The Interplay between Metabolic Syndrome and Oral Health – A Possible Unexpected Link with Cognitive Dysfunction DOI Creative Commons

Andrei Cătălin Oprescu,

Lidia Iuliana Arhire, Otilia Niță

et al.

Journal of Medical and Health Studies, Journal Year: 2024, Volume and Issue: 5(3), P. 11 - 21

Published: Aug. 1, 2024

Metabolic syndrome (MetS) is not a single disease but cluster of conditions that significantly increase medical risks. It typically defined by the presence five metabolic risk factors: atherogenic dyslipidaemia, high blood pressure, hyperglycaemia, prothrombotic state, and proinflammatory state. MetS global pandemic involves chronic inflammation insulin resistance, leading to higher risks heart disease, diabetes, stroke, other disabilities. also includes visceral adiposity, endothelial dysfunction, genetic susceptibility, hypertension. The connections between MetS, cognition, oral health are complex multifaceted. This narrative review aims describe relationships each pair broader interconnection among all three. has bidirectional relationship with health, influenced resistance local inflammation, impacting both masticatory function glycaemic control. Additionally, there significant link involving various aspects daily life, such as poor hygiene practices, nutritional deficiencies, intricate biological mechanisms, including inflammatory immunological responses. Nutrition plays crucial role in influencing three areas. Essential nutrients proteins, carbohydrates, fats, minerals, vitamins vital for maintaining improving cognitive function, health. factors affecting interrelated. Poor nutrition can lead which impair issues. Furthermore, oxidative stress, common involved decline periodontal disease. Among different factors, malnutrition, antioxidants, omega-3 fatty acids, dietary fibers especially crucial, they collectively aid processes, prevent decline, support Healthcare professionals must understand mechanisms linking develop effective preventive therapeutic strategies.

Language: Английский

Role of Vitamin-E as a Vital Nutrient in Health and Diseases DOI
Ghizal Fatima,

Andrej Džupina,

Abbas Ali Mahdi

et al.

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Language: Английский

Citations

2
The need for effective interprofessional collaboration between nutrition and dentistry DOI Creative Commons

J J Kaye,

Sara Lee,

Courtney Chinn

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 26, 2025

There are bidirectional relationships between diet and nutrition, systemic health oral health. Diet nutrition fundamental to the prevention management of chronic diseases. Systemic can impact And influence nutrition. The 2020 Surgeon General's Report "Oral Health in America" stated that is an integral factor development disease overall. Within medical model, Registered Dietitians have been impactful members a multidisciplinary team by providing therapy nutritional counseling reduce diseases like obesity, diabetes cardiovascular disease. Despite well-established collaboration role plays outcomes, there limited documented dentistry. purpose this paper review current evidence settings compared identify specific challenges, suggest possible next steps for collaboration. intended outcome will be provide reader with insight about need integrate into both education clinical practice address prevalent increase equity those at high risk.

Language: Английский

Citations

0
Unveiling the immune and vitamin profiles of blood: the potential biomarkers for alopecia areata DOI Creative Commons
Jin Ke, Fangfang Chen, Yu‐Pei Chen

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19430 - e19430

Published: May 7, 2025

Background Alopecia areata is a hair follicle disorder characterized by the development of multiple circular bald patches on scalp, often accompanied elevated cytokine production and immune cell infiltration around follicles. Our aspiration to explore whether blood analysis can reveal additional factors that contribute disparities between individuals with alopecia those who are healthy. Such research could potentially establish robust foundation for advancement future therapeutic strategies. Methods In Fujian, China, we have collected samples from cohort 28 patients control group healthy comparative analysis. A detailed assessment cytokines, eosinophil counts, vitamin levels, immunoglobulin profiles within these was conducted. Subsequently, statistical applied elucidate differences two groups. Results While revealed higher average levels IL-4, IL-10, TNF-α in compared individuals, were not statistically significant. Similarly, showed no significant variation patient However, Wilcoxon rank sum test identified increase IFN-γ decrease IgG4 among patients, pointing possible role disease’s pathogenesis. Receiver operating characteristic (ROC) curve had demonstrated area under ROC (AUC) 0.656 0.704, respectively, suggesting certain discrimination effect areata. Utilizing Youden index optimize specificity, propose below 824.85 mg/L above 0.565 pg/mL serve as biomarkers assessing risk Conclusions These findings highlight need further exploration link areata, IgG4- IFN-γ-related mechanisms, uncovering novel targets managing this condition.

Language: Английский

Citations

0
Application of machine learning for the analysis of peripheral blood biomarkers in oral mucosal diseases: a cross-sectional study DOI Creative Commons

Huiyu Yao,

Zhuo Cao,

Liang‐Fu Huang

et al.

BMC Oral Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 10, 2025

Oral mucosal lesions are widespread globally, have a high prevalence in clinical practice, and significantly impact patients' quality of life. However, their pathogenesis remains unclear. Recent evidences suggested that hematological parameters may play role development. Our study investigated the differences humoral immune indexes, serum vitamin B levels, micronutrients among patients with oral healthy controls. Additionally, it evaluated Random Forest machine learning model for classifying various diseases based on peripheral blood biomarkers. We recruited 237 recurrent aphthous ulcers (RAU), 35 lichen planus (OLP), 67 atrophic glossitis (AG), burning mouth syndrome (BMS), 82 Clinical data were analyzed by SPSS 24 software. Serum levels immunoglobulins (IgG, IgA, IgM), complements (C3, C4), (VB1, VB2, VB3, VB5), zinc (Serum Zn), iron Fe), unsaturated iron-binding capacity (UIBC), total (TIBC), saturation (Iron Sat) measured compared groups. A was applied to analyze dataset comprising 319 samples eight key Significant observed between groups controls VB5, zinc, iron, TIBC, Iron Sat. Specifically, VB2 VB3 higher (*p < 0.05), while Zn, Fe, Sat lower 0.05). No significant found C3, C4, IgG, IgM, VB1, UIBC. The optimized demonstrated performance, effectively classified different disease groups, though some overlap noted. Feature importance analysis, Mean Decrease Accuracy Gini Index, identified Zn as biomarkers, indicating potential distinguishing diseases. associations contents other lesions. It regulating these micronutrient could be essential preventing curing such accuracy (94.68%) emphasizing enhance diagnostic precision Future research should focus validating findings larger cohorts exploring alternative machine-learning algorithms improve further.

Language: Английский

Citations

0
Development and Evaluation of the Biological Activities of a Plain Mucoadhesive Hydrogel as a Potential Vehicle for Oral Mucosal Drug Delivery DOI Creative Commons

Ana G. Pardo-Rendón,

Jorge L. Mejía-Méndez, Edgar R. López-Mena

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 574 - 574

Published: Sept. 3, 2024

This study aimed to develop HGs based on cationic guar gum (CGG), polyethylene glycol (PEG), propylene (PG), and citric acid (CA) using a 2

Language: Английский

Citations

2
Oral Tori Findings in an Adult Albanian Population: A Single-Center Pilot Study DOI Creative Commons
Valbona Disha,

Bora Zaimi,

Elizana Petrela

et al.

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(8), P. 242 - 242

Published: July 30, 2024

Tori are bony growths in the mouth caused by genetic and environmental factors. Oral tori may grow over time interfere with oral hygiene, speech, mastication, application of dentures. The aim this study was to evaluate prevalence patterns torus mandibularis palatinus according age gender among people Albania. A single-center pilot conducted at Diamond Dental Hospital (DDH) from 1 February 30 April 2024 Tirana, Written consent obtained each participant. patients were interviewed one trained researcher examined intraorally experienced examiner. Photographs taken any positive findings. sample Albania very high 48%, peak incidence 18–29 group (54%). most common type mandibularis, a 39%. prevalent form flat (71%) solitary bilateral (48%). This found Its not related or bruxism. professionals should note occurrence their importance dental practice.

Language: Английский

Citations

0
The Interplay between Metabolic Syndrome and Oral Health – A Possible Unexpected Link with Cognitive Dysfunction DOI Creative Commons

Andrei Cătălin Oprescu,

Lidia Iuliana Arhire, Otilia Niță

et al.

Journal of Medical and Health Studies, Journal Year: 2024, Volume and Issue: 5(3), P. 11 - 21

Published: Aug. 1, 2024

Metabolic syndrome (MetS) is not a single disease but cluster of conditions that significantly increase medical risks. It typically defined by the presence five metabolic risk factors: atherogenic dyslipidaemia, high blood pressure, hyperglycaemia, prothrombotic state, and proinflammatory state. MetS global pandemic involves chronic inflammation insulin resistance, leading to higher risks heart disease, diabetes, stroke, other disabilities. also includes visceral adiposity, endothelial dysfunction, genetic susceptibility, hypertension. The connections between MetS, cognition, oral health are complex multifaceted. This narrative review aims describe relationships each pair broader interconnection among all three. has bidirectional relationship with health, influenced resistance local inflammation, impacting both masticatory function glycaemic control. Additionally, there significant link involving various aspects daily life, such as poor hygiene practices, nutritional deficiencies, intricate biological mechanisms, including inflammatory immunological responses. Nutrition plays crucial role in influencing three areas. Essential nutrients proteins, carbohydrates, fats, minerals, vitamins vital for maintaining improving cognitive function, health. factors affecting interrelated. Poor nutrition can lead which impair issues. Furthermore, oxidative stress, common involved decline periodontal disease. Among different factors, malnutrition, antioxidants, omega-3 fatty acids, dietary fibers especially crucial, they collectively aid processes, prevent decline, support Healthcare professionals must understand mechanisms linking develop effective preventive therapeutic strategies.

Language: Английский

Citations

0