
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: June 10, 2024
Arterial compliance (AC) plays a crucial role in vascular aging and cardiovascular disease. The ability to continuously estimate aortic AC or its surrogate, pulse pressure (PP), through wearable devices is highly desirable, given strong association with daily activities. While the single-site photoplethysmography (PPG)-derived arterial stiffness indices show reasonable correlations AC, they are susceptible noise interference, limiting their practical use. To overcome this challenge, our study introduces noise-resistant indicator of AC: Katz’s fractal dimension (KFD) PPG signals. We showed that KFD integrated signal complexity arising from changes across cardiac cycle structural complexity, thereby decreasing dependence on individual characteristic points. assess capability measuring we conducted comprehensive evaluation using both silico studies 4374 virtual human data real-world measurements. In studies, demonstrated correlation ( r = 0.75), which only experienced slight decrease 0.66 at signal-to-noise ratio 15dB, surpassing best PPG-morphology-derived measure 0.41) under same condition. addition, observed KFD’s sensitivity varied based individual’s hemodynamic status, may further enhance accuracy estimations. These findings were supported by measurements encompassing diverse health conditions. conclusion, suggests PPG-derived has potential reliably monitor compliance, enabling unobtrusive assessment health.
Language: Английский