcare, Journal Year: 2024, Volume and Issue: 12(21), P. 2171 - 2171

Published: Oct. 31, 2024

The Heart Failure Post-Acute Care [HF-PAC] program is a specialized healthcare aimed at providing comprehensive care and support for patients with heart failure [HF] as they transition from acute hospital settings to home. But the impact of coronavirus disease 2019 [COVID-19] pandemic on HF-PAC remains unknown. Furthermore, effects COVID-19 vaccination these warrants further investigation.

Language: Английский

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