Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 31, 2024
Magnetic
nanoparticles
(MNPs)
are
of
great
interest
for
their
wide
applications
in
biomedical
applications,
such
as
bioimaging,
antitumoral
therapies,
regenerative
medicine,
and
drug
delivery.
The
work
aimed
to
obtain
biocompatible
magnetite
coated
with
amino
acids
the
general
formula
Fe
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
175, P. 116668 - 116668
Published: May 2, 2024
The
combination
of
radiation
treatment
and
chemotherapy
is
currently
the
standard
for
management
cancer
patients.
However,
safe
doses
do
not
often
provide
effective
therapy,
then
pre-treated
patients
are
forced
to
repeat
with
already
increased
tumor
resistance
drugs
irradiation.
One
solutions
we
suggest
improve
primary
course
via
enhancing
radiosensitivity
tumors
by
magnetic-guided
iron
oxide
nanoparticles
(magnetite).
We
obtained
spherical
heparinized
(hIONPs,
∼20
nm),
characterized
it
TEM,
Infrared
spectroscopy
DLS.
Then
hIONPs
cytotoxicity
was
assessed
colon
cells
(XTT
assay)
cellular
uptake
analyzed
X-ray
fluorescence.
Combination
ionizing
(IR)
in
vitro
caused
an
increase
G2/M
arrest
cell
cycle,
mitotic
errors
decrease
survival
(compared
samples
exposed
IR
separately).
promising
results
were
shown
CT26-grafted
BALB/C
mice:
intravenously
administrated
showed
20,8%
T/C
ratio
(related
non-treated
mice),
while
single
had
no
significant
growth
(72,4%).
Non-guided
magnets
57,9%
T/C.
This
indicates
that
ultra-small
size
biocompatible
molecule
key
successful
nano-drug
design,
each
case,
delivery
technologies
need
be
improved
when
transferred
vivo
model.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Oct. 31, 2024
Magnetic
nanoparticles
(MNPs)
are
of
great
interest
for
their
wide
applications
in
biomedical
applications,
such
as
bioimaging,
antitumoral
therapies,
regenerative
medicine,
and
drug
delivery.
The
work
aimed
to
obtain
biocompatible
magnetite
coated
with
amino
acids
the
general
formula
Fe