Ex vivo propofol permeation across nasal mucosa: A proof-of-concept study for outpatient light sedation via nasal route

ADMET & DMPK, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 16, 2024

Background and Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection. Experimental approach: Dilution of with methyl-b-cyclodextrin in saline solution increased solubility water diffusion epithelium. Key results conclusion: Despite these positive effects cyclodextrin, amount PPF permeated was minimal 3 h, exceeding formulation residence time nose. These highlight key role need innovation transmucosal transport enhancement techniques optimize drug delivery therapeutic efficacy.

Language: Английский

Procedural Sedation and Analgesia in an Australian Emergency Department: Results of the First 3 Months of a Procedural Sedation Registry

Anesthesia Research, Journal Year: 2024, Volume and Issue: 1(3), P. 157 - 167

Published: Oct. 1, 2024

Background: Procedural sedation and analgesia (PSA) is commonly performed in emergency departments (EDs) to reduce anxiety, discomfort, or pain during a procedure. The primary goal of PSA produce state relaxation drowsiness without eliminating the patient’s protective reflexes. Despite discovery new techniques medications deliver PSA, there paucity research evaluating EDs over last decade. We aim describe current practice an Australian tertiary mixed ED with 75,000 presentations per year. Methods: A retrospective study initial 3 months registry, which was part Tasmanian Emergency Care Outcomes Registry, analyzed; Results: All told, 80 consecutive cases were entered 3-month period, pediatric patients (<14 years old) making up 35% all cases. Joint reductions (17, 39%) fracture (13, 29%) most common indications for adult population, whilst (9, 36%), laceration repairs (7, 28%), other distressing procedures 28%) cohort. Pharmacological approaches also differed between groups, ketamine (25, 92%) preferred cohort combination propofol fentanyl (22, 42%) No adverse events recorded 6 (8%) minor occurred no severe occurring either more frequently at 0900–1000 incidence reduced 0000 0800. Conclusions: our both safe effective, non-severe complication rates similar those reported literature. Severe complications are rare therefore larger will be required assess this aspect. approach different populations needs differentiate populations.

Language: Английский

Deep Sedation in High-Risk Patients Undergoing Emergency Upper GI Endoscopy: A Retrospective Study Assessing Safety and Effectiveness

Translational Medicine UniSa, Journal Year: 2024, Volume and Issue: 26(2)

Published: Dec. 27, 2024

Emergency upper gastrointestinal (GI) endoscopy is often prolonged and complex, performed during high-risk conditions. These procedures can be affected by an increased risk for airway compromise. Scarce literature found providing guidance on anesthesiological conduct GI in Emergency. This was a monocentric retrospective study conducted 96 patients treated the Gastroenterology Unit at AORN Cardarelli, between June October 2023. Key features of moderate deep sedation were investigated. There no statistically significant difference incidence complications respiratory depression receiving versus those with sedation. Adverse outcomes analgesia endoscopic are rare, even state

Language: Английский