Variability in Arterial Stiffness and Vascular Endothelial Function After COVID-19 During 1.5 Years of Follow-Up—Systematic Review and Meta-Analysis

Life, Journal Year: 2025, Volume and Issue: 15(4), P. 520 - 520

Published: March 21, 2025

Increasing long-term observations suggest that coronavirus disease 2019 (COVID-19) vasculopathy may persist even 1.5 years after the acute phase, potentially accelerating development of atherosclerotic cardiovascular diseases. This study systematically reviewed variability brachial flow-mediated dilation (FMD) and carotid-femoral pulse wave velocity (cfPWV) from phase COVID-19 through 16 months follow-up (F/U). Databases including PubMed, Web Science, MEDLINE, Embase were screened for a meta-analysis without language or date restrictions (PROSPERO reference CRD42025642888, last search conducted on 1 February 2025). The quality included studies was assessed using Newcastle–Ottawa Quality Scale. We considered all (interventional pre-post studies, prospective observational randomized, non-randomized trials) FMD cfPWV in adults (aged ≥ 18 years) with laboratory-confirmed compared non-COVID-19 controls changes these parameters during F/U. Twenty-one reported differences FMD, examined between patients control groups various stages: acute/subacute (≤30 days onset), early (>30–90 days), mid-term (>90–180 late (>180–270 very (>270 days) post-COVID-19 recovery. Six while nine did so Data 14 (627 cases 694 controls) 15 (578 703 our meta-analysis. showed significant decrease to (standardized mean difference [SMD]= −2.02, p < 0.001), partial improvements noted recovery (SMD = 0.95, 0.001) 0.92, 0.006). Normalization observed 0.12, 0.69). In contrast, values, which higher than 1.27, remained elevated throughout F/U, no except (SMD= −0.39, 0.001). recovery, values those 0.45, 0.010). manuscript, we discuss how factors, severity COVID-19, persistence syndrome, patient’s initial vascular age, depending metrics age risk influenced time degree improvement.

Language: Английский

Effect of Creatine Monohydrate Supplementation on Macro- and Microvascular Endothelial Function in Older Adults: A Pilot Study

Nutrients, Journal Year: 2024, Volume and Issue: 17(1), P. 58 - 58

Published: Dec. 27, 2024

Background/Objectives: A pilot study was conducted to investigate the effect of four weeks creatine monohydrate (CrM) on vascular endothelial function in older adults. Methods: In a double-blind, randomized crossover trial, twelve sedentary, healthy adults were allocated either CrM or placebo (PL) group for weeks, at dose 4 × 5 g/day days, followed by 1 23 days. Macrovascular (flow-mediated dilation [FMD%], normalized FMD%, brachial-ankle pulse wave velocity [baPWV], analysis [PWA]), microvascular (microvascular reperfusion rate [% StO2/sec]), and biomarkers (tetrahydrobiopterin [BH4], malondialdehyde [MDA], oxidized low-density lipoprotein [oxLDL], glucose, lipids) assessed pre- post-supplementation with four-week washout period. Results: significantly increased FMD% (pre-CrM, 7.68 ± 2.25%; post-CrM, 8.9 1.99%; p < 0.005), 2.57 10−4 1.03 10−4%/AUCSR; 3.42 1.69 0.05), compared PL. Microvascular rates following 2.29 1.42%/sec; 3.71 1.44%/sec; no change significant reduction fasting glucose 103.64 6.28; 99 4.9 mg/dL; 0.05) triglycerides 99.82 35.35; 83.82 37.65 observed CrM. No differences any other outcome. Conclusions: These data indicate that supplementation resulted favorable effects several indices

Language: Английский