SGLT-2i—A Useful Tool for Real-Life Metabolic and Body Weight Control in Type 2 Diabetes Mellitus Patients

Medicina, Journal Year: 2025, Volume and Issue: 61(3), P. 548 - 548

Published: March 20, 2025

Background and Objectives: Elevated blood sugar poses an increasingly significant challenge to healthcare systems worldwide. We aimed assess the efficacy of SGLT-2i class in achieving metabolic control patients with T2DM within a real-world standard-of-care regimen. Material Methods: A prospective analysis was conducted over 6 months including individuals receiving care outpatient department, baseline assessments follow-ups at 3 months. Results: total 280 were assessed, mean age 63.69 ± 9.16, 53.9% which males, DM duration 9.06 5.64 years, varying from 24 years. Discussion: Real-world evidence bridges gap between guidelines practice. It emphasizes need overcome clinical inertia order optimize patient outcomes contributes body supporting fixed-dose combinations managing associated comorbidities. Conclusions: demonstrate therapeutic impact setting. This medication not only positively influences glycemic weight but also reduces CV risk factors visceral adiposity.

Language: Английский

Association Between Pentraxins and Obesity in Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus Patients

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3661 - 3661

Published: April 12, 2025

Systemic inflammation has an important role in the prognosis and progression of many chronic diseases, including diabetes (T2DM). This retrospective study aimed to evaluate inflammatory status by determining serum biomarkers (PTX3, hs-CRP, TNF-α, IL-6) new indices, like mean corpuscular volume (MCV) lymphocyte ratio (MCVL) cumulative index (IIC), a cohort patients with prediabetes (PreDM) newly diagnosed T2DM. We also wanted assess association clinical parameters different obesity-related identify possible correlations diagnostic accuracy using ROC curve analysis. In this study, we included 60 T2DM 30 PreDM. The ELISA method was applied. Elevated PTX3, IL-6 levels were found compared preDM patients. An independent relationship between indices MCVL exhibited inverse trend proportional rising HbA1c group. Spearman’s analysis revealed group that PTX3 values correlated much better IIC (rho = 0.445, p-value 0.014) 0.338, 0.048). Hs-CRP expressed moderate-to-weak both groups. Additionally, showed (AUC 0.720; p 0.003; cut-off value 1888.00 pg/mL, 67.60% sensitivity 73.30% specificity) 0.677; 0.047; 39.60, 63.30% 66.70% have good, accurate diagnosis 0.866; < 0.0001; 40.30 100.00% 60.00% specificity). 61.70% specificity, AUC 0.572, 0.027 2.35. can serve as predictor factors patients, supporting their potential for management future research.

Language: Английский

Potential Association Between Atherogenic Coefficient, Prognostic Nutritional Index, and Various Obesity Indices in Diabetic Nephropathy

Nutrients, Journal Year: 2025, Volume and Issue: 17(8), P. 1339 - 1339

Published: April 14, 2025

Background/Objectives: Type 2 diabetes mellitus (T2DM), is a rapidly growing global health concern, often accompanied by chronic kidney disease (CKD) and metabolic disturbances. Obesity-related indices, such as the visceral adiposity index (VAI) body (BAI), have been linked to cardiovascular renal complications in diabetic patients. However, studies integrating both atherogenic coefficient (AC) prognostic nutritional (PNI) for evaluating nephropathy (DN) remain limited. This study aimed assess associations of obesity-related indices with immunological factors patients T2DM prediabetes (PreDM). Methods: A retrospective, cross-sectional was conducted over six months at university clinical hospital Dolj County, Romania. The enrolled 268 newly diagnosed 150 PreDM Anthropometric parameters, laboratory tests, demographic data were collected. AC PNI calculated using standard formulas, statistical analyses performed determine their inflammatory markers. Results: Our found that had significantly lower values, indicating mild malnutrition, while maintained normal status. higher patients, correlating lipid profile alterations systemic inflammation. Obesity particularly VAI, elevated values. Statistically significant differences total cholesterol, low-density lipoprotein cholesterol (LDL-c), triglycerides observed between subgroups, reinforcing its role risk assessment. Conclusions: findings highlight potential biomarkers assessing nutritional, inflammatory, lipemic status profiles, inflammation markers suggest early assessment these parameters may potentially aid predicting complications. Further are needed explore utility managing CKD progression. Future research should investigate how lipidic spectrum alters progression DN across various patient groups

Language: Английский