Oxidative stress and metabolic syndrome in Alzheimer’s disease: the search for a relationship DOI Creative Commons
N. M. Zalutskaya, Dubinina Ev, N. A. Gomzyakova

et al.

V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, Journal Year: 2024, Volume and Issue: 58(4-2), P. 20 - 28

Published: Dec. 15, 2024

The article addresses the problem of Alzheimer’s disease (AD) from perspective interaction between two important pathological processes: oxidative stress and metabolic disorders. Although histopathological changes in early senile dementia are similar, both variants attributed to AD, individuals with early-onset AD (EOAD) demonstrate a more aggressive course rapid cognitive decline fewer concomitant morphological changes. development late-onset (LOAD) depends on multiple environmental factors, lifestyle, and, among other things, functioning general adaptation mechanisms, including redox, immunological, hormonal systems. pays special attention role syndrome (MS) as an risk factor not only for cardiovascular cerebrovascular diseases but also AD. presence MS over 60 years age increases developing by 13% under 8% ages 70. emphasizes importance (OS), which causes oxidation biomolecules tissue damage, pathogenesis disorders MS. Possible mechanisms relationship processes described. Understanding development, well their interrelation, is key effective methods preventing treating these diseases.

Language: Английский

Clinical Significance of Early-Onset Alzheimer’s Mutations in Asian and Western Populations: A Scoping Review DOI Open Access

Prevathe Poniah,

Aswir Abd Rashed, Julaina Abdul Jalil

et al.

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 345 - 345

Published: March 17, 2025

Background/Objectives: Background: Early-onset Alzheimer’s disease (EOAD) is primarily inherited in an autosomal dominant pattern, with mutations the APP, PSEN1, and PSEN2 genes being central contributors. Diagnosing poses challenges due to coexistence of various co-pathologies, treatment options remain limited for most patients, apart from familial cases linked specific genetic mutations. While significant research on genetics has been conducted both Asian Caucasian populations, their clinical impacts EOAD are still inadequately explored. This review aims provide a detailed analysis commonly reported associated features patients Western populations. Methods: Following PRISMA-ScR guidelines, systematic database search was studies published between 2016 2023. After screening 491 records, 36 cohorts 40 met inclusion criteria. Results: The revealed 127 unique population 190 population. About 16.7% 21.9% covered sporadic AD, consistent patterns across groups. Some were shared populations displayed similar features, while others population-specific. Conclusions: These findings underscore considerable variability phenotypes, emphasizing importance testing younger enhance diagnostic accuracy guide strategies effectively.

Language: Английский

Citations

0
Epigenetic Biomarkers in Alzheimer's Disease: Diagnostic and Prognostic Relevance DOI
Tapan Behl,

Ashishkumar Kyada,

R Roopashree

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 102, P. 102556 - 102556

Published: Oct. 30, 2024

Language: Английский

Citations

3
Etiology of Late-Onset Alzheimer’s Disease, Biomarker Efficacy, and the Role of Machine Learning in Stage Diagnosis DOI Creative Commons
M Manju Sarma, Subarna Chatterjee

Diagnostics, Journal Year: 2024, Volume and Issue: 14(23), P. 2640 - 2640

Published: Nov. 23, 2024

Late-onset Alzheimer's disease (LOAD) is a subtype of dementia that manifests after the age 65. It characterized by progressive impairments in cognitive functions, behavioral changes, and learning difficulties. Given nature disease, early diagnosis crucial. Early-onset (EOAD) solely attributable to genetic factors, whereas LOAD has multiple contributing factors. A complex pathway mechanism involving factors contributes progression. Employing systems biology approach, our analysis encompassed genetic, epigenetic, metabolic, environmental modulate molecular networks pathways. These affect brain's structural integrity, functional capacity, connectivity, ultimately leading manifestation disease. This study aggregated diverse biomarkers associated with capable altering pathways influence brain structure, functionality, connectivity. serve as potential indicators for AD are designated biomarkers. The other biomarker datasets related parameters an individual broadly categorized clinical-stage compiled research papers on (AD) utilizing machine (ML) methodologies from both categories data, including applications ML techniques diagnosis. broad objectives gap identification, assessment efficacy, most effective or prevalent technology used paper examines predominant use deep (DL) convolutional neural (CNNs) various types data. Furthermore, this addressed scope using generative AI Synthetic Minority Oversampling Technique (SMOTE) data augmentation.

Language: Английский

Citations

1
Role of Thrombosis in Neurodegenerative Diseases: An Intricate Mechanism of Neurovascular Complications DOI
Samir Kumar Beura, Abhishek Panigrahi, Pooja Yadav

et al.

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 62(4), P. 4802 - 4836

Published: Nov. 1, 2024

Language: Английский

Citations

0
Oxidative stress and metabolic syndrome in Alzheimer’s disease: the search for a relationship DOI Creative Commons
N. M. Zalutskaya, Dubinina Ev, N. A. Gomzyakova

et al.

V M BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY, Journal Year: 2024, Volume and Issue: 58(4-2), P. 20 - 28

Published: Dec. 15, 2024

The article addresses the problem of Alzheimer’s disease (AD) from perspective interaction between two important pathological processes: oxidative stress and metabolic disorders. Although histopathological changes in early senile dementia are similar, both variants attributed to AD, individuals with early-onset AD (EOAD) demonstrate a more aggressive course rapid cognitive decline fewer concomitant morphological changes. development late-onset (LOAD) depends on multiple environmental factors, lifestyle, and, among other things, functioning general adaptation mechanisms, including redox, immunological, hormonal systems. pays special attention role syndrome (MS) as an risk factor not only for cardiovascular cerebrovascular diseases but also AD. presence MS over 60 years age increases developing by 13% under 8% ages 70. emphasizes importance (OS), which causes oxidation biomolecules tissue damage, pathogenesis disorders MS. Possible mechanisms relationship processes described. Understanding development, well their interrelation, is key effective methods preventing treating these diseases.

Language: Английский

Citations

0