Multimodal Intravascular Imaging of the Vulnerable Coronary Plaque DOI
Andrea Milzi, Antonio Landi,

Rosalia Dettori

et al.

Echocardiography, Journal Year: 2024, Volume and Issue: 41(12)

Published: Nov. 1, 2024

ABSTRACT Vulnerable coronary plaques are atherosclerotic lesions which, due to their specific phenotype, prone plaque rupture and cause acute syndromes, with subsequent relevant morbidity mortality. Strategies break the chain link between vulnerability adverse clinical events include optimized pharmacologic prevention potentially also preemptive percutaneous interventions (previously defined as “plaque sealing” or passivation”). Various morphologic features of vulnerable have been described, including aspects regarding large necrotic lipid content, thin fibrous cap, presence extent calcifications small size calcification angle, well macrophage infiltration within plaque. The detection these is possible intravascular imaging modalities such ultrasound (IVUS), near‐infrared spectroscopy (NIRS), optical coherence tomography (OCT). This review explores peculiarities three for features.

Language: Английский

Computed Tomography Angiography in the Catheterization Laboratory: A Guide Towards Optimizing Coronary Interventions DOI Creative Commons
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris

et al.

Journal of Cardiovascular Development and Disease, Journal Year: 2025, Volume and Issue: 12(1), P. 28 - 28

Published: Jan. 16, 2025

Cardiac computed tomography (CT) has become an essential tool in the pre-procedural planning and optimization of coronary interventions. Its non-invasive nature allows for detailed visualization anatomy, including plaque burden, vessel morphology, presence stenosis, aiding precise decision making revascularization strategies. Clinicians can assess not only extent artery disease but also functional significance lesions using techniques like fractional flow reserve (FFR-CT). By providing comprehensive insights into structure hemodynamics, cardiac CT helps guide personalized treatment plans, ensuring more accurate selection patients percutaneous interventions or bypass grafting potentially improving patient outcomes.

Language: Английский

Citations

0
Diagnostic Potential of CTRP5 and Chemerin for Coronary Artery Disease: A Study by Coronary Computed Tomography Angiography DOI Creative Commons
Taha Okan, Cihan Altın, Caner Topaloğlu

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 206 - 206

Published: Jan. 17, 2025

Background/Objectives: As an endocrine organ, adipose tissue produces adipokines that influence coronary artery disease (CAD). The objective of this study was to assess the potential value CTRP5 and chemerin in differentiating computed tomography angiography (CCTA)-confirmed (CAD) versus non-CAD. Secondarily, within CCTA-confirmed CAD group, aim investigate relationship between severity extent CAD, as determined by calcium score (CACS), levels chemerin. Methods: Consecutive individuals with chest pain underwent CCTA evaluate anatomy were divided into two groups. group included patients any atherosclerotic plaque (soft, mixed, or calcified) regardless calcification, while non-CAD consisted without plaques on CCTA, zero CACS, ischemia stress ECG. evaluated using CACS. Blood samples collected stored at -80 °C for analysis via ELISA. Results: Serum significantly higher compared (221.83 ± 103.81 vs. 149.35 50.99 ng/mL, p = 0.003 105.02 35.62 86.07 19.47 0.005, respectively). Receiver operating characteristic (ROC) showed a cutoff 172.30 ng/mL had 70% sensitivity 73% specificity identifying 90.46 61% 62% specificity. A strong positive correlation observed chemerin, but neither adipokine Agatston score, measure extent, nor stenosis CCTA. Conclusions: elevated showing greater However, linked differing from findings based invasive (ICA). may serve promising "all-or-none biomarker" presence.

Language: Английский

Citations

0
Diagnostic Accuracy of Computed Tomography (CT) Coronary Angiography Compared to Invasive Coronary Angiography for Detecting Coronary Artery Disease: A Systematic Review DOI Open Access
M. Salman Khan, Muhammad Anees,

Ahmad Khan

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Coronary artery disease (CAD) is a significant cause of morbidity and mortality worldwide, the prevalence continually rising. Invasive coronary angiography (ICA) has been considered gold standard in CAD diagnosis as it offers precise information about presence severity blockages. However, computed tomography (CTCA) emerged preferred noninvasive imaging technique from viewpoint patient risk because provides high-resolution images. This systematic review aims to compare diagnostic accuracy CTCA with ICA diagnose among patients. literature involved database search PubMed, Medline, Cochrane Library for articles 2014 2024. After screening 650 records, removing duplicates, assessing 63 reports eligibility, five studies were included final analysis. Diagnostic parameters like sensitivity, specificity, positive predictive value (PPV), negative (NPV) calculated. The study found that demonstrated high very sensitivity specificity detecting CAD. It minimizes number such procedures related consequences; other trials showed decrease myocardial infarctions over an extended period. appears reliable alternative ICA, proving equally effective low- intermediate-risk patients but less high-risk cases, where remains necessary. innovative, invasive solution moderate-risk patients, consistent patient-directed care. due emphasis on its relative strengths, relevant even today individuals, especially those requiring most urgent intervention. More recent developments large-scale investigations are essential optimize use clinical practice clarify role treatment.

Language: Английский

Citations

0
Advancements in Coronary CT Angiography: Innovations in Diagnosis, Risk Stratification, and Prognosis in Atherosclerosis DOI

Kyvan Irannejad,

Srikanth Krishnan,

Beshoy Iskander

et al.

Current Treatment Options in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 14, 2025

Language: Английский

Citations

0
Multimodal Intravascular Imaging of the Vulnerable Coronary Plaque DOI
Andrea Milzi, Antonio Landi,

Rosalia Dettori

et al.

Echocardiography, Journal Year: 2024, Volume and Issue: 41(12)

Published: Nov. 1, 2024

ABSTRACT Vulnerable coronary plaques are atherosclerotic lesions which, due to their specific phenotype, prone plaque rupture and cause acute syndromes, with subsequent relevant morbidity mortality. Strategies break the chain link between vulnerability adverse clinical events include optimized pharmacologic prevention potentially also preemptive percutaneous interventions (previously defined as “plaque sealing” or passivation”). Various morphologic features of vulnerable have been described, including aspects regarding large necrotic lipid content, thin fibrous cap, presence extent calcifications small size calcification angle, well macrophage infiltration within plaque. The detection these is possible intravascular imaging modalities such ultrasound (IVUS), near‐infrared spectroscopy (NIRS), optical coherence tomography (OCT). This review explores peculiarities three for features.

Language: Английский

Citations

2