Biomarker Insights: Evaluation of Presepsin, Apelin, and Irisin Levels in Cutaneous Leishmaniasis DOI Creative Commons
Revşa Evin Canpolat Erkan, Recep Tekin, Bilal Sula

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2869 - 2869

Published: Dec. 20, 2024

Background/Objectives: Cutaneous leishmaniasis (CL) is a skin disease caused by Leishmania parasites. Presepsin, irisin, and apelin are biomarkers that involved in the inflammatory response. The aim of this study was to investigate association between serum levels specific biomarkers, such as presepsin, apelin, clinical features, location, number, size lesions patients with CL. Methods: This single-centre, prospective cohort involving total 30 compatible CL healthy matched controls. Age, sex, type lesion, location number lesions, diameter were recorded. measured blood samples patient group analysed comparison those control group. Results: findings revealed presepsin significantly elevated compared controls (p = 0.000). However, no statistically significant differences observed groups for irisin (p-values 0.096 0.836, respectively). A negative correlation identified largest Conclusions: It appears measuring may be beneficial. Presepsin has potential serve prognostic marker CL, offering benefits guiding clinicians assessing progression response treatment.

Language: Английский

Current Diagnosis and Treatment of Small Bowel Obstruction: Imaging Diagnosis, Serum Biomarkers, and Treatment Strategies DOI

丞俊 蔡

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 97 - 106

Published: Jan. 1, 2025

Language: Английский

Citations

0
The potential role of leukocytes cell population data (CPD) for diagnosing sepsis in adult patients admitted to the intensive care unit DOI
Vincenzo Roccaforte,

Giovanni Sabbatini,

Rossella Panella

et al.

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Abstract Objectives The aim of the study was to evaluate predictive value cell population data (CPD) parameters in comparison with procalcitonin (PCT) and C-reactive protein (CRP) for an early diagnosis sepsis intensive care unit (ICU). effect renal function on CPD, PCT CRP, septic non-septic patients also investigated. Methods This is a retrospective, observational single-center study, performed collected from consecutively admitted ICU Edoardo Bassini Hospital Milan. Patients were divided according Sepsis-III criteria. control group formed by critically ill without sepsis. further shock. Results A significant difference between found neutrophils complexity (NE-SSC), fluorescence intensity (NE-SFL), width dispersion (NE-WY), monocytes (MO-X), (MO-Y), CRP parameters. PCT, sixe (NE-FSC), NE-WY, size (NE-WZ) MO-X discriminated septic-shock patients. CPD not influenced function. had heterogeneous diagnostic performance efficiency prediction Overall, NE-SSC, NE-SFL, (NE-WX), MO-X, MO-Y, displayed best Conclusions suggested that some (i.e., NE-SFL MO-X) might provide useful information management

Language: Английский

Citations

0
The value of midregional proadrenomedullin to predict mortality in intensive care units DOI Creative Commons

Luisa Agnello,

Fabio Del Ben, Andrea Cortegiani

et al.

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: 570, P. 120212 - 120212

Published: Feb. 22, 2025

This study evaluates the value of midregional proadrenomedullin (mr-proADM), C-reactive protein (CRP), procalcitonin (PCT), and presepsin (PSP) in predicting mortality, considering both their absolute values at different time points dynamic kinetics. We conducted a retrospective observational including all consecutive adult ICU admissions. Biomarkers were measured admission (T0), day 3 (T3), 5 (T5). assessed values, relative variations, categorized changes (≥50 % increase or decrease). A total 99 patients included. mr-proADM T3 had highest predictive for mortality (AUC = 0.77), followed by PSP 0.70). Cox regression identified as an independent predictor (HR: 1.16, p < 0.001), with ≥ 50 from T0 to significantly associated risk 4.15, 0.001). In low baseline levels, was 4.43, 0.04), while those high more predictive. Our findings suggest that is most informative biomarker its providing valuable prognostic insights. Importantly, stratified analysis highlights stratification approaches may be necessary based on levels.

Language: Английский

Citations

0
Globotriaosylceramide as a potential biomarker for auxiliary detection of lower respiratory tract infections of Pseudomonas aeruginosa DOI Open Access
Tao Xu, Jiawei Li, Yuqing Dong

et al.

Experimental and Therapeutic Medicine, Journal Year: 2025, Volume and Issue: 29(4), P. 1 - 9

Published: Feb. 24, 2025

Lower respiratory tract infections (LRTIs) caused by Pseudomonas aeruginosa (PA) are a significant health concern, notably among vulnerable populations. The glycosphingolipid receptor globotriaosylceramide (Gb3) has been implicated in PA pathogenicity, however, its clinical implications remain underexplored. present study aimed to investigate the value of Gb3 concentrations serum and bronchoalveolar lavage fluid (BALF) as biomarker for PA-induced LRTIs. In current prospective study, 54 PA-infected patients healthy individuals were enrolled controls. levels measured using ELISA kit inflammatory markers assessed. diagnostic accuracy was evaluated receiver operating characteristic (ROC) curve analysis. with LRTIs exhibited significantly higher concentration both BALF compared those noted controls, more pronounced elevations BALF. area under ROC 0.899 0.812 Gb3, indicating high sensitivity specificity diagnosis infection. also found be correlated C-reactive protein procalcitonin levels, suggesting potential reflecting infection severity. Overall, findings revealed association between LRTIs, proposing promising early detection diagnosis. Further research is warranted validate role various patient populations explore dynamics over course

Language: Английский

Citations

0
Combining PCT with CRP is better than separate testing for patients with bacteriuria in the intensive care unit: a retrospective study DOI Creative Commons

Guoming Zhang,

Xu-Xiao Guo

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Aug. 29, 2024

Previous studies on PCT for urinary tract infections (UTI) have focused primarily minors. This study investigated the predictive value of neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) level and procalcitonin (PCT) in adult patients with bacteriuria IUC.

Language: Английский

Citations

2
Biomarker Insights: Evaluation of Presepsin, Apelin, and Irisin Levels in Cutaneous Leishmaniasis DOI Creative Commons
Revşa Evin Canpolat Erkan, Recep Tekin, Bilal Sula

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2869 - 2869

Published: Dec. 20, 2024

Background/Objectives: Cutaneous leishmaniasis (CL) is a skin disease caused by Leishmania parasites. Presepsin, irisin, and apelin are biomarkers that involved in the inflammatory response. The aim of this study was to investigate association between serum levels specific biomarkers, such as presepsin, apelin, clinical features, location, number, size lesions patients with CL. Methods: This single-centre, prospective cohort involving total 30 compatible CL healthy matched controls. Age, sex, type lesion, location number lesions, diameter were recorded. measured blood samples patient group analysed comparison those control group. Results: findings revealed presepsin significantly elevated compared controls (p = 0.000). However, no statistically significant differences observed groups for irisin (p-values 0.096 0.836, respectively). A negative correlation identified largest Conclusions: It appears measuring may be beneficial. Presepsin has potential serve prognostic marker CL, offering benefits guiding clinicians assessing progression response treatment.

Language: Английский

Citations

0