The Presence of Emphysema in Patients with Idiopathic Pulmonary Fibrosis and Lung Cancer: Impact on Tumor Features, Acute Exacerbation, and Survival DOI Open Access
Xiaoyi Feng,

Wenjing Zeng,

Xiafei Lv

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(11), P. 3862 - 3862

Published: May 30, 2025

Background: Idiopathic pulmonary fibrosis (IPF) and emphysema often coexist in patients with lung cancer (LC), forming a syndrome combined (CPFE). The three share the pathogenic mechanisms of smoking, chronic inflammation, oxidative stress. clinical management CPFE is challenging, but its impact on tumor characteristics, acute exacerbation (AE), prognosis still controversial. purpose this study was to clarify effect biological behavior, AE risk, survival outcome IPF-LC so as optimize individualized treatment strategies. Methods: This retrospective single-center study. Newly diagnosed LC IPF, COPD, normal lungs were recruited west China hospital. Patients IPF further categorized into CPFE-LC isolated groups based presence emphysema. Clinical features, function parameters, obtained compared. Results: more common older men heavy smokers. IPF-associated tumors had higher proportion carrying EGFR wild-type, occurring lower lobe developing adenocarcinoma squamous cell carcinoma. Among patients, 68.2% (103/151) met criteria. Pulmonary tests demonstrated preserved VC% significantly reduced FEV1/FVC versus non-emphysema (76.3% vs. 80.7%, p = 0.004), alongside elevated CPI impaired DLCO. ≥ 40 (HR 2.087, 95%CI: 1.715-6.089, 0.012), COPD 2.281, 1.139-4.569, 0.040), 5.703, 2.516-12.925, < 0.001), 6.275, 3.379-11.652, independent prognostic risk factors patients. incidence treatment-induced AEs (49.5% 29.2%, 0.038) AE-related mortality (28.0% 11.8%, 0.045) group than group. Logistic regression analysis showed that (OR: 3.494, 2.014-6.063, 0.001) independently associated IPF. Conclusions: Compared solely no significant overall survival, increased treatment-triggered mortality. In LC, worse AEs.

Language: Английский

Interstitial lung diseases and autoimmunity DOI Creative Commons
Е. Л. Насонов, L. P. Ananyeva, А. S. Belevskiy

et al.

Rheumatology Science and Practice, Journal Year: 2025, Volume and Issue: 63(2), P. 119 - 128

Published: May 1, 2025

Lung disease is one of the most common manifestations systemic autoimmune rheumatic diseases (SARDs), involving all parts respiratory system in pathological process. Interstitial lung (ILD) are great importance and often lead to development progressive pulmonary fibrosis (PPF). The following clinical categories patients distinguished within ILDs associated with SARDs (ILD-SARDs): ILD a reliable diagnosis SARDs; as first manifestation or interstitial pneumonia features. Clinical phenotypes ILD-SARDs vary from «asymptomatic» «rapidly progressing» related risk factors for damage. These should be considered conducting clinical, laboratory instrumental screening prescribing anti-inflammatory antifibrotic therapy. In pulmonology practice patient may have previously established SARDs, this could suspected based on number symptoms diseases. Problem diagnostic very complex, which determines multidisciplinary approach interaction rheumatologists, pulmonologists radiologists. possibilities perspectives pharmacotherapy rational use anti-inflammatory, immunomodulatory drugs. issues emphasized: identification rapidly progressing phenotype fibrosis; contribution inflammatory activity; effectiveness therapy relation leading “extrapulmonary” pneumotoxicity implementation “treat target” concept. greatest achievement chimeric antigen receptor (CAR) T-cell therapy, mechanism elimination pathogenic autoreactive B-cells. Preliminary data CAR indicate high efficacy wide range including progression sclerosis antisynthetase syndrome, there strong evidence important role mechanisms pathogenesis ILD.

Language: Английский

Citations

0
Clinical, Serological and Radiological Profile of Patients with Autoimmune Disease Associated Interstitial Lung Disease DOI
Hassan Ahmad, Muhammad Imran, Alam Zeb

et al.

Pakistan Journal of Health Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 36 - 42

Published: April 30, 2025

The clinical, serological, and radiological profiles of interstitial lung disease in patients with autoimmune diseases vary significantly are poorly studied. Objectives: To determine the serological profile autoimmune-associated disease. Methods: This cross-sectional study was carried out at Department Rheumatology, Khyber Teaching Hospital, Peshawar, during period from 16th December 2023 to 15th 2024. A total 105 male female age range 40 80 years diagnosed autoimmune-related were History, clinical examination, blood tests high-resolution computerized tomographic (HRCT) scan performed serologic radiologic features AI-ILD. Results: mean participants 51.51 ± 12.34 years. Female outnumbered men (n=61, 58.1%). Arthritis most commonly recorded 47 (44.8%) followed by skin rash (n=33, 31.4%). Antinuclear antibody (ANA) anti-dsdna (double-stranded deoxyribonucleic acid) constituted frequently found factors observed 32 (30.5%) 28 (26.7%) patients, respectively. Usual pneumonia 19 (17.4%), non-specific 36 (34.2%) lymphoid 7 (6.7%). Conclusions: It concluded that middle-aged women inflammatory arthritis rashes rheumatoid as background more likely have Serologic lack specificity. common finding on HRCT ground glass opacities frequent diagnosis.

Language: Английский

Citations

0
Pulmonary complications in children with systemic lupus erythematosus (SLE): A review of the literature DOI
Ahlam Mazi

The Egyptian Rheumatologist, Journal Year: 2025, Volume and Issue: 47(3), P. 148 - 155

Published: May 7, 2025

Language: Английский

Citations

0
Connective Tissue Disorder-Induced Diffuse Alveolar Hemorrhage: A Comprehensive Review with an Emphasis on Airway and Respiratory Management DOI Creative Commons
Mayuri Mudgal, Swetha Balaji,

Ajeetha Priya Gajendiran

et al.

Life, Journal Year: 2025, Volume and Issue: 15(5), P. 793 - 793

Published: May 15, 2025

Diffuse alveolar hemorrhage (DAH), a catastrophic complication of connective tissue disorders (CTDs), manifests as rapid-onset hypoxemia, infiltrates, and progressive bleeding into the airways. While immune-mediated alveolar–endothelial injury primarily drives its pathophysiology, diagnosis is based on bronchoscopy chest imaging. The clinical urgency lies in securing compromised airway stabilizing respiratory failure, challenge increased by CTD-specific anatomical alterations such cervical spine instability, cricoarytenoid arthritis, subglottic stenosis. High-dose corticosteroids immunosuppression are essential, while severe cases require extracorporeal membrane oxygenation or plasmapheresis. This comprehensive review introduces two novel approaches to address fundamental gaps management CTD-induced DAH: structured algorithm for risk stratification tool, integrating screening application lung ultrasounds (LUSs) post-intubation DAH ventilation management. need multidisciplinary team approach also discussed. Despite aggressive care, mortality remains high (25–50%), underscoring necessity improved early recognition intervention strategies these high-risk patients.

Language: Английский

Citations

0
The Presence of Emphysema in Patients with Idiopathic Pulmonary Fibrosis and Lung Cancer: Impact on Tumor Features, Acute Exacerbation, and Survival DOI Open Access
Xiaoyi Feng,

Wenjing Zeng,

Xiafei Lv

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(11), P. 3862 - 3862

Published: May 30, 2025

Background: Idiopathic pulmonary fibrosis (IPF) and emphysema often coexist in patients with lung cancer (LC), forming a syndrome combined (CPFE). The three share the pathogenic mechanisms of smoking, chronic inflammation, oxidative stress. clinical management CPFE is challenging, but its impact on tumor characteristics, acute exacerbation (AE), prognosis still controversial. purpose this study was to clarify effect biological behavior, AE risk, survival outcome IPF-LC so as optimize individualized treatment strategies. Methods: This retrospective single-center study. Newly diagnosed LC IPF, COPD, normal lungs were recruited west China hospital. Patients IPF further categorized into CPFE-LC isolated groups based presence emphysema. Clinical features, function parameters, obtained compared. Results: more common older men heavy smokers. IPF-associated tumors had higher proportion carrying EGFR wild-type, occurring lower lobe developing adenocarcinoma squamous cell carcinoma. Among patients, 68.2% (103/151) met criteria. Pulmonary tests demonstrated preserved VC% significantly reduced FEV1/FVC versus non-emphysema (76.3% vs. 80.7%, p = 0.004), alongside elevated CPI impaired DLCO. ≥ 40 (HR 2.087, 95%CI: 1.715-6.089, 0.012), COPD 2.281, 1.139-4.569, 0.040), 5.703, 2.516-12.925, < 0.001), 6.275, 3.379-11.652, independent prognostic risk factors patients. incidence treatment-induced AEs (49.5% 29.2%, 0.038) AE-related mortality (28.0% 11.8%, 0.045) group than group. Logistic regression analysis showed that (OR: 3.494, 2.014-6.063, 0.001) independently associated IPF. Conclusions: Compared solely no significant overall survival, increased treatment-triggered mortality. In LC, worse AEs.

Language: Английский

Citations

0