Synthesis, Physicochemical Characterization, and Antimicrobial Evaluation of Ureasil-Polyether Coatings with Silver Nanoparticles for Hospital Devices

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: April 7, 2025

Language: Английский

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Identification of Microbial-Based Natural Products as Potential CYP51 Inhibitors for Eumycetoma Treatment: Insights from Molecular Docking, MM-GBSA Calculations, ADMET Analysis, and Molecular Dynamics Simulations

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 598 - 598

Published: April 20, 2025

Background/Objectives: Eumycetoma, caused by Madurella mycetomatis, is a chronic fungal infection with limited treatment options and increasing drug resistance. CYP51, key enzyme in ergosterol biosynthesis, well-established target for azole antifungals. However, existing drugs demonstrate efficacy treating eumycetoma. Microbial-based natural products, their structural diversity bioactivity, offer promising source novel CYP51 inhibitors. This study aimed to identify potential mycetomatis inhibitors from microbial products using molecular docking, MM-GBSA calculations, ADMET analysis, dynamics (MD) simulations. Methods: Virtual screening was conducted on library of microbial-based an in-house homology model itraconazole as the reference drug. The top compounds initial docking were refined through Standard Extra Precision docking. calculations assessed binding affinities, analysis evaluated drug-like properties. Compounds favorable properties underwent MD Results: computational investigations identified 34 better scores affinity than itraconazole. Of these, 9 interacted heme group residues active site CYP51. In silico pharmacokinetic profiling 3 candidates, simulations confirmed Conclusions: highlights microbial-derived particularly monacyclinone G, H, I, candidates inhibition, eumycetoma, requiring further experimental validation.

Language: Английский

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Gut Mycobiome: Latest Findings and Current Knowledge Regarding Its Significance in Human Health and Disease

Journal of Fungi, Journal Year: 2025, Volume and Issue: 11(5), P. 333 - 333

Published: April 22, 2025

The gut mycobiome, the fungal component of microbiota, plays a crucial role in health and disease. Although fungi represent small fraction ecosystem, they influence immune responses, homeostasis, disease progression. mycobiome’s composition varies with age, diet, host factors, its imbalance has been linked to conditions such as inflammatory bowel (IBD) metabolic disorders. Advances sequencing have expanded our understanding fungi, but challenges remain due methodological limitations high variability between individuals. Emerging therapeutic strategies, including antifungals, probiotics, fecal microbiota transplantation, dietary interventions, show promise require further study. This review highlights recent discoveries on interactions bacteria, disease, potential clinical applications. A deeper contributions will help develop targeted microbiome-based therapies.

Language: Английский

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Antifungal resistance and stewardship: a knowledge, attitudes and practices survey among pharmacy students at the University of Zambia; findings and implications

JAC-Antimicrobial Resistance, Journal Year: 2023, Volume and Issue: 5(6)

Published: Nov. 1, 2023

Antifungal resistance (AFR) is a growing global public health concern. Little currently known about knowledge, attitudes and practices regarding AFR antifungal stewardship (AFS) in Zambia, across the globe. To address this evidence gap, we conducted study through questionnaire design starting with pharmacy students as they include next generation of healthcare professionals.A cross-sectional among 412 from June 2023 to July using structured questionnaire. Multivariable analysis was used determine key factors influence.Of participants, 55.8% were female, 81.6% aged between 18 25 years. Most had good knowledge (85.9%) positive (86.7%) but sub-optimal (65.8%) towards AFS. Overall, 30.2% accessed antifungals without prescription. Male less likely report (adjusted OR, AOR = 0.55, 95% CI: 0.31-0.98). Similarly, residing urban areas attitude (AOR 0.35, 0.13-0.91). Fourth-year also compared second-year 0.48, 0.27-0.85).Good must translate into toward AFS going forward. Consequently, there need provide educational interventions where have low scores In addition, implement strategies reduce inappropriate dispensing antifungals, especially prescription, Zambia.

Language: Английский

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Formulation and Development of a Herbal Antifungal Gel Containing Origanum vulgare and Syzygium aromaticum Essential Oils Against Oral Candida albicans

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 17, 2024

Background Oral candidiasis is the most prevalent oral fungal infection, and existing antifungal agents have side effects such as drug intolerance, resistance, toxicity. Herbal essential oils are emerging an alternative therapeutic approach for treating infections

Language: Английский

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