EGCG-Modified Bioactive Core–Shell Fibers Modulate Oxidative Stress to Synergistically Promote Vascularized Bone Regeneration
ACS Biomaterials Science & Engineering,
Journal Year:
2025,
Volume and Issue:
11(1), P. 543 - 555
Published: Jan. 2, 2025
Oxidative
stress
induced
by
reactive
oxygen
species
(ROS)
can
adversely
affect
tissue
repair,
whereas
endowing
biomaterials
with
antioxidant
activity
improve
the
in
vivo
microenvironment,
thereby
promoting
angiogenesis
and
osteogenesis.
Accordingly,
this
study
utilized
epigallocatechin-3-gallate
(EGCG),
a
material
known
for
its
reducing
properties,
oxidative
self-polymerization
capability,
strong
binding
characteristics,
to
modify
bioactive
core–shell
fibrous
membrane
(10RP-PG).
Compared
10RP-PG
membrane,
EGCG-modified
(E/10RP-PG)
exhibited
superior
hydrophilicity,
excellent
cell
adhesion,
compatibility.
Moreover,
effectively
scavenge
free
radicals,
ameliorate
local
foster
(enhancing
expression
of
angiogenic
genes
human
umbilical
vein
endothelial
cells
(HUVECs)
1.58
times
vascular
generation
area
upon
subcutaneous
implantation
4.47
times).
The
enhancement
E/10RP-PG
further
promoted
cartilage
degeneration
absorption,
as
well
new
bone
formation,
thus
facilitating
repair
defects.
This
provides
strategy
defect
through
surface
modification
an
agent,
fabricated
membranes
show
promise
guiding
vascularized
regeneration.
Language: Английский
Enhancement of antioxidant, carbonyl scavenging and anti-glycation activities of polysaccharide-based hydrocolloids by covalent grafting with gallic acid
International Journal of Biological Macromolecules,
Journal Year:
2025,
Volume and Issue:
307, P. 141855 - 141855
Published: March 7, 2025
Language: Английский
Capture of single or multiple reactive carbonyl species by mangiferin under high temperatures
Ruoying Du,
No information about this author
Liang Yu,
No information about this author
Si Bo
No information about this author
et al.
Food Chemistry,
Journal Year:
2024,
Volume and Issue:
460, P. 140712 - 140712
Published: July 30, 2024
Language: Английский
Widely Targeted Metabolomics Analysis of the Roots, Stems, Leaves, Flowers, and Fruits of Camellia luteoflora, a Species with an Extremely Small Population
Molecules,
Journal Year:
2024,
Volume and Issue:
29(19), P. 4754 - 4754
Published: Oct. 8, 2024
is
a
rare
and
endangered
plant
endemic
to
China.
It
has
high
ornamental
potential
economic
medicinal
value,
an
important
germplasm
resource
of
Camellia.
To
understand
the
distributions
differences
in
metabolites
from
different
parts
Language: Английский