Prevalence of HPV infection in the general population of young and adult males in Italy DOI Creative Commons
Giuseppe Grande, Andrea Graziani, Luca De Toni

et al.

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Background The most prevalent sexually transmitted disease in the world has human papillomavirus (HPV) as its etiological agent. Objectives To evaluate prevalence of previous and actual HPV infection clinical manifestations unselected males. Materials Methods A total 718 males participating to a surveillance program were asked complete study visit at our unit, including semen collection, balanopreputial sulcus swab, blood collection for anti‐HPV immunoglobulin G (IgG). When HPV‐DNA was detected, we performed fluorescence situ hybridization, oral anal penoscopy. Because studies demonstrated very high risk subjects with history HPV‐induced lesions, partner diagnosed or reporting couple infertility sexual promiscuity an increase having sex males, unprotected intercourses heavy smokers, patients therefore stratified according presence these known factors (RFs). Results Actual detected 401/718 (55.85%). Oral reported 80 52 subjects. Anti‐HPV IgG antibodies have been 288 overall exposition, considering and/or 77.99%. Among infected men, high‐risk genotypes 66.08%. 514 considered RF population, while 150 classified non‐RF population. There significantly higher condylomatosis (odds ratio [OR] 4.07) seminal (OR 6.22) group. Discussion Conclusion These data represent alert healthcare system perform informative screening campaigns promote vaccination both young people adult infections.

Language: Английский

E5 Oncoprotein: A Key Player in Human Papillomavirus-Positive Head and Neck Cancer Pathogenesis and Therapy Resistance DOI Creative Commons
Vanessa Emanuelle Pereira Santos, Bianca de França São Marcos, Pedro Henrique Bezerra Fontes

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(4), P. 512 - 512

Published: April 1, 2025

Head and neck cancer (HNC) is the sixth most prevalent type of worldwide associated with low five-year survival rates. Alcoholism smoking are main risk factors development head (HNC). However, Human Papillomavirus (HPV) infection has been reported as a significant factor, particularly for oropharyngeal subset. In these cases, patients HPV-positive HNC exhibit better clinical prognosis; however, resistance to chemotherapy frequently reported. The carcinogenic activity HPV related viral oncoproteins E5, E6, E7. E5 immune evasion mechanisms modulation tumor microenvironment, which appears be linked virus’s chemotherapeutic treatments. Here, we review potential in targeted therapy discuss relevant data regarding this oncoprotein carcinogenesis.

Language: Английский

Citations

0
Prevalence of HPV infection in the general population of young and adult males in Italy DOI Creative Commons
Giuseppe Grande, Andrea Graziani, Luca De Toni

et al.

Andrology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 3, 2024

Abstract Background The most prevalent sexually transmitted disease in the world has human papillomavirus (HPV) as its etiological agent. Objectives To evaluate prevalence of previous and actual HPV infection clinical manifestations unselected males. Materials Methods A total 718 males participating to a surveillance program were asked complete study visit at our unit, including semen collection, balanopreputial sulcus swab, blood collection for anti‐HPV immunoglobulin G (IgG). When HPV‐DNA was detected, we performed fluorescence situ hybridization, oral anal penoscopy. Because studies demonstrated very high risk subjects with history HPV‐induced lesions, partner diagnosed or reporting couple infertility sexual promiscuity an increase having sex males, unprotected intercourses heavy smokers, patients therefore stratified according presence these known factors (RFs). Results Actual detected 401/718 (55.85%). Oral reported 80 52 subjects. Anti‐HPV IgG antibodies have been 288 overall exposition, considering and/or 77.99%. Among infected men, high‐risk genotypes 66.08%. 514 considered RF population, while 150 classified non‐RF population. There significantly higher condylomatosis (odds ratio [OR] 4.07) seminal (OR 6.22) group. Discussion Conclusion These data represent alert healthcare system perform informative screening campaigns promote vaccination both young people adult infections.

Language: Английский

Citations

0