Evaluation of antiobesogenic properties of fermented foods: In silico insights
Journal of Food Science,
Journal Year:
2025,
Volume and Issue:
90(3)
Published: March 1, 2025
Obesity
prevalence
has
steadily
increased
over
the
past
decades.
Standard
approaches,
such
as
energy
expenditure,
lifestyle
changes,
a
balanced
diet,
and
use
of
specific
drugs,
are
conventional
strategies
for
preventing
or
treating
disease
its
associated
complications.
Fermented
foods
their
subsequent
bioactive
constituents
now
believed
to
be
novel
strategy
that
can
complement
already
existing
approaches
managing
this
disease.
Recent
developments
in
systems
biology
bioinformatics
have
made
it
possible
model
simulate
compounds
interactions.
The
adoption
silico
models
contributed
discovery
fermented
product
targets
helped
testing
hypotheses
regarding
mechanistic
impact
underlying
functions
food
components.
From
studies
explored,
key
findings
suggest
affect
adipogenesis,
lipid
metabolism,
appetite
regulation,
gut
microbiota
composition,
insulin
resistance,
inflammation
related
obesity,
which
could
lead
new
ways
treat
these
conditions.
These
outcomes
were
linked
probiotics,
prebiotics,
metabolites,
complex
substances
produced
during
fermentation.
Overall,
show
promise
innovative
tools
obesity
management
by
influencing
metabolic
pathways
overall
health.
Language: Английский
Effect of Sphingomyelin and Vitamin D3 Intake on the Rabbit Brain
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3269 - 3269
Published: April 1, 2025
Sphingomyelin
is
a
crucial
molecule
in
the
sphingolipid
metabolic
pathway,
and
its
action
closely
related
to
that
of
vitamin
D3.
Both
molecules
are
recognized
for
their
involvement
brain
pathophysiology.
In
this
study,
effect
sphingomyelin
+
D3-enriched
diet
was
investigated
rabbits.
The
results
showed
strong
immunopositive
GFAP
staining
brain's
white
matter.
Furthermore,
remodeling
balance
between
glycero-phospholipids
ether-phospholipids
observed
brain,
along
with
an
increase
ceramides
hexose
ceramides,
relevant
structure,
function,
stability
myelin.
Taken
together,
these
findings
provide
clues
as
how
combination
D3
may
play
vital
role
normal
physiology
could
potentially
be
leveraged
context
neurodegenerative
diseases.
Language: Английский
Supercritical CO2 Extraction of Natural Compounds from Capuchin (Tropaeolum majus) Leaves and Seeds
Processes,
Journal Year:
2024,
Volume and Issue:
12(8), P. 1566 - 1566
Published: July 26, 2024
This
study
investigated
the
supercritical
CO2
extraction
of
oils
from
capuchin
(Tropaeolum
majus)
seeds
(4.34%
moisture
content)
and
leaves
(5.26%
analyzed
effects
varying
temperature
pressure
conditions.
The
yields
were
3%
for
2%
leaves.
seed
extracts
rich
in
oleic,
linoleic,
palmitic
fatty
acids,
whereas
leaf
contained
a
high
concentration
octacosanol
(73.37%).
Kinetic
analysis
revealed
distinct
mass
transfer
mechanisms
during
extraction,
Sovová
model
effectively
described
kinetics,
showing
good
agreement
with
experimental
data
(ADD%
<
4%).
An
variance
(ANOVA)
demonstrated
impact
on
yields,
being
most
influential
factor.
conditions
ranged
22
to
28
MPa
313.15
333.15
K.
contributes
understanding
oil
its
potential
applications
various
fields,
owing
presence
bioactive
compounds.
Language: Английский