Gut fermentation syndrome as an alibi for a driver tested positive for alcohol: a case-based discussion DOI Creative Commons
Ewa Toruńska, Piotr Engelgardt, Maciej Krzyżanowski

et al.

Problems of Forensic Sciences, Journal Year: 2024, Volume and Issue: 139, P. 179 - 191

Published: Dec. 19, 2024

The intestinal fermentation syndrome (IFS) also known as the auto-brewery (ABS), is an extremely rare diagnosis. This involves endogenous production of alcohol by microorganisms in digestive system after consuming a high-carbohydrate meal. article describes case 65-year-old driver who was found to have 0.24 mg/l during sobriety test, which, according Polish law, defined state and considered misdemeanour. He explained his condition occurrence syndrome. After thorough analysis documentation submitted, it concluded that there no basis for assuming ethyl exhaled air resulted from accused’s health condition, medications taken him or meals consumed, presence discussed disease excluded. specificity encourages use diagnosis alibi detected body. Hence, such cases, important carefully conduct diagnostics, including differential diagnosis, microbiological tests and, above all, provocation test with glucose simultaneous monitoring level During possibility additional intake should be excluded avoid false results misdiagnosis.

Language: Английский

Endogenous ethanol production in health and disease DOI
Abraham S. Meijnikman, Max Nieuwdorp, Bernd Schnabl

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(8), P. 556 - 571

Published: June 3, 2024

Language: Английский

Citations

14

A catalog of ethanol-producing microbes in humans DOI

Babacar Mbaye,

Reham Magdy Wasfy, Maryam Tidjani Alou

et al.

Future Microbiology, Journal Year: 2024, Volume and Issue: 19(8), P. 697 - 714

Published: May 3, 2024

Aim: Endogenous ethanol production emerges as a mechanism of nonalcoholic steatohepatitis, obesity, diabetes and auto-brewery syndrome. Methods: To identify ethanol-producing microbes in humans, we used the NCBI taxonomy browser PubMed database with an automatic query manual verification. Results: 85 human were identified. Saccharomyces cerevisiae, Candida Pichia most represented fungi. Enterobacteriaceae was bacterial family mainly Escherichia coli Klebsiella pneumoniae. Species Lachnospiraceae Clostridiaceae family, Lactobacillales order Bifidobacterium genus also Conclusion: This catalog will help study pathophysiology, diagnosis, prevention management diseases associated endogenous production.

Language: Английский

Citations

3

Ethanol and Higher Alcohols’ Production in Fungal and Bacterial Laboratory Cultures and Significance for Forensic Samples DOI Creative Commons
Vassiliki A. Boumba,

Glykeria Velivasi,

N. Kourkoumelis

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(3), P. 462 - 462

Published: Feb. 24, 2024

Ethanol can be produced by many microorganisms that colonize a dead body. Ethanol’s concentration depends on the congener higher alcohols, 1-propanol, isobutanol, 2-methyl-1-butanol, 3-methyl-1-butanol, and 1-butanol, as previous research has shown. This correlation is expressed mathematical models which estimate of microbial ethanol. The aim this contribution was to study ethanol alcohols’ production in various laboratory bacterial fungal cultures applicability (which concern bacteria E. coli, S. aureus, K. pneumoniae, faecalis, fungus C. albicans) these samples, well blood samples from autopsy cases, with overall objective investigating models’ routine casework. were cultured conventional culture media denatured human under conditions. concentrations determined using head space–gas chromatography–flame ionization detector (HS-GC-FID). previously reported yeast applied 122 cases. Our results showed 1-propanol not albicans faecalis certain Also, 1-butanol albicans, pneumonia Furthermore, applicable postmortem irrespective microbes possibly activated sample, while EC best among all models. observed 0.10 g/L < BAC 1.0 cases violent undetermined causes death putrefaction. Finally, limited, special, In conclusion, it could inferred source any given sample likely if either most or at least one model each distinct species successfully applicable.

Language: Английский

Citations

0

Alcohol: Postmortem Findings - Acute and Chronic DOI
Alan Wayne Jones

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 165 - 194

Published: March 18, 2024

Language: Английский

Citations

0

Historical and Chemical Examination of Alcohol DOI
Cem Uysal

Published: Aug. 27, 2024

Patients with idiopathic pulmonary fibrosis contemplating pregnancy should receive comprehensive pre-pregnancy counseling, including discussions about the potential risks of on disease progression and maternal health. Collaborative care involving obstetricians, pulmonologists, maternal-fetal medicine specialists is essential to optimize fetal outcomes while minimizing both. Careful consideration be given medication selection dosing during pregnancy, a focus exposure teratogenic or harmful agents maintaining stability symptom control. Close monitoring lung function, symptoms, complications necessary throughout gestation, regular assessments detect any signs exacerbations. Elderly patients fibrosis. may present age-related changes in comorbidities, functional status, necessitating individualized management approaches. Comprehensive geriatric assessment, evaluation cognitive nutritional frailty, valuable identifying addressing vulnerabilities optimizing for elderly fibrosis.nTreatment decisions balance benefits pharmacological interventions, taking into account pharmacokinetic pharmacodynamic changes, polypharmacy, frailty.

Language: Английский

Citations

0

Gut fermentation syndrome as an alibi for a driver tested positive for alcohol: a case-based discussion DOI Creative Commons
Ewa Toruńska, Piotr Engelgardt, Maciej Krzyżanowski

et al.

Problems of Forensic Sciences, Journal Year: 2024, Volume and Issue: 139, P. 179 - 191

Published: Dec. 19, 2024

The intestinal fermentation syndrome (IFS) also known as the auto-brewery (ABS), is an extremely rare diagnosis. This involves endogenous production of alcohol by microorganisms in digestive system after consuming a high-carbohydrate meal. article describes case 65-year-old driver who was found to have 0.24 mg/l during sobriety test, which, according Polish law, defined state and considered misdemeanour. He explained his condition occurrence syndrome. After thorough analysis documentation submitted, it concluded that there no basis for assuming ethyl exhaled air resulted from accused’s health condition, medications taken him or meals consumed, presence discussed disease excluded. specificity encourages use diagnosis alibi detected body. Hence, such cases, important carefully conduct diagnostics, including differential diagnosis, microbiological tests and, above all, provocation test with glucose simultaneous monitoring level During possibility additional intake should be excluded avoid false results misdiagnosis.

Language: Английский

Citations

0