Regional hippocampal thinning and gyrification abnormalities and associated cognition in children with prenatal alcohol exposure

Journal of Neurodevelopmental Disorders, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 5, 2025

Abstract Background Prenatal alcohol exposure (PAE) impacts hippocampal structure and function, contributing to deficits in memory decision-making affected individuals. Here, we evaluate anomalies children with PAE an unexposed comparison group using advanced MRI methods that characterize curvature thickness. Methods Participants, ages 8 16 years, included ( n = 48) 46) who underwent a dysmorphology exam, neuropsychological assessment, scan. Height, weight, head circumference, dysmorphic facial features were evaluated. Of those PAE, 4.2% had fetal syndrome (FAS), 22.9% partial FAS, 72.9% alcohol-related neurodevelopmental disorder. Neuropsychological testing measures of intelligence functioning. T1-weighted anatomical data processed the Hippunfold pipeline, which “unfolds” complex onto template surface provides thickness gyrification/curvature at each vertex. Permutation Analysis Linear Models (PALM) was used test for differences (PAE vs. comparison) gyrification vertex also assess correlations cognitive Results There significant regional across bilateral hippocampi, showing substantially thinner tissue less than group, especially CA1 subiculum regions. For subicular (bilateral) associated lower IQ. Also episodic performance thinness right hippocampus, region. no patterns functioning individuals group. Conclusions We novel method The suggest disrupts development, impacting both early-stage folding its ultimate demonstrate these developmental have functional consequences terms core functions as well global intellectual PAE.

Language: Английский

Transition from care experiences of youth aged 13 to 23 living with fetal alcohol spectrum disorder in Canada: A scoping review

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100172 - 100172

Published: April 1, 2025

Language: Английский

The Invisible Struggle: Parents with FASD, the Courts and the Child Intervention System

Social Sciences, Journal Year: 2024, Volume and Issue: 13(9), P. 497 - 497

Published: Sept. 20, 2024

Fetal alcohol spectrum disorder (FASD) encompasses a range of complex neurodevelopmental challenges that arise because maternal use during pregnancy. Contrary to previous beliefs, FASD is wide-ranging condition mostly invisible, affecting cognitive, social, and daily living skills. Furthermore, with may present other challenges, such as mental health issues, substance abuse, engagement in criminal behavior. long-term disability requires support across the lifespan. The main objective this research was determine what, if anything, has changed since prior review 2020 parents appearing child intervention courts Canada. We found eleven relevant reported cases throughout Canada from 2024 where had confirmed diagnosis or potential be eligible for our study. Within these cases, only one parent able reunite their children strong supportive system they had. There were four ongoing contact between child(ren) permitted, Additionally, we professionals lack education regarding skills people demonstrate. A person seen through lens rather than strengths-based approach, creating stigma, fear, power imbalance. Stigma an impact not just on how see make decisions but also policymakers, funding, governments social groups. Individuals are often reluctant report fear being judged having taken care. Thus, unable obtain access services, even when do have access, must navigate own. Parents who involved required participate many programs simultaneously, potentially resulting overwhelming experience.

Language: Английский