Usefulness of Atherogenic Indices for Predicting High Values of Avoidable Lost Life Years Heart Age in 139,634 Spanish Workers DOI Creative Commons
Tomás Sastre-Alzamora, Pedro Juan Tárraga López, Ángel Arturo López‐González

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2388 - 2388

Published: Oct. 26, 2024

Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, accounting for one-third all global deaths. The World Health Organization (WHO) asserts that prevention is most effective strategy to combat CVD, emphasizing need non-invasive, low-cost tools identify individuals at high risk CVD. Atherogenic indices heart age (HA) valuable assessing cardiovascular (CVR). aim our study was evaluate association between atherogenic HA. Methods: A cross-sectional conducted involving 139,634 Spanish workers determine three ROC curves were employed cut-off values various used estimate points, along with their sensitivity, specificity, Youden index, determined, area under curve (AUC) calculated. Results: As increased, so did having elevated avoidable lost life years (ALLY) In analysis, AUC best results corresponded total cholesterol/HDL-c an 0.803 in females 0.790 males. LDL-c/HDL-c index showed 0.780 women 0.750 men, around 0.4. When analyzing triglycerides/HDL-c, 0.760 0.746 men. Conclusions: HA show a close relationship, increase these rise values. Raising patient awareness as CVR levels increase, does may be useful achieving some benefit reducing CVR.

Language: Английский

Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography DOI Creative Commons
Taha Okan, Cihan Altın, Caner Topaloğlu

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 206 - 206

Published: Jan. 17, 2025

Background/Objectives: As an endocrine organ, adipose tissue produces adipokines that influence coronary artery disease (CAD). The objective of this study was to assess the potential value CTRP5 and chemerin in differentiating computed tomography angiography (CCTA)-confirmed (CAD) versus non-CAD. Secondarily, within CCTA-confirmed CAD group, aim investigate relationship between severity extent CAD, as determined by calcium score (CACS), levels chemerin. Methods: Consecutive individuals with chest pain underwent CCTA evaluate anatomy were divided into two groups. group included patients any atherosclerotic plaque (soft, mixed, or calcified) regardless calcification, while non-CAD consisted without plaques on CCTA, zero CACS, ischemia stress ECG. evaluated using CACS. Blood samples collected stored at -80 °C for analysis via ELISA. Results: Serum significantly higher compared (221.83 ± 103.81 vs. 149.35 50.99 ng/mL, p = 0.003 105.02 35.62 86.07 19.47 0.005, respectively). Receiver operating characteristic (ROC) showed a cutoff 172.30 ng/mL had 70% sensitivity 73% specificity identifying 90.46 61% 62% specificity. A strong positive correlation observed chemerin, but neither adipokine Agatston score, measure extent, nor stenosis CCTA. Conclusions: elevated showing greater However, linked differing from findings based invasive (ICA). may serve promising "all-or-none biomarker" presence.

Language: Английский

Citations

0
Association between the atherogenic index of plasma and long-term risk of type 2 diabetes: a 12-year cohort study based on the Japanese population DOI Creative Commons
Qianxing Zhou,

Yamei Wu,

Mingkang Li

et al.

Cardiovascular Diabetology, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 30, 2025

Atherosclerotic dyslipidemia is associated with an increased risk of type 2 diabetes (T2D). Although previous studies have demonstrated association between the atherogenic index plasma (AIP) and insulin resistance, there remains a scarcity large cohort investigating AIP long-term T2D in general population. This study aims to investigate potential individuals normal fasting glucose levels. retrospective included 15,453 participants. The was calculated using formula log [triglyceride (mmol/L)/high-density lipoprotein cholesterol (mmol/L)]. Cox proportional hazard regression models were employed assess risk. nonlinear examined restricted cubic spline (RCS) model. During average follow-up period 6.05 years, 373 participants developed T2D. After adjusting for confounding factors, elevated independently developing (HR 1.763, 95%CI 1.210–2.568, P = 0.003). RCS analysis revealed J-shaped risk, sharp increase when levels exceeded − 0.268. Moreover, time-dependent receiver operating characteristic consistently moderate predictability new-onset within 1 12 years. exhibits Therefore, maintaining below certain threshold (-0.268) might help prevent onset

Language: Английский

Citations

0
Cardiovascular risk patterns through AI-enhanced clustering of longitudinal health data DOI
Maryam Mahdavi, Anoshirvan Kazemnejad, Abbas Asosheh

et al.

Journal of Diabetes & Metabolic Disorders, Journal Year: 2025, Volume and Issue: 24(1)

Published: March 15, 2025

Language: Английский

Citations

0
Research Progress of Atherogenic Index of Plasma in Premature Coronary Heart Disease DOI

迎丽 魏

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 369 - 377

Published: Jan. 1, 2025

Language: Английский

Citations

0
Usefulness of Atherogenic Indices for Predicting High Values of Avoidable Lost Life Years Heart Age in 139,634 Spanish Workers DOI Creative Commons
Tomás Sastre-Alzamora, Pedro Juan Tárraga López, Ángel Arturo López‐González

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2388 - 2388

Published: Oct. 26, 2024

Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide, accounting for one-third all global deaths. The World Health Organization (WHO) asserts that prevention is most effective strategy to combat CVD, emphasizing need non-invasive, low-cost tools identify individuals at high risk CVD. Atherogenic indices heart age (HA) valuable assessing cardiovascular (CVR). aim our study was evaluate association between atherogenic HA. Methods: A cross-sectional conducted involving 139,634 Spanish workers determine three ROC curves were employed cut-off values various used estimate points, along with their sensitivity, specificity, Youden index, determined, area under curve (AUC) calculated. Results: As increased, so did having elevated avoidable lost life years (ALLY) In analysis, AUC best results corresponded total cholesterol/HDL-c an 0.803 in females 0.790 males. LDL-c/HDL-c index showed 0.780 women 0.750 men, around 0.4. When analyzing triglycerides/HDL-c, 0.760 0.746 men. Conclusions: HA show a close relationship, increase these rise values. Raising patient awareness as CVR levels increase, does may be useful achieving some benefit reducing CVR.

Language: Английский

Citations

0