Journal of Cancer Metastasis and Treatment,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 1, 2024
Aim:
The
purpose
of
this
study
is
to
enhance
the
understanding
bladder
cancer
and
role
cancer-associated
fibroblasts
(CAFs)
in
its
progression.
We
aim
identify
CAF-specific
biomarkers
develop
a
prognostic
prediction
model
based
on
CAFs,
thereby
contributing
advancement
treatment
strategies
identification
predictive
for
cancer.
Method:
employed
single-cell
RNA
sequencing
detect
CAFs
cells.
Bladder
cohorts
were
categorized
into
low-
high-CAF
groups
using
ssGSEA
algorithm.
also
explored
association
between
CAF-related
scores,
immune-related
cells,
immune
checkpoint-related
genes.
Furthermore,
we
performed
GSVA
analysis
understand
biological
features
their
link
various
cancer-related
pathways.
Result:
Ten
genes
identified
as
CAF
markers
A
significant
difference
was
found
with
2712
differentially
expressed
low-CAF
tissues.
CAFs-based
included
nine
(ALDH1L2,
AL450384.2,
EMP1,
LINC02362,
WFIKKN1,
GOLGA8A,
POU5F1,
AL354919.2,
PTPRR),
which
are
potentially
crucial
predicting
prognosis.
revealed
involvement
several
pathways,
such
WNT,
toll-like
receptor,
TGF-beta,
MAPK,
MTOR
signaling
model.
Conclusion:
This
highlights
progression
prognosis
constructed
provide
valuable
insights
future
research
potential
therapeutic
targets.
CAF-dependent
pathways
promising
development
new
treatments
improving
patients.
Mathematical Biosciences & Engineering,
Journal Year:
2023,
Volume and Issue:
20(5), P. 8583 - 8600
Published: Jan. 1, 2023
<abstract><p>The
planning
of
urban
public
health
spatial
can
not
only
help
people's
physical
and
mental
but
also
to
optimize
protect
the
environment.
It
is
great
significance
study
methods
spatial.
The
application
effect
traditional
poor,
in
this
paper,
using
big
data
technology
visual
communication
Internet
Things
(IoT)
proposed.
First,
architecture
established
IoT,
which
divided
into
perception
layer,
network
layer
layer;
Second,
information
collection
performed
at
used
simplify
model
information,
automatically
sort
out
data,
establish
a
space
evaluation
system
according
type
characteristics
data;
Finally,
planned
based
on
assessment
results
design
concept
through
layer.
show
that
when
number
regions
reaches
60,000,
maximum
time
region
merging
7.86s.
percentage
fitting
error
0.17.
height
0.31m.
average
deviation
coordinates
0.23,
realize
different
spaces.</p></abstract>
Journal of Clinical Medicine Research,
Journal Year:
2023,
Volume and Issue:
15(3), P. 133 - 138
Published: March 1, 2023
Different
machine
learning
(ML)
technologies
have
been
applied
in
healthcare
systems
with
diverse
applications.
We
aimed
to
determine
the
model
feasibility
and
accuracy
of
predicting
patient
portal
use
among
diabetic
patients
by
using
six
different
ML
algorithms.
In
addition,
we
also
compared
performance
only
essential
variables.This
was
a
single-center
retrospective
observational
study.
From
March
1,
2019
February
28,
2020,
included
all
from
study
emergency
department
(ED).
The
primary
outcome
status
use.
A
total
18
variables
consisting
sociodemographic
characteristics,
ED
clinic
information,
medical
conditions
were
predict
Six
algorithms
(logistic
regression,
random
forest
(RF),
deep
forest,
decision
tree,
multilayer
perception,
support
vector
machine)
used
for
such
predictions.
During
initial
step,
predictions
performed
variables.
Then,
chosen
via
feature
selection.
Patient
repeated
accuracies
(overall
accuracy,
sensitivity,
specificity,
area
under
receiver
operating
characteristic
curve
(AUC))
compared.A
77,977
unique
placed
our
final
analysis.
Among
them,
23.4%
(18,223)
mellitus
(DM).
found
26.9%
DM
patients.
Overall,
above
80%
five
out
RF
outperformed
others
when
(accuracy
0.9876,
sensitivity
0.9454,
specificity
0.9969,
AUC
0.9712).
When
eight
chosen,
still
0.9374,
0.9932,
0.9769).It
is
possible
outcomes
are
fair
accuracy.
However,
similar
prediction
accuracies,
selection
techniques
can
improve
interpretability
addressing
most
relevant
features.
Medicine,
Journal Year:
2023,
Volume and Issue:
102(13), P. e33296 - e33296
Published: March 31, 2023
Dengue
fever
(DF)
is
a
significant
public
health
concern
in
Asia.
However,
detecting
the
disease
using
traditional
dichotomous
criteria
(i.e.,
absent
vs
present)
can
be
extremely
difficult.
Convolutional
neural
networks
(CNNs)
and
artificial
(ANNs),
due
to
their
use
of
large
number
parameters
for
modeling,
have
shown
potential
improve
prediction
accuracy
(ACC).
To
date,
there
has
been
no
research
conducted
understand
item
features
responses
online
Rasch
analysis.
verify
hypothesis
that
combination
CNN,
ANN,
K-nearest-neighbor
algorithm
(KNN),
logistic
regression
(LR)
ACC
DF
children,
further
required.We
extracted
19
feature
variables
related
symptoms
from
177
pediatric
patients,
whom
69
were
diagnosed
with
DF.
Using
RaschOnline
technique
analysis,
we
examined
11
statistical
significance
predicting
risk
Based
on
2
sets
data,
1
training
(80%)
other
testing
(20%),
calculated
by
comparing
areas
under
receiver
operating
characteristic
curve
(AUCs)
between
+
DF-
both
sets.
In
set,
compared
scenarios:
combined
scheme
individual
algorithms.Our
findings
indicate
visual
displays
data
are
easily
interpreted
analysis;
k-nearest
neighbors
lower
AUC
(<0.50);
LR
relatively
higher
(0.70);
all
3
algorithms
an
almost
equal
(=0.68),
which
smaller
than
Naive
Bayes,
raw
Bayes
normalized
data;
developed
app
assist
parents
children
during
dengue
season.The
development
LR-based
APP
detection
completed.
help
family
members,
clinicians
differentiate
febrile
illnesses
at
early
stage,
11-item
model
proposed
developing
APP.
Journal of Circuits Systems and Computers,
Journal Year:
2023,
Volume and Issue:
33(07)
Published: Oct. 27, 2023
Battery
Management
System
(BMS)
functions
to
monitor
individual
cell
in
a
battery
pack
and
its
crucial
task
is
maintain
stability
throughout
the
pack.
The
BMS
responsible
for
maintaining
safety
of
as
well
not
harm
user
or
environment.
parameters
that
are
be
monitored
Voltage,
Current
Temperature.
With
collected
data,
carefully
monitors
charging–discharging
behavior
particularly
Lithium-ion
(Li-ion)
batteries
which
charging
discharging
completely
different.
This
paper
proposes
real-time
IOT
connected
deep
learning
algorithm
estimation
State-of-Charge
(SoC)
Li-ion
batteries.
provides
unique
objectives
congruence
between
model-based
conventional
methods
state-of-the-art
algorithm,
specifically
Feed
Forward
Neural
Network
(FNN)
nonRecurrent.
also
highlights
advantages
Internet-of-Things
(IoT)
Hybrid
Electric
Vehicles
(HEVs)
(EVs).
major
advantage
proposed
method
Artificial
Intelligence
(AI)-based
techniques
aim
bring
error
less
than
2%
at
low
cost
time
without
model
battery,
par
with
Extended
Kalman
Filter
(EKF)
best
ever
practical
theory.
Another
an
abnormal
condition
(i.e.,
Unsafe
Temperature)
IF
Then
That
(IFTTT)
IoT
mobile
application
interfaced
through
ThingSpeak
cloud,
sends
notification
alert
expert
prior
emergency.
Finally,
data
cloud
platform
future
research
analysis.
Journal of Cancer Metastasis and Treatment,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 1, 2024
Aim:
The
purpose
of
this
study
is
to
enhance
the
understanding
bladder
cancer
and
role
cancer-associated
fibroblasts
(CAFs)
in
its
progression.
We
aim
identify
CAF-specific
biomarkers
develop
a
prognostic
prediction
model
based
on
CAFs,
thereby
contributing
advancement
treatment
strategies
identification
predictive
for
cancer.
Method:
employed
single-cell
RNA
sequencing
detect
CAFs
cells.
Bladder
cohorts
were
categorized
into
low-
high-CAF
groups
using
ssGSEA
algorithm.
also
explored
association
between
CAF-related
scores,
immune-related
cells,
immune
checkpoint-related
genes.
Furthermore,
we
performed
GSVA
analysis
understand
biological
features
their
link
various
cancer-related
pathways.
Result:
Ten
genes
identified
as
CAF
markers
A
significant
difference
was
found
with
2712
differentially
expressed
low-CAF
tissues.
CAFs-based
included
nine
(ALDH1L2,
AL450384.2,
EMP1,
LINC02362,
WFIKKN1,
GOLGA8A,
POU5F1,
AL354919.2,
PTPRR),
which
are
potentially
crucial
predicting
prognosis.
revealed
involvement
several
pathways,
such
WNT,
toll-like
receptor,
TGF-beta,
MAPK,
MTOR
signaling
model.
Conclusion:
This
highlights
progression
prognosis
constructed
provide
valuable
insights
future
research
potential
therapeutic
targets.
CAF-dependent
pathways
promising
development
new
treatments
improving
patients.