Multi-scale wastewater surveillance at a Bangkok tertiary care hospital: A potential sentinel site for real-time COVID-19 surveillance at hospital and national levels DOI Creative Commons
Quinton Hayre, Supaporn Wacharapluesadee, Piyapha Hirunpatrawong

et al.

PLOS Global Public Health, Journal Year: 2025, Volume and Issue: 5(4), P. e0004256 - e0004256

Published: April 8, 2025

Wastewater-based epidemiology is a valuable tool for population-level pathogen surveillance, complementing clinical methods. While most sampling focuses on municipal wastewater treatment plants, emerging evidence suggests collected from hospital settings can lead to targeted interventions. To investigate surveillance in further, we tracked the presence and concentration of SARS-CoV-2 RNA across multi-scale sample sites within large, public tertiary care Bangkok, Thailand. From July 2022 May 2023, weekly samples (n=392) were various including non-clinical facilities, as well hospital’s plant. Influent at center yielded consistent detection all sites, with 26 samples. Despite varied building usage patterns, significant moderate negative correlations found 90% (9/10) between RT-PCR cycle threshold values case data national reports. Targeting specific buildings distinct trends, indicating their potential offer complementary insights into viral shedding transmission among sub-populations campus. Our findings suggest that wastewater-based reflects broader community disease which may be especially useful regions limited coverage. Large hospitals could serve effective cost-efficient sentinel future monitoring, guiding health actions.

Language: Английский

Multi-scale wastewater surveillance at a Bangkok tertiary care hospital: A potential sentinel site for real-time COVID-19 surveillance at hospital and national levels DOI Creative Commons
Quinton Hayre, Supaporn Wacharapluesadee, Piyapha Hirunpatrawong

et al.

PLOS Global Public Health, Journal Year: 2025, Volume and Issue: 5(4), P. e0004256 - e0004256

Published: April 8, 2025

Wastewater-based epidemiology is a valuable tool for population-level pathogen surveillance, complementing clinical methods. While most sampling focuses on municipal wastewater treatment plants, emerging evidence suggests collected from hospital settings can lead to targeted interventions. To investigate surveillance in further, we tracked the presence and concentration of SARS-CoV-2 RNA across multi-scale sample sites within large, public tertiary care Bangkok, Thailand. From July 2022 May 2023, weekly samples (n=392) were various including non-clinical facilities, as well hospital’s plant. Influent at center yielded consistent detection all sites, with 26 samples. Despite varied building usage patterns, significant moderate negative correlations found 90% (9/10) between RT-PCR cycle threshold values case data national reports. Targeting specific buildings distinct trends, indicating their potential offer complementary insights into viral shedding transmission among sub-populations campus. Our findings suggest that wastewater-based reflects broader community disease which may be especially useful regions limited coverage. Large hospitals could serve effective cost-efficient sentinel future monitoring, guiding health actions.

Language: Английский

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