Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones DOI Creative Commons
Takanobu Takata, Shinya Inoué,

Kenshiro Kunii

et al.

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 7 - 7

Published: Jan. 2, 2025

Urinary stones (urolithiasis) have been categorized as kidney (renal calculus), ureteric (ureteral calculus and ureterolith), bladder (bladder urethral (urethral calculus); however, the mechanisms underlying their promotion related injuries in glomerular tubular cells remain unclear. Although lifestyle-related diseases (LSRDs) such hyperglycemia, type 2 diabetic mellitus, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, cardiovascular disease are risk factors for urolithiasis, Recently, heat shock protein 90 (HSP90) on membrane of HK-2 human proximal epithelium has associated with adhesion urinary cytotoxicity. Further, HSP90 pancreatic breast can be modified by various advanced glycation end-products (AGEs), thus affecting function. Hypothesis 1: We hypothesized that HSP90s on/in types AGEs, they may affect functions it a key to reveal LSRDs urolithiasis. 2: considered possibility Japanese traditional medicines urolithiasis inhibit AGE generation. Of Choreito Urocalun (the extract Quercus salicina Blume/Quercus stenophylla Makino) used clinic, is Kampo medicine, while characteristic medicine. As contains quercetin, hesperidin, p-hydroxy cinnamic acid, which generation, we generation AGE-modified cells.

Language: Английский

Advanced Glycation End-Product-Modified Heat Shock Protein 90 May Be Associated with Urinary Stones DOI Creative Commons
Takanobu Takata, Shinya Inoué,

Kenshiro Kunii

et al.

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 7 - 7

Published: Jan. 2, 2025

Urinary stones (urolithiasis) have been categorized as kidney (renal calculus), ureteric (ureteral calculus and ureterolith), bladder (bladder urethral (urethral calculus); however, the mechanisms underlying their promotion related injuries in glomerular tubular cells remain unclear. Although lifestyle-related diseases (LSRDs) such hyperglycemia, type 2 diabetic mellitus, non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, cardiovascular disease are risk factors for urolithiasis, Recently, heat shock protein 90 (HSP90) on membrane of HK-2 human proximal epithelium has associated with adhesion urinary cytotoxicity. Further, HSP90 pancreatic breast can be modified by various advanced glycation end-products (AGEs), thus affecting function. Hypothesis 1: We hypothesized that HSP90s on/in types AGEs, they may affect functions it a key to reveal LSRDs urolithiasis. 2: considered possibility Japanese traditional medicines urolithiasis inhibit AGE generation. Of Choreito Urocalun (the extract Quercus salicina Blume/Quercus stenophylla Makino) used clinic, is Kampo medicine, while characteristic medicine. As contains quercetin, hesperidin, p-hydroxy cinnamic acid, which generation, we generation AGE-modified cells.

Language: Английский

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