The Role of Whey in Functional Microorganism Growth and Metabolite Generation: A Biotechnological Perspective DOI Creative Commons

I. G. Malos,

Andra-Ionela Ghizdareanu, Livia Vidu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1488 - 1488

Published: April 24, 2025

The valorization of cheese whey, a rich by-product the dairy industry that is in lactose (approx. 70%), proteins (14%), and minerals (9%), represents promising approach for microbial fermentation. With global whey production exceeding 200 million tons annually, high biochemical oxygen demand underlines important need sustainable processing alternatives. This review explores biotechnological potential as fermentation medium by examining its chemical composition, interactions, ability to support synthesis valuable metabolites. Functional microorganisms such lactic acid bacteria (Lactobacillus helveticus, L. acidophilus), yeasts (Kluyveromyces marxianus), actinobacteria, filamentous fungi (Aspergillus oryzae) have demonstrated efficiently convert into wide range bioactive compounds, including organic acids, exopolysaccharides (EPSs), bacteriocins, enzymes, peptides. To enhance growth metabolite production, can be carried out using various techniques, batch, fed-batch, continuous immobilized cell fermentation, membrane bioreactors. These bioprocessing methods improve substrate utilization yields, contributing efficient whey. compounds diverse applications food, pharmaceuticals, agriculture, biofuels strengthen role resource. Patents clinical studies confirm bioactivities whey-derived metabolites their industrial potential. Whey peptides provide antihypertensive, antioxidant, immunomodulatory, antimicrobial benefits, while bacteriocins EPSs act natural preservatives foods pharmaceuticals. Also, acids propionic biopreservatives food safety health-promoting formulations. results emphasize whey’s significant relevance sustainable, cost-efficient high-quality pharmaceutical, agricultural, bioenergy sectors.

Language: Английский

Bioengineering in Solid-State Fermentation for next sustainable food bioprocessing DOI Creative Commons
Muyideen Olaitan Bamidele, Micheal Bola Bamikale, Eliseo Cárdenas-Hernández

et al.

Next Sustainability, Journal Year: 2025, Volume and Issue: 6, P. 100105 - 100105

Published: Jan. 1, 2025

Language: Английский

Citations

8

Where Biology Meets Engineering: Scaling Up Microbial Nutraceuticals to Bridge Nutrition, Therapeutics, and Global Impact DOI Creative Commons
Ahmed M. Elazzazy, Mohammed N. Baeshen,

Khalid M. Alasmi

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 566 - 566

Published: March 2, 2025

The global nutraceutical industry is experiencing a paradigm shift, driven by an increasing demand for functional foods and dietary supplements that address malnutrition chronic diseases such as obesity, diabetes, cardiovascular conditions, cancer. Traditional plant- animal-derived nutraceuticals face limitations in scalability, cost, environmental impact, paving the way microbial biotechnology sustainable alternative. Microbial cells act bio-factories, converting nutrients like glucose amino acids into valuable products polyunsaturated fatty (PUFAs), peptides, other bioactive compounds. By harnessing their natural metabolic capabilities, microorganisms efficiently synthesize these compounds, making production effective approach development. This review explores transformative role of platforms nutraceuticals, emphasizing advanced fermentation techniques, synthetic biology, engineering. It addresses challenges optimizing strains, ensuring product quality, scaling while navigating regulatory frameworks. Furthermore, highlights cutting-edge technologies CRISPR/Cas9 genome editing, adaptive evolution strain enhancement, bioreactor innovations to enhance yield efficiency. With focus on sustainability precision, positioned game-changer industry, offering eco-friendly scalable solutions meet health needs. integration omics exploration novel sources hold potential revolutionize this field, aligning with growing consumer innovative products.

Language: Английский

Citations

4

Technological Innovations and Applications of Microbial Protein Production: From Genetic Engineering to Sustainable Manufacturing DOI Creative Commons
Youlong Xu, Yixuan Gao, Dong Liu

et al.

Fermentation, Journal Year: 2025, Volume and Issue: 11(3), P. 133 - 133

Published: March 10, 2025

Facing global climate change, resource shortages, and the urgent need for carbon neutrality goals, microbial protein production has demonstrated significant potential in fields of food, pharmaceuticals, industrial applications [...]

Language: Английский

Citations

0

Effect of Non-Meat Protein Addition on the 3D Printing Performance of Chicken Meat DOI Creative Commons
Xin Li, Mingyuan Huang, Dan Chen

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(6), P. 1015 - 1015

Published: March 17, 2025

In this study, three types of non-meat proteins, including soybean protein, wheat gluten, and whey were used as additives to improve the 3D printing performance chicken meat. The effects proteins on rheological behavior, textural properties, moisture characteristics, microstructure gels investigated. Chicken meat paste without added was taken a control. Rheological results showed that addition increased apparent viscosity storage modulus paste. Textural properties gels, hardness, chewiness, cohesiveness, springiness, resilience also improved. with protein became denser more compact, improved connectivity. Nuclear magnetic resonance signals bound water, immobilized free water moved left towards lower relaxation time (p < 0.05) part immobile changed water. samples containing 15% exhibited good shape-forming shape-keeping capacities. There an obvious increase in hardness (1991.40 ± 88.22 g), springiness (0.92 0.00), cohesiveness (0.72 0.01), gumminess (1299.14 21.21), (0.34 0.01) these samples. cooking loss 2.46 0.36%, which significantly than other treatments 0.05). summary, protein-added great potential for printing.

Language: Английский

Citations

0

Industrial Microbial Technologies for Feed Protein Production from Non-Protein Nitrogen DOI Creative Commons
Yu‐Xin Ye, Yafan Cai, Wang Fei

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(4), P. 742 - 742

Published: March 25, 2025

Due to the increasing global demand for feed protein, microbial protein has great potential of being able sustainably. However, application in animal cultivation industry is still limited by its high cost and availability on scale. From viewpoint industrial production, it vital specify crucial processes components further technical exploration process optimization. This article presents state-of-the-art technologies non-protein nitrogen (NPN) assimilation production. Nitrogen sources are one main factors media used large-scale fermentation. Therefore, available NPN synthesis, utilization mechanisms, fermentation corresponding strain reviewed this paper. Especially, random mutagenesis adaptive laboratory evolution (ALE) approach combined with (ultra-) throughput screening provided impetus increase yield. Despite underlying technological advances production extensive research development efforts required before commercial feed.

Language: Английский

Citations

0

The Role of Whey in Functional Microorganism Growth and Metabolite Generation: A Biotechnological Perspective DOI Creative Commons

I. G. Malos,

Andra-Ionela Ghizdareanu, Livia Vidu

et al.

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1488 - 1488

Published: April 24, 2025

The valorization of cheese whey, a rich by-product the dairy industry that is in lactose (approx. 70%), proteins (14%), and minerals (9%), represents promising approach for microbial fermentation. With global whey production exceeding 200 million tons annually, high biochemical oxygen demand underlines important need sustainable processing alternatives. This review explores biotechnological potential as fermentation medium by examining its chemical composition, interactions, ability to support synthesis valuable metabolites. Functional microorganisms such lactic acid bacteria (Lactobacillus helveticus, L. acidophilus), yeasts (Kluyveromyces marxianus), actinobacteria, filamentous fungi (Aspergillus oryzae) have demonstrated efficiently convert into wide range bioactive compounds, including organic acids, exopolysaccharides (EPSs), bacteriocins, enzymes, peptides. To enhance growth metabolite production, can be carried out using various techniques, batch, fed-batch, continuous immobilized cell fermentation, membrane bioreactors. These bioprocessing methods improve substrate utilization yields, contributing efficient whey. compounds diverse applications food, pharmaceuticals, agriculture, biofuels strengthen role resource. Patents clinical studies confirm bioactivities whey-derived metabolites their industrial potential. Whey peptides provide antihypertensive, antioxidant, immunomodulatory, antimicrobial benefits, while bacteriocins EPSs act natural preservatives foods pharmaceuticals. Also, acids propionic biopreservatives food safety health-promoting formulations. results emphasize whey’s significant relevance sustainable, cost-efficient high-quality pharmaceutical, agricultural, bioenergy sectors.

Language: Английский

Citations

0