Changes in DNA methylation contribute to rapid adaptation in bacterial plant pathogen evolution

PLoS Biology, Journal Year: 2024, Volume and Issue: 22(9), P. e3002792 - e3002792

Published: Sept. 20, 2024

Adaptation is usually explained by beneficial genetic mutations that are transmitted from parents to offspring and become fixed in the adapted population. However, mutation analysis alone not sufficient fully explain adaptive processes, several studies report existence of nongenetic (or epigenetic) inheritance can enable adaptation new environments. In present work, we tested hypothesis role DNA methylation, a form epigenetic modification, plant pathogen Ralstonia pseudosolanacearum host during experimental evolution. Using SMRT-seq technology, analyzed methylomes 31 experimentally evolved clones obtained after serial passages on 5 different species 300 generations. Comparison with methylome ancestral clone revealed list 50 differential methylated sites (DMSs) at GTWWAC motif. Gene expression 39 genes targeted these DMSs limited correlation between methylation corresponding genes. Only 1 gene showed correlation, RSp0338 encoding EpsR regulator protein. The MSRE-qPCR used as an alternative approach for analysis, also found 2 upstream RSp0338. site-directed mutagenesis, demonstrated contribution adaptation. As appeared very early evolution, hypothesize such fast changes allow rapid stem environment. addition, change remains stable least 100 generations outside thus contribute long-term plant. To our knowledge, this first study showing direct link bacterial variation

Language: Английский

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Exploring the ameliorative potential of rutin against High-Sucrose Diet-induced oxidative stress and reproductive toxicity in Drosophila melanogaster

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 130, P. 108742 - 108742

Published: Nov. 5, 2024

Language: Английский

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Elucidating the clonal relationship of esophageal second primary tumors in patients with laryngeal squamous cell carcinoma

Infectious Agents and Cancer, Journal Year: 2023, Volume and Issue: 18(1)

Published: Nov. 28, 2023

Abstract Laryngeal cancer ranks as the second most prevalent upper airway malignancy, following Lung cancer. Although some progress has been made in managing laryngeal cancer, 5-year survival rate is disappointing. The gradual increase incidence of primary tumors (SPTs) plays a crucial role determining outcomes during long-term follow-up, and esophagus was common site with worse prognosis. In clinical practice, treatment esophageal (ESPT) patients squamous cell carcinoma (LSCC) always challenging. For synchronous tumors, several modalities, such radiotherapy, chemotherapy potentially curative surgery are necessary but typically poorly tolerated. Secondary therapy options for metachronous constrained by index indications. Therefore, understanding clonal origin tumor may be an important issue patients. LSCC cells demonstrate genetic instability because two distinct aetiologies (human papillomavirus (HPV)-negative HPV-positive) disease. Various etiologies exhibit oncogenic mechanisms, which subsequently impact tissue microenvironment. condition microenvironment destiny makeup mutant initial stages tumorigenesis. This review focuses on advances LSCC, current research status SPT, influence key carcinogenesis HPV-positive HPV-negative evolution ESPT cells. objective to gain comprehensive molecular basis underlying origins thereby offering novel perspectives future investigations this field.

Language: Английский

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Epigenetics as a driver of adaptive evolution

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 41 - 91

Published: Jan. 1, 2024

Language: Английский

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Aquatic Animal Nutrition: Plant Preparations—‘Ever Tried. Ever Failed. Try Again.’

Published: Jan. 1, 2024

Language: Английский

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Epigenetic Resources: Gaps in Aquatic Animal Germplasm Research

Reviews in Aquaculture, Journal Year: 2024, Volume and Issue: 17(1)

Published: Dec. 5, 2024

ABSTRACT Aquatic animal germplasm research plays a vital role in biodiversity conservation and sustainable aquaculture. The traditional view is that diversity of resources commonly attributed to genetic variation. However, recent studies transgenerational epigenetics have shown epigenetic information can also be passed down offspring, which consistent with the definition germplasm. Therefore, it necessary define information, such as DNA methylation, histone modifications, ncRNAs, through generations, incorporate them into concept Germplasm should include not only but resources. Epigenetic variation arise from genetic, environmental, or stochastic factors. Genetic co‐determine phenotypic traits. It has been demonstrated inherited across generations aquatic animals. modification, ncRNAs are involved addressing environmental challenges, maintaining diversity, improving breeding strategies, combating inbreeding decline, age determination. future on important for conservation, development, utilization. This review proposes new theoretical framework elucidate place collects articles past 8 years explore inheritance Integrating enhances our understanding population dynamics, adaptation, evolutionary processes, thereby informing strategies enhancing aquaculture practices. By considering both resources, we address challenges facing more comprehensively.

Language: Английский

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