The role of the advanced lung cancer inflammation index (ALI) in the risk of liver fibrosis and mortality among US adult MAFLD patients: a cross-sectional study of NHANES 1999–2018 DOI Creative Commons

Chunchun Yu,

L. Chen,

Wanting Hu

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 20, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic globally, with inflammation and nutrition playing key roles in its progression. The Advanced Lung Cancer Inflammation Index (ALI) novel biomarker reflecting nutritional inflammatory status. This study aims to explore the association between ALI risk of fibrosis prognosis MAFLD patients. cross-sectional analyzed NHANES data from 1999–2018 on adult participants US. Weighted logistic regression assessed risk. Mortality outcomes, including all-cause, cardiovascular (CVD), cancer mortality, using weighted Kaplan-Meier Cox proportional hazards models. Restricted cubic splines (RCS) threshold effect analyses were uesd non-linear relationships. Receiver operating characteristic (ROC) curve evaluated prognostic value ALI, stratified examined subgroup differences. A total 6,858 patients (mean age 51.38 ± 17.22 years, 54% male) included. relationship was found risk, at 5.68, beyond which increased significantly (OR = 2.35, 95% CI: 1.89–2.95). Stronger associations observed subgroups central obesity prediabetes (P for interaction < 0.05). inversely associated all-cause mortality (HR 0.64, 0.56–0.72) CVD 0.57, 0.46–0.65), but not mortality. RCS analysis showed an L-shaped (threshold 5.36) linear Low HDL cholesterol excessive alcohol consumption influenced demonstrated highest predictive accuracy reduced highlighting potential assessing prognosis, particularly CVD-related

Language: Английский

The role of the advanced lung cancer inflammation index (ALI) in the risk of liver fibrosis and mortality among US adult MAFLD patients: a cross-sectional study of NHANES 1999–2018 DOI Creative Commons

Chunchun Yu,

L. Chen,

Wanting Hu

et al.

BMC Gastroenterology, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 20, 2025

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic globally, with inflammation and nutrition playing key roles in its progression. The Advanced Lung Cancer Inflammation Index (ALI) novel biomarker reflecting nutritional inflammatory status. This study aims to explore the association between ALI risk of fibrosis prognosis MAFLD patients. cross-sectional analyzed NHANES data from 1999–2018 on adult participants US. Weighted logistic regression assessed risk. Mortality outcomes, including all-cause, cardiovascular (CVD), cancer mortality, using weighted Kaplan-Meier Cox proportional hazards models. Restricted cubic splines (RCS) threshold effect analyses were uesd non-linear relationships. Receiver operating characteristic (ROC) curve evaluated prognostic value ALI, stratified examined subgroup differences. A total 6,858 patients (mean age 51.38 ± 17.22 years, 54% male) included. relationship was found risk, at 5.68, beyond which increased significantly (OR = 2.35, 95% CI: 1.89–2.95). Stronger associations observed subgroups central obesity prediabetes (P for interaction < 0.05). inversely associated all-cause mortality (HR 0.64, 0.56–0.72) CVD 0.57, 0.46–0.65), but not mortality. RCS analysis showed an L-shaped (threshold 5.36) linear Low HDL cholesterol excessive alcohol consumption influenced demonstrated highest predictive accuracy reduced highlighting potential assessing prognosis, particularly CVD-related

Language: Английский

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