Tumor innervation in cervical cancer: More is worse DOI Creative Commons
G. Chen, Qingqing Ji, Ruihua He

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Background: The nervous system plays a significant role in tumor growth and metastasis. However, the low frequencies of perineural invasion reported previous studies on human cervical cancer — ranging from 7.0% to 35.1% cases may overlook active that nerves play progression. Neurosecretory factors can promote migration invasion, even classified as “PNI-negative”. Therefore, this study aims clarify whether innervation influences progression patient outcomes. Methods: We evaluated gene signatures myelinating Schwann cells using IPAS scoring predict degree 304 patients TCGA database. Subsequently, we constructed myelin-associated risk prognostic signature by LASSO regression analysis. Finally, obtained score quantitative formula divided all samples into high- low- groups. Results: Our results indicated was associated with poor survival. Higher levels correlated an impaired immune response reduced expression checkpoints, including PD-1. model demonstrated excellent consistency between predictions actual survival Conclusions: Tumor crucial regulation prognosis cancer, identified offer valuable tool for stratification prediction clinical practice.

Language: Английский

Genetic Variants of Interleukin-8 and Interleukin-16 and Their Association with Cervical Cancer Risk DOI Creative Commons
Rafał Watrowski,

Eva Schuster,

Stephan Polterauer

et al.

Life, Journal Year: 2025, Volume and Issue: 15(2), P. 135 - 135

Published: Jan. 21, 2025

Background: Cervical cancer (CC) is the fourth most common diagnosis in women worldwide. Infection with high-risk human papillomavirus (HPV) a critical but not determinative condition for CC development, as several co-factors modulate progression of HPV-associated cervical lesions. Interleukin-8 (IL-8) and Interleukin-16 (IL-16) are chemokine-like interleukins involved pathogenesis various cancers. Singular studies Asian populations have suggested potential role IL-8 rs4073 (−251 A>T) IL-16 rs1131445 (3′UTR T>C) carcinogenesis. Methods: A case-control study was conducted European cohort 339 women, including 126 patients 213 controls. Four SNPs, A>T), rs2227306 (+781 C>T), rs1126647 (+2767 rs2227543 (+1633 four polymorphism, rs4778889 (−295 T>C), rs11556218 (3441 T>G), rs4072111 (1300 were assessed using RFLP-PCR analyzed under seven inheritance models. Subgroup analyses stratified by menopausal status (age threshold 51 years), disease stage, histological subtype. Results: significantly associated an increased risk premenopausal co-dominant (p = 0.038), dominant 0.022), heterozygote 0.045) models, identifying T allele (OR 2.31, CI95% 1.17–4.56; p 0.017). In aged over 51, 0.048) overdominant 0.042) models model 0.092). None SNPs entire cohort. Specifically, neither nor rs4073, previously reported factors populations, this Conclusions: These findings highlight age stage immunity susceptibility, suggest that may function differently carcinogenesis compared other cancers, emphasize importance ethnic background risk, warranting further research.

Language: Английский

Citations

0
Tumor innervation in cervical cancer: Prognostic insights from myelin‐associated risk signatures DOI Creative Commons
G. Chen,

Zhen Zheng,

Qingqing Ji

et al.

FASEB BioAdvances, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

The reported frequencies of perineural invasion (PNI) in human cervical cancer, ranging from 7.0% to 35.1%, may underestimate the significant role that nerves play cancer progression. Neurosecretory factors can promote tumor migration and invasion, even cases classified as "PNI-negative". This study aimed clarify whether innervation influences progression patient outcomes. We first evaluated gene signatures myelinating Schwann cells (SCs) using Inferring Pathway Activity Suppression (IPAS) scoring system predict degree 304 patients Cancer Genome Atlas (TCGA) database. Subsequently, we constructed a myelin-associated risk prognostic signature LASSO regression analysis. Finally, obtained score quantitative formula categorized all samples into high- low-risk groups. Our results indicated is associated with poor survival. Higher levels were correlated an impaired immune response reduced expression checkpoints, including PD-L1. model demonstrated excellent consistency between predicted actual survival Overall, plays crucial regulating prognosis. identified offer valuable tool for stratification prediction clinical practice.

Language: Английский

Citations

0
Fgf17: A regulator of the mid/hind brain boundary in mammals DOI Creative Commons

Zane Oberholzer,

Chiron Loubser,

Natalya Nikitina

et al.

Differentiation, Journal Year: 2024, Volume and Issue: 140, P. 100813 - 100813

Published: Sept. 16, 2024

Language: Английский

Citations

0
Tumor innervation in cervical cancer: More is worse DOI Creative Commons
G. Chen, Qingqing Ji, Ruihua He

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Background: The nervous system plays a significant role in tumor growth and metastasis. However, the low frequencies of perineural invasion reported previous studies on human cervical cancer — ranging from 7.0% to 35.1% cases may overlook active that nerves play progression. Neurosecretory factors can promote migration invasion, even classified as “PNI-negative”. Therefore, this study aims clarify whether innervation influences progression patient outcomes. Methods: We evaluated gene signatures myelinating Schwann cells using IPAS scoring predict degree 304 patients TCGA database. Subsequently, we constructed myelin-associated risk prognostic signature by LASSO regression analysis. Finally, obtained score quantitative formula divided all samples into high- low- groups. Results: Our results indicated was associated with poor survival. Higher levels correlated an impaired immune response reduced expression checkpoints, including PD-1. model demonstrated excellent consistency between predictions actual survival Conclusions: Tumor crucial regulation prognosis cancer, identified offer valuable tool for stratification prediction clinical practice.

Language: Английский

Citations

0