Extracellular Matrix Stiffness: Mechanotransduction and Mechanobiological Response-Driven Strategies for Biomedical Applications Targeting Fibroblast Inflammation
Polymers,
Journal Year:
2025,
Volume and Issue:
17(6), P. 822 - 822
Published: March 20, 2025
The
extracellular
matrix
(ECM)
is
a
dynamic
network
providing
mechanical
and
biochemical
cues
that
regulate
cellular
behavior.
ECM
stiffness
critically
influences
fibroblasts,
the
primary
producers,
particularly
in
inflammation
fibrosis.
This
review
explores
role
of
fibroblast-driven
tissue
remodeling,
focusing
on
physicochemical
biological
mechanisms
involved.
Engineered
materials,
hydrogels,
polydimethylsiloxane
(PDMS)
are
highlighted
for
replicating
tissue-specific
stiffness,
enabling
precise
control
over
cell–matrix
interactions.
surface
functionalization
substrate
including
collagen,
polydopamine,
fibronectin,
enhances
bioactivity
fibroblast
adhesion.
Key
mechanotransduction
pathways,
such
as
integrin
signaling
YAP/TAZ
activation,
related
to
regulating
behaviors
inflammatory
responses.
fibroblasts
driving
chronic
diseases
emphasizes
their
therapeutic
potentials.
Advances
ECM-modifying
strategies,
tunable
biomaterials
hydrogel-based
therapies,
explored
applications
engineering,
drug
delivery,
anti-inflammatory
treatments,
diagnostic
tools
accurate
diagnosis
prognosis
stiffness-related
diseases.
integrates
mechanobiology
with
biomedical
innovations,
comprehensive
responses
outlining
future
directions
targeted
therapies.
Language: Английский
Advancements in Wearable and Implantable BioMEMS Devices: Transforming Healthcare Through Technology
Micromachines,
Journal Year:
2025,
Volume and Issue:
16(5), P. 522 - 522
Published: April 28, 2025
Wearable
and
implantable
BioMEMSs
(biomedical
microelectromechanical
systems)
have
transformed
modern
healthcare
by
enabling
continuous,
personalized,
minimally
invasive
monitoring,
diagnostics,
therapy.
advanced
rapidly,
encompassing
a
diverse
range
of
biosensors,
bioelectronic
systems,
drug
delivery
platforms,
motion
tracking
technologies.
These
devices
enable
non-invasive,
real-time
monitoring
biochemical,
electrophysiological,
biomechanical
signals,
offering
personalized
proactive
solutions.
In
parallel,
BioMEMS
significantly
enhanced
long-term
targeted
delivery,
neurostimulation.
From
continuous
glucose
intraocular
pressure
to
programmable
bioelectric
implants
for
neuromodulation,
these
are
improving
precision
treatment
localized
This
review
explores
the
materials
technologies
driving
advancements
in
wearable
BioMEMSs,
focusing
on
their
impact
chronic
disease
management,
cardiology,
respiratory
care,
glaucoma
treatment.
We
also
highlight
integration
with
artificial
intelligence
(AI)
Internet
Things
(IoT),
paving
way
smarter,
data-driven
Despite
potential,
face
challenges
such
as
regulatory
complexities,
global
standardization,
societal
determinants.
Looking
ahead,
we
explore
emerging
directions
like
multifunctional
biodegradable
power
sources,
next-generation
point-of-care
diagnostics.
Collectively,
position
pivotal
enablers
future
patient-centric
systems.
Language: Английский