Molecular Mechanisms Underlying Anticancer and Anti-Inflammatory Activities of Oridonin in Oral Squamous Cell Carcinoma DOI Creative Commons
Ome Kalsoom Afridi, Abdus Salam,

Habib Ullah Jan

et al.

BioScientific Review, Journal Year: 2025, Volume and Issue: 7(1), P. 124 - 142

Published: May 6, 2025

Background. Oral squamous cell carcinoma (OSCC) constitutes one of the most common pathological forms oral cancers. Oridonin is an ent-kaurane diterpenoid compound isolated from Rabdosia rubescens. Recently, anticancer potential has been extensively studied in breast, osteosarcoma, myeloma, neuroblastoma, lymphoma, pancreatic, colon, leukemia, and esophageal The largely unexplored OSCC. Method. This study aimed to provide insights into multifunctional activities We carried out extensive critical literature survey on research related importance medicinal plants various cancers, role as agents OSCC up 2025 using keywords apoptotic proteins, antitumor activities, cycle arrest, diterpenoid, inflammasomes, Notch signaling pathway, natural products, Oridonin, carcinoma, cancer treatment. Results. induces apoptosis cells (OCC) by regulating mitochondrial ROS-mediated JNK/p38 MAPK, acting blocker at G2/M phase pathways, increasing expression γH2AX. plays essential tumorigenesis inhibiting phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. Blocking dysregulation specific inhibition NLRP3 inflammasome are other cellular mechanism which can exhibit its activities. Conclusion. serve a drug due involvement multiple pathways.

Language: Английский

Artificial intelligence-driven clinical decision support systems for early detection and precision therapy in oral cancer: a mini review DOI Creative Commons

Manoj Kumar Karuppan Perumal,

Remya Rajan Renuka,

Suresh Kumar

et al.

Frontiers in Oral Health, Journal Year: 2025, Volume and Issue: 6

Published: April 28, 2025

Oral cancer (OC) is a significant global health burden, with life-saving improvements in survival and outcomes being dependent on early diagnosis precise treatment planning. However, planning are predicated the synthesis of complicated information derived from clinical assessment, imaging, histopathology patient histories. Artificial intelligence-based decision support systems (AI-CDSS) provides viable solution that can be implemented via advanced methodologies for data analysis, better diagnostic prognostic evaluation. This review presents AI-CDSS as promising through comprehensive analysis. In addition, it examines current implementations facilitate OC detection, staging, personalized by processing multimodal machine learning, computer vision, natural language processing. These effectively interpret results, identify critical disease patterns (including stage, site, tumor dimensions, histopathologic grading, molecular profiles), construct profiles. approach allows reduction delays improved intervention outcomes. Moreover, also optimizes plans basis unique parameters, stages risk factors, providing therapy.

Language: Английский

Citations

0
Molecular Mechanisms Underlying Anticancer and Anti-Inflammatory Activities of Oridonin in Oral Squamous Cell Carcinoma DOI Creative Commons
Ome Kalsoom Afridi, Abdus Salam,

Habib Ullah Jan

et al.

BioScientific Review, Journal Year: 2025, Volume and Issue: 7(1), P. 124 - 142

Published: May 6, 2025

Background. Oral squamous cell carcinoma (OSCC) constitutes one of the most common pathological forms oral cancers. Oridonin is an ent-kaurane diterpenoid compound isolated from Rabdosia rubescens. Recently, anticancer potential has been extensively studied in breast, osteosarcoma, myeloma, neuroblastoma, lymphoma, pancreatic, colon, leukemia, and esophageal The largely unexplored OSCC. Method. This study aimed to provide insights into multifunctional activities We carried out extensive critical literature survey on research related importance medicinal plants various cancers, role as agents OSCC up 2025 using keywords apoptotic proteins, antitumor activities, cycle arrest, diterpenoid, inflammasomes, Notch signaling pathway, natural products, Oridonin, carcinoma, cancer treatment. Results. induces apoptosis cells (OCC) by regulating mitochondrial ROS-mediated JNK/p38 MAPK, acting blocker at G2/M phase pathways, increasing expression γH2AX. plays essential tumorigenesis inhibiting phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) pathway. Blocking dysregulation specific inhibition NLRP3 inflammasome are other cellular mechanism which can exhibit its activities. Conclusion. serve a drug due involvement multiple pathways.

Language: Английский

Citations

0