The Role of the Gut–Biliary–Liver Axis in Primary Hepatobiliary Liver Cancers: From Molecular Insights to Clinical Applications

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(4), P. 124 - 124

Published: March 24, 2025

Background: Hepatobiliary liver cancers (HBLCs) represent the sixth most common neoplasm in world. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) constitute main HBLC types, with alarming epidemiological projections. Methods: In recent decades, alterations gut microbiota, mutual implications on gut–liver axis gut–biliary permeability status, have been massively investigated proposed as pathogenetic deus ex machina. Results: HCC setting, elevated intestinal levels of Escherichia coli other Gram-negative bacteria demonstrated, resulting a close association increased lipopolysaccharide (LPS) serum and, consequently, chronic systemic inflammation. contrast, microbiota individuals feature reduced Lactobacillus spp., Bifidobacterium Enterococcus spp. CC evidence has revealed an expression enhanced Actynomices Alloscardovia Besides impaired strains/species representation, gut-derived metabolites, including bile acids (BAs), short-chain fatty (SCFAs), oxidative-stress-derived products, configure network severely impacting progression HBLC. Conclusions: era Precision Medicine, clarification composition functioning settings can contribute to identification individual signatures, potentially providing novel diagnostic markers, therapeutic approaches, prognostic/predictive tools.

Language: Английский

Electrochemical biosensors for hepatocellular carcinoma

Clinica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 120328 - 120328

Published: April 1, 2025

Language: Английский

Abbreviated MRI for Hepatocellular Carcinoma Screening: A Comprehensive Review

Current Hepatology Reports, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 29, 2025

Language: Английский