Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment DOI Creative Commons
Teresa Urbano, Marco Vinceti, Chiara Carbone

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 933 - 933

Published: Dec. 22, 2024

Background: A limited number of studies have investigated the role environmental chemicals in etiology mild cognitive impairment (MCI). We performed a cross-sectional study association between exposure to selected trace elements and biomarkers decline. Methods: During 2019–2021, we recruited 128 newly diagnosed patients with MCI from two Neurology Clinics Northern Italy, i.e., Modena Reggio Emilia. At baseline, measured serum cerebrospinal fluid (CSF) concentrations cadmium, copper, iron, manganese, zinc using inductively coupled plasma mass spectrometry. With immuno-enzymatic assays, estimated β-amyloid 1-40, 1-42, Total Tau phosphorylated Tau181 proteins, neurofilament light chain (NfL), mini-mental state examination (MMSE) assess status. used spline regression explore shape each endpoint, adjusted for age at diagnosis, educational attainment, MMSE, sex. Results: In analyses CSF metals, found monotonic positive correlations copper zinc, while an inverse was observed cadmium. Serum cadmium were inversely associated amyloid ratio positively proteins. iron showed opposite trend, displayed heterogeneous non-linear associations biomarkers. Regarding biomarkers, only consistently ratio, Tau. Cadmium not appreciably NfL levels, inverted U-shaped NfL, similar that copper. CSF, element high concentrations. Conclusions: this study, impairment. Findings other difficult interpret, showing complex inconsistent neurodegenerative endpoints examined.

Language: Английский

Neurofilament light chain as a biomarker for neurodegenerative changes in COVID-19 and clinical implications DOI
Yousef Rasmi,

Yeganeh Farnamian,

Marijana Marković Boras

et al.

Future Virology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: March 21, 2025

Language: Английский

Citations

0
Cognitive reserve in young-onset cognitive impairment DOI Creative Commons
Chiara Carbone, Riccardo Maramotti, Erica Balboni

et al.

Brain and Cognition, Journal Year: 2025, Volume and Issue: 186, P. 106297 - 106297

Published: April 11, 2025

Language: Английский

Citations

0
Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination DOI Open Access
Anne Hege Aamodt, Thor Ueland, Marion Boldingh

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 22, 2024

Abstract Background and objectives New onset persistent headache has been reported following acute COVID-19 to some degree also after SARS-CoV-2 vaccination. The mechanisms for these types are unclear. purpose of this study was assess levels amyloid related biomarkers in patients with vaccine. Methods In prospective observational cohort, severe as the dominating symptom (n=29) vaccination (n=31), had neurological assessments reassessments 6 months. Plasma precursor protein (APP), pregnancy zone (PZP), cathepsin L1 (CTSL) serum Amyloid A (SAA1) were measured by ELISA relation healthy controls (n=16). Results We found a strong upregulation APP compared two other groups. At both inclusion months increased those accompanying cognitive symptoms. contrast, plasma PZP elevated at controls. CTSL only associated vaccine baseline, whereas SAA1 showed comparable all Conclusion Altered soluble markers potentially reflecting changes processing particular where we association NCT04576351 NCT05235776 What is already known on topic occurs subset individuals extent However, pathophysiological unknown. adds that could reflect How might affect research, practice or policy Our data underscore need more long-time follow-up new include blood tests neuroinflammation.

Language: Английский

Citations

0
Exposure to Cadmium and Other Trace Elements Among Individuals with Mild Cognitive Impairment DOI Creative Commons
Teresa Urbano, Marco Vinceti, Chiara Carbone

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(12), P. 933 - 933

Published: Dec. 22, 2024

Background: A limited number of studies have investigated the role environmental chemicals in etiology mild cognitive impairment (MCI). We performed a cross-sectional study association between exposure to selected trace elements and biomarkers decline. Methods: During 2019–2021, we recruited 128 newly diagnosed patients with MCI from two Neurology Clinics Northern Italy, i.e., Modena Reggio Emilia. At baseline, measured serum cerebrospinal fluid (CSF) concentrations cadmium, copper, iron, manganese, zinc using inductively coupled plasma mass spectrometry. With immuno-enzymatic assays, estimated β-amyloid 1-40, 1-42, Total Tau phosphorylated Tau181 proteins, neurofilament light chain (NfL), mini-mental state examination (MMSE) assess status. used spline regression explore shape each endpoint, adjusted for age at diagnosis, educational attainment, MMSE, sex. Results: In analyses CSF metals, found monotonic positive correlations copper zinc, while an inverse was observed cadmium. Serum cadmium were inversely associated amyloid ratio positively proteins. iron showed opposite trend, displayed heterogeneous non-linear associations biomarkers. Regarding biomarkers, only consistently ratio, Tau. Cadmium not appreciably NfL levels, inverted U-shaped NfL, similar that copper. CSF, element high concentrations. Conclusions: this study, impairment. Findings other difficult interpret, showing complex inconsistent neurodegenerative endpoints examined.

Language: Английский

Citations

0